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Slower Skeletal Muscle Oxygenation Kinetics in Adults With Complex Congenital Heart Disease

Sandberg, Camilla ; Crenshaw, Albert G. ; Elçadi, Guilherme H. ; Christersson, Christina ; Hlebowicz, Joanna LU ; Thilén, Ulf LU and Johansson, Bengt (2019) In Canadian Journal of Cardiology 35(12). p.1815-1823
Abstract

Background: Adults with complex congenital heart disease (CHD) show reduced aerobic exercise capacity and impaired skeletal muscle function compared with healthy peers. Peripheral muscle factors are presumed to be important contributors to the aerobic capacity, but the mechanisms are poorly understood. The aim of the present study was to investigate differences between adults with CHD and controls in muscle oxygenation kinetics at rest, and during and after exercise. Methods: Seventy-four patients with complex CHD (mean age 35.6 ± 14.3 years, female n = 22) were recruited. Seventy-four age- and sex-matched subjects were recruited as controls. Muscle oxygenation was successfully determined on the anterior portion of the deltoid muscle... (More)

Background: Adults with complex congenital heart disease (CHD) show reduced aerobic exercise capacity and impaired skeletal muscle function compared with healthy peers. Peripheral muscle factors are presumed to be important contributors to the aerobic capacity, but the mechanisms are poorly understood. The aim of the present study was to investigate differences between adults with CHD and controls in muscle oxygenation kinetics at rest, and during and after exercise. Methods: Seventy-four patients with complex CHD (mean age 35.6 ± 14.3 years, female n = 22) were recruited. Seventy-four age- and sex-matched subjects were recruited as controls. Muscle oxygenation was successfully determined on the anterior portion of the deltoid muscle using near-infrared spectroscopy in 65 patients and 71 controls. Measurements were made at rest, during isotonic shoulder flexions (0-90°) to exhaustion, and during recovery. Results: The patients with CHD performed fewer shoulder flexions (40 ± 17 vs 69 ± 40; P < 0.001), had lower muscle oxygen saturation (StO2) at rest (58 ± 18% vs 69 ± 18%; P < 0.001), slower desaturation rate at exercise onset (−9.7 ± 5.9 vs −15.1 ± 6.5% StO2 × 3.5 s−1, P <0.001), and slower resaturation rate post exercise (4.0 ± 2.7 vs 5.4 ± 3.6% StO2 × 3.5 s−1; P = 0.009) compared with the controls. Conclusions: In comparison with age- and sex-matched controls, adults with complex CHD had slower oxygenation kinetics. This altered skeletal muscle metabolism might contribute to the impaired skeletal muscle endurance capacity shown and thereby also to the reduced aerobic capacity in this population.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Canadian Journal of Cardiology
volume
35
issue
12
pages
1815 - 1823
publisher
Elsevier Inc.
external identifiers
  • pmid:31473068
  • scopus:85071303990
ISSN
0828-282X
DOI
10.1016/j.cjca.2019.05.001
language
English
LU publication?
yes
id
4aa5c166-a933-4391-8e13-37cff9801c57
date added to LUP
2019-09-12 11:55:08
date last changed
2020-07-08 05:03:38
@article{4aa5c166-a933-4391-8e13-37cff9801c57,
  abstract     = {<p>Background: Adults with complex congenital heart disease (CHD) show reduced aerobic exercise capacity and impaired skeletal muscle function compared with healthy peers. Peripheral muscle factors are presumed to be important contributors to the aerobic capacity, but the mechanisms are poorly understood. The aim of the present study was to investigate differences between adults with CHD and controls in muscle oxygenation kinetics at rest, and during and after exercise. Methods: Seventy-four patients with complex CHD (mean age 35.6 ± 14.3 years, female n = 22) were recruited. Seventy-four age- and sex-matched subjects were recruited as controls. Muscle oxygenation was successfully determined on the anterior portion of the deltoid muscle using near-infrared spectroscopy in 65 patients and 71 controls. Measurements were made at rest, during isotonic shoulder flexions (0-90°) to exhaustion, and during recovery. Results: The patients with CHD performed fewer shoulder flexions (40 ± 17 vs 69 ± 40; P &lt; 0.001), had lower muscle oxygen saturation (StO<sub>2</sub>) at rest (58 ± 18% vs 69 ± 18%; P &lt; 0.001), slower desaturation rate at exercise onset (−9.7 ± 5.9 vs −15.1 ± 6.5% StO<sub>2</sub> × 3.5 s<sup>−1</sup>, P &lt;0.001), and slower resaturation rate post exercise (4.0 ± 2.7 vs 5.4 ± 3.6% StO<sub>2</sub> × 3.5 s<sup>−1</sup>; P = 0.009) compared with the controls. Conclusions: In comparison with age- and sex-matched controls, adults with complex CHD had slower oxygenation kinetics. This altered skeletal muscle metabolism might contribute to the impaired skeletal muscle endurance capacity shown and thereby also to the reduced aerobic capacity in this population.</p>},
  author       = {Sandberg, Camilla and Crenshaw, Albert G. and Elçadi, Guilherme H. and Christersson, Christina and Hlebowicz, Joanna and Thilén, Ulf and Johansson, Bengt},
  issn         = {0828-282X},
  language     = {eng},
  number       = {12},
  pages        = {1815--1823},
  publisher    = {Elsevier Inc.},
  series       = {Canadian Journal of Cardiology},
  title        = {Slower Skeletal Muscle Oxygenation Kinetics in Adults With Complex Congenital Heart Disease},
  url          = {http://dx.doi.org/10.1016/j.cjca.2019.05.001},
  doi          = {10.1016/j.cjca.2019.05.001},
  volume       = {35},
  year         = {2019},
}