Influence of early-life parental severe life events on the risk of type 1 diabetes in children : the DiPiS study
(2018) In Acta Diabetologica 55(8). p.797-804- Abstract
Aims: Stress and severe life events (SLEs) modify autoimmune disease susceptibility. Here, we aimed to establish if SLEs reported by parents during the first 2 years of life influence the risk of developing type 1 diabetes (T1D) using data from the prospective Diabetes Prediction in Skåne (DiPiS) study. Methods: Prospective questionnaire data recorded at 2 months (n = 23,187) and 2 years of age (n = 3784) from the DiPiS cohort of children were included in the analysis. SLEs were analyzed both by groups and as a combined variable. A Cox proportional hazards model was used to calculate hazard ratios (HRs) for T1D diagnosis for the total cohort and for the HLA-DQ2/8 high-risk population. Affected first-degree relatives, HLA-DQ risk group,... (More)
Aims: Stress and severe life events (SLEs) modify autoimmune disease susceptibility. Here, we aimed to establish if SLEs reported by parents during the first 2 years of life influence the risk of developing type 1 diabetes (T1D) using data from the prospective Diabetes Prediction in Skåne (DiPiS) study. Methods: Prospective questionnaire data recorded at 2 months (n = 23,187) and 2 years of age (n = 3784) from the DiPiS cohort of children were included in the analysis. SLEs were analyzed both by groups and as a combined variable. A Cox proportional hazards model was used to calculate hazard ratios (HRs) for T1D diagnosis for the total cohort and for the HLA-DQ2/8 high-risk population. Affected first-degree relatives, HLA-DQ risk group, paternal education level, and parents’ country of birth were included as covariates. Results: There was a significantly increased risk of T1D in children with SLEs occurring during the child’s first 2 years of life for both the total cohort (HR 1.67; 95% CI 1.1, 2.7; p = 0.03) and the DQ2/8 cohort (HR 2.2; 95% CI 1.1, 4.2; p = 0.018). Subgroup analysis of events related to unemployment, divorce, or family conflict showed a significant hazard for these events occurring both during and after pregnancy in the DQ2/8 cohort (HR 2.17; 95% CI 1.1, 4.3; p = 0.03 and HR 4.98; 95% CI 2.3, 11; p < 0.001, respectively) and after pregnancy in the total cohort (multiple regression HR 2.07; 95% CI 1.01, 4.2; p = 0.047). Conclusions: Children of parents experiencing an SLE during the child’s first 2 years of life were at increased risk of T1D. Further studies including those measuring immune and stress-related biomarkers are necessary to validate the findings.
(Less)
- author
- Lundgren, Markus LU ; Ellström, Katarina LU and Elding Larsson, Helena LU
- organization
- publishing date
- 2018-05-12
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Diabetes mellitus, Pediatrics, Prospective studies, Psychological, Stress, Type 1
- in
- Acta Diabetologica
- volume
- 55
- issue
- 8
- pages
- 797 - 804
- publisher
- Springer
- external identifiers
-
- pmid:29752553
- scopus:85046821987
- ISSN
- 0940-5429
- DOI
- 10.1007/s00592-018-1150-y
- language
- English
- LU publication?
- yes
- id
- 4afb2d1a-98b3-42a1-b2b3-d76352c61b65
- date added to LUP
- 2018-05-23 13:57:04
- date last changed
- 2024-09-02 20:46:20
@article{4afb2d1a-98b3-42a1-b2b3-d76352c61b65, abstract = {{<p>Aims: Stress and severe life events (SLEs) modify autoimmune disease susceptibility. Here, we aimed to establish if SLEs reported by parents during the first 2 years of life influence the risk of developing type 1 diabetes (T1D) using data from the prospective Diabetes Prediction in Skåne (DiPiS) study. Methods: Prospective questionnaire data recorded at 2 months (n = 23,187) and 2 years of age (n = 3784) from the DiPiS cohort of children were included in the analysis. SLEs were analyzed both by groups and as a combined variable. A Cox proportional hazards model was used to calculate hazard ratios (HRs) for T1D diagnosis for the total cohort and for the HLA-DQ2/8 high-risk population. Affected first-degree relatives, HLA-DQ risk group, paternal education level, and parents’ country of birth were included as covariates. Results: There was a significantly increased risk of T1D in children with SLEs occurring during the child’s first 2 years of life for both the total cohort (HR 1.67; 95% CI 1.1, 2.7; p = 0.03) and the DQ2/8 cohort (HR 2.2; 95% CI 1.1, 4.2; p = 0.018). Subgroup analysis of events related to unemployment, divorce, or family conflict showed a significant hazard for these events occurring both during and after pregnancy in the DQ2/8 cohort (HR 2.17; 95% CI 1.1, 4.3; p = 0.03 and HR 4.98; 95% CI 2.3, 11; p < 0.001, respectively) and after pregnancy in the total cohort (multiple regression HR 2.07; 95% CI 1.01, 4.2; p = 0.047). Conclusions: Children of parents experiencing an SLE during the child’s first 2 years of life were at increased risk of T1D. Further studies including those measuring immune and stress-related biomarkers are necessary to validate the findings.</p>}}, author = {{Lundgren, Markus and Ellström, Katarina and Elding Larsson, Helena}}, issn = {{0940-5429}}, keywords = {{Diabetes mellitus; Pediatrics; Prospective studies; Psychological; Stress; Type 1}}, language = {{eng}}, month = {{05}}, number = {{8}}, pages = {{797--804}}, publisher = {{Springer}}, series = {{Acta Diabetologica}}, title = {{Influence of early-life parental severe life events on the risk of type 1 diabetes in children : the DiPiS study}}, url = {{http://dx.doi.org/10.1007/s00592-018-1150-y}}, doi = {{10.1007/s00592-018-1150-y}}, volume = {{55}}, year = {{2018}}, }