Systemic inflammation and risk of multiple sclerosis – A presymptomatic case-control study
(2022) In Multiple Sclerosis Journal - Experimental, Translational and Clinical 8(4).- Abstract
Background: C-reactive protein (CRP) is a marker of systemic inflammation. Increased levels of CRP in young persons have been suggested to decrease the risk of multiple sclerosis (MS). Objectives: To assess CRP as a risk factor for MS. Methods: Levels of CRP were measured with a high-sensitive immunoassay in biobank samples from 837 individuals who later developed MS and 984 matched controls. The risk of developing MS was analysed by conditional logistic regression on z-scored CRP values. Results: Levels of CRP were not associated with MS risk. Conclusions: We found no association between CRP levels and risk of MS development.
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https://lup.lub.lu.se/record/4adfdb52-f192-4a3b-8539-96cdf2cfaaab
- author
- organization
- publishing date
- 2022-10-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- C-reactive protein, Case-control studies, multiple sclerosis, systemic inflammation
- in
- Multiple Sclerosis Journal - Experimental, Translational and Clinical
- volume
- 8
- issue
- 4
- publisher
- SAGE Publications
- external identifiers
-
- scopus:85142702455
- pmid:36440320
- ISSN
- 2055-2173
- DOI
- 10.1177/20552173221139768
- language
- English
- LU publication?
- yes
- id
- 4adfdb52-f192-4a3b-8539-96cdf2cfaaab
- date added to LUP
- 2022-12-29 11:20:33
- date last changed
- 2024-04-18 17:22:48
@article{4adfdb52-f192-4a3b-8539-96cdf2cfaaab, abstract = {{<p>Background: C-reactive protein (CRP) is a marker of systemic inflammation. Increased levels of CRP in young persons have been suggested to decrease the risk of multiple sclerosis (MS). Objectives: To assess CRP as a risk factor for MS. Methods: Levels of CRP were measured with a high-sensitive immunoassay in biobank samples from 837 individuals who later developed MS and 984 matched controls. The risk of developing MS was analysed by conditional logistic regression on z-scored CRP values. Results: Levels of CRP were not associated with MS risk. Conclusions: We found no association between CRP levels and risk of MS development.</p>}}, author = {{Grut, Viktor and Biström, Martin and Salzer, Jonatan and Stridh, Pernilla and Lindam, Anna and Alonso-Magdalena, Lucia and Andersen, Oluf and Jons, Daniel and Gunnarsson, Martin and Vrethem, Magnus and Hultdin, Johan and Sundström, Peter}}, issn = {{2055-2173}}, keywords = {{C-reactive protein; Case-control studies; multiple sclerosis; systemic inflammation}}, language = {{eng}}, month = {{10}}, number = {{4}}, publisher = {{SAGE Publications}}, series = {{Multiple Sclerosis Journal - Experimental, Translational and Clinical}}, title = {{Systemic inflammation and risk of multiple sclerosis – A presymptomatic case-control study}}, url = {{http://dx.doi.org/10.1177/20552173221139768}}, doi = {{10.1177/20552173221139768}}, volume = {{8}}, year = {{2022}}, }