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Systemic inflammation and risk of multiple sclerosis – A presymptomatic case-control study

Grut, Viktor ; Biström, Martin ; Salzer, Jonatan ; Stridh, Pernilla ; Lindam, Anna ; Alonso-Magdalena, Lucia LU ; Andersen, Oluf ; Jons, Daniel ; Gunnarsson, Martin and Vrethem, Magnus , et al. (2022) In Multiple Sclerosis Journal - Experimental, Translational and Clinical 8(4).
Abstract

Background: C-reactive protein (CRP) is a marker of systemic inflammation. Increased levels of CRP in young persons have been suggested to decrease the risk of multiple sclerosis (MS). Objectives: To assess CRP as a risk factor for MS. Methods: Levels of CRP were measured with a high-sensitive immunoassay in biobank samples from 837 individuals who later developed MS and 984 matched controls. The risk of developing MS was analysed by conditional logistic regression on z-scored CRP values. Results: Levels of CRP were not associated with MS risk. Conclusions: We found no association between CRP levels and risk of MS development.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
C-reactive protein, Case-control studies, multiple sclerosis, systemic inflammation
in
Multiple Sclerosis Journal - Experimental, Translational and Clinical
volume
8
issue
4
publisher
SAGE Publications
external identifiers
  • scopus:85142702455
  • pmid:36440320
ISSN
2055-2173
DOI
10.1177/20552173221139768
language
English
LU publication?
yes
id
4adfdb52-f192-4a3b-8539-96cdf2cfaaab
date added to LUP
2022-12-29 11:20:33
date last changed
2024-04-18 17:22:48
@article{4adfdb52-f192-4a3b-8539-96cdf2cfaaab,
  abstract     = {{<p>Background: C-reactive protein (CRP) is a marker of systemic inflammation. Increased levels of CRP in young persons have been suggested to decrease the risk of multiple sclerosis (MS). Objectives: To assess CRP as a risk factor for MS. Methods: Levels of CRP were measured with a high-sensitive immunoassay in biobank samples from 837 individuals who later developed MS and 984 matched controls. The risk of developing MS was analysed by conditional logistic regression on z-scored CRP values. Results: Levels of CRP were not associated with MS risk. Conclusions: We found no association between CRP levels and risk of MS development.</p>}},
  author       = {{Grut, Viktor and Biström, Martin and Salzer, Jonatan and Stridh, Pernilla and Lindam, Anna and Alonso-Magdalena, Lucia and Andersen, Oluf and Jons, Daniel and Gunnarsson, Martin and Vrethem, Magnus and Hultdin, Johan and Sundström, Peter}},
  issn         = {{2055-2173}},
  keywords     = {{C-reactive protein; Case-control studies; multiple sclerosis; systemic inflammation}},
  language     = {{eng}},
  month        = {{10}},
  number       = {{4}},
  publisher    = {{SAGE Publications}},
  series       = {{Multiple Sclerosis Journal - Experimental, Translational and Clinical}},
  title        = {{Systemic inflammation and risk of multiple sclerosis – A presymptomatic case-control study}},
  url          = {{http://dx.doi.org/10.1177/20552173221139768}},
  doi          = {{10.1177/20552173221139768}},
  volume       = {{8}},
  year         = {{2022}},
}