Genetic differences between suicide deaths and deaths of undetermined intent
(2023) In Suicide and Life-Threatening Behavior 53(1). p.100-109- Abstract
Introduction: Few, if any, prior studies have considered whether undetermined intent (UDI) deaths and suicide deaths differ with respect to genetic liability for suicidal behavior or psychopathology. Methods: The authors used Swedish national registry data to identify suicide deaths (N = 31,835) and UDI deaths (N = 10,623); sociodemographic covariates; and registrations for psychopathology. Family genetic risk scores (FGRS) were derived for each form of psychopathology. The authors used LASSO models to assess genetic and phenotypic differences across outcomes. Results: In the multivariate LASSO regressions, higher FGRS for major depression, bipolar disorder, and suicide death were associated with lower odds of UDI relative to... (More)
Introduction: Few, if any, prior studies have considered whether undetermined intent (UDI) deaths and suicide deaths differ with respect to genetic liability for suicidal behavior or psychopathology. Methods: The authors used Swedish national registry data to identify suicide deaths (N = 31,835) and UDI deaths (N = 10,623); sociodemographic covariates; and registrations for psychopathology. Family genetic risk scores (FGRS) were derived for each form of psychopathology. The authors used LASSO models to assess genetic and phenotypic differences across outcomes. Results: In the multivariate LASSO regressions, higher FGRS for major depression, bipolar disorder, and suicide death were associated with lower odds of UDI relative to unambiguous suicide (OR = 0.91–0.95), while those for alcohol and drug use disorders, ADHD, and criminal behavior were associated with higher odds of UDI relative to unambiguous suicide (OR = 1.04–1.12). When the corresponding phenotypic registration status for these outcomes was included in a subsequent model, the associations were attenuated and of small magnitude, but many remained different from OR = 1. Conclusions: Aggregate genetic differences between unambiguous suicide decedents and UDI deaths are small, particularly when accounting for psychiatric comorbidity, but in some cases, statistically significant. These findings suggest that different analytic treatment of UDI deaths may be warranted depending on the research question. Replication in other samples, and using molecular genetic data, is necessary.
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- author
- Edwards, Alexis C. LU ; Ohlsson, Henrik LU ; Mościcki, Eve K. ; Sundquist, Jan LU ; Crump, Casey LU ; Kendler, Kenneth S. and Sundquist, Kristina LU
- organization
- publishing date
- 2023
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- aggregate genetics, psychiatric comorbidity, suicide, undetermined intent death
- in
- Suicide and Life-Threatening Behavior
- volume
- 53
- issue
- 1
- pages
- 100 - 109
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- scopus:85141424212
- pmid:36314433
- ISSN
- 0363-0234
- DOI
- 10.1111/sltb.12926
- language
- English
- LU publication?
- yes
- id
- 4b71c3db-40ca-4d4d-b1fc-0f47a36937ae
- date added to LUP
- 2022-12-20 16:34:55
- date last changed
- 2024-06-13 23:59:49
@article{4b71c3db-40ca-4d4d-b1fc-0f47a36937ae,
abstract = {{<p>Introduction: Few, if any, prior studies have considered whether undetermined intent (UDI) deaths and suicide deaths differ with respect to genetic liability for suicidal behavior or psychopathology. Methods: The authors used Swedish national registry data to identify suicide deaths (N = 31,835) and UDI deaths (N = 10,623); sociodemographic covariates; and registrations for psychopathology. Family genetic risk scores (FGRS) were derived for each form of psychopathology. The authors used LASSO models to assess genetic and phenotypic differences across outcomes. Results: In the multivariate LASSO regressions, higher FGRS for major depression, bipolar disorder, and suicide death were associated with lower odds of UDI relative to unambiguous suicide (OR = 0.91–0.95), while those for alcohol and drug use disorders, ADHD, and criminal behavior were associated with higher odds of UDI relative to unambiguous suicide (OR = 1.04–1.12). When the corresponding phenotypic registration status for these outcomes was included in a subsequent model, the associations were attenuated and of small magnitude, but many remained different from OR = 1. Conclusions: Aggregate genetic differences between unambiguous suicide decedents and UDI deaths are small, particularly when accounting for psychiatric comorbidity, but in some cases, statistically significant. These findings suggest that different analytic treatment of UDI deaths may be warranted depending on the research question. Replication in other samples, and using molecular genetic data, is necessary.</p>}},
author = {{Edwards, Alexis C. and Ohlsson, Henrik and Mościcki, Eve K. and Sundquist, Jan and Crump, Casey and Kendler, Kenneth S. and Sundquist, Kristina}},
issn = {{0363-0234}},
keywords = {{aggregate genetics; psychiatric comorbidity; suicide; undetermined intent death}},
language = {{eng}},
number = {{1}},
pages = {{100--109}},
publisher = {{John Wiley & Sons Inc.}},
series = {{Suicide and Life-Threatening Behavior}},
title = {{Genetic differences between suicide deaths and deaths of undetermined intent}},
url = {{http://dx.doi.org/10.1111/sltb.12926}},
doi = {{10.1111/sltb.12926}},
volume = {{53}},
year = {{2023}},
}