Feasibility of noninvasive transthoracic echocardiography/Doppler measurement of coronary flow reserve in left anterior descending coronary artery in patients with acute coronary syndrome: A new technique tested in clinical practice
(2003) In Journal of the American Society of Echocardiography 16(5). p.464-468- Abstract
- Objective: The aim of this study was to test the feasibility and accuracy of transthoracic Doppler echocardiography measurement of coronary flow reserve (CFR) in the left anterior descending coronary artery (LAD) territory in the clinical setting of the acute coronary syndrome. Methods: Transthoracic Doppler echocardiography measurements of CFR were made in 42 consecutive patients in the distal LAD before and during adenosine infusion. The results were validated by coronary angiography. A normal CFR was predefined as a more than 2-fold increase of flow velocity during adenosine infusion. Results. We were able to detect significant stenosis in the LAD territory with 92% sensitivity and 82% specificity if we considered a stenosis greater... (More)
- Objective: The aim of this study was to test the feasibility and accuracy of transthoracic Doppler echocardiography measurement of coronary flow reserve (CFR) in the left anterior descending coronary artery (LAD) territory in the clinical setting of the acute coronary syndrome. Methods: Transthoracic Doppler echocardiography measurements of CFR were made in 42 consecutive patients in the distal LAD before and during adenosine infusion. The results were validated by coronary angiography. A normal CFR was predefined as a more than 2-fold increase of flow velocity during adenosine infusion. Results. We were able to detect significant stenosis in the LAD territory with 92% sensitivity and 82% specificity if we considered a stenosis greater than or equal to 50% to be significant. Defining a stenosis of greater than or equal to 70% as significant increased the sensitivity and the negative-predictive value to 100%, with a specificity of 70%. Conclusion: Measuring CFR using transthoracic Doppler echocardiography is noninvasive, feasible, accurate, and relatively inexpensive. The excellent negative-predictive value of this technique makes it a useful tool for identifying patients who can avoid repeated angiography as a result of suspected subacute LAD restenosis after percutaneous coronary intervention. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/310851
- author
- Winter, Reidar LU ; Gudmundsson, P and Willenheimer, Ronnie LU
- organization
- publishing date
- 2003
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of the American Society of Echocardiography
- volume
- 16
- issue
- 5
- pages
- 464 - 468
- publisher
- Elsevier
- external identifiers
-
- wos:000182804900011
- pmid:12724656
- scopus:0038558149
- ISSN
- 1097-6795
- DOI
- 10.1016/S0894-7317(03)00112-3
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Cardiology Research Group (013242120), Emergency medicine/Medicine/Surgery (013240200)
- id
- 4ae6e37f-020a-4f40-82c1-3c39634e754f (old id 310851)
- date added to LUP
- 2016-04-01 16:20:44
- date last changed
- 2022-01-28 19:01:24
@article{4ae6e37f-020a-4f40-82c1-3c39634e754f, abstract = {{Objective: The aim of this study was to test the feasibility and accuracy of transthoracic Doppler echocardiography measurement of coronary flow reserve (CFR) in the left anterior descending coronary artery (LAD) territory in the clinical setting of the acute coronary syndrome. Methods: Transthoracic Doppler echocardiography measurements of CFR were made in 42 consecutive patients in the distal LAD before and during adenosine infusion. The results were validated by coronary angiography. A normal CFR was predefined as a more than 2-fold increase of flow velocity during adenosine infusion. Results. We were able to detect significant stenosis in the LAD territory with 92% sensitivity and 82% specificity if we considered a stenosis greater than or equal to 50% to be significant. Defining a stenosis of greater than or equal to 70% as significant increased the sensitivity and the negative-predictive value to 100%, with a specificity of 70%. Conclusion: Measuring CFR using transthoracic Doppler echocardiography is noninvasive, feasible, accurate, and relatively inexpensive. The excellent negative-predictive value of this technique makes it a useful tool for identifying patients who can avoid repeated angiography as a result of suspected subacute LAD restenosis after percutaneous coronary intervention.}}, author = {{Winter, Reidar and Gudmundsson, P and Willenheimer, Ronnie}}, issn = {{1097-6795}}, language = {{eng}}, number = {{5}}, pages = {{464--468}}, publisher = {{Elsevier}}, series = {{Journal of the American Society of Echocardiography}}, title = {{Feasibility of noninvasive transthoracic echocardiography/Doppler measurement of coronary flow reserve in left anterior descending coronary artery in patients with acute coronary syndrome: A new technique tested in clinical practice}}, url = {{http://dx.doi.org/10.1016/S0894-7317(03)00112-3}}, doi = {{10.1016/S0894-7317(03)00112-3}}, volume = {{16}}, year = {{2003}}, }