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Human pulmonary 3D models for translational research

Zscheppang, Katja; Berg, Johanna; Hedtrich, Sarah; Verheyen, Leonie; Wagner, Darcy E LU ; Suttorp, Norbert; Hippenstiel, Stefan and Hocke, Andreas C (2017) In Biotechnology Journal
Abstract

Lung diseases belong the major causes of death worldwide. Recent innovative methodological developments now allow more and more for the use of primary human tissue and cells to model such diseases. In this regard, the review covers bronchial air-liquid interface cultures, precision cut lung slices as well as ex vivo cultures of explanted peripheral lung tissue and de-/re-cellularization models. Diseases such as asthma or infections are discussed and an outlook on further areas for development is given. Overall, the progress in ex vivo modelling by using primary human material could make translational research activities more efficient by simultaneously fostering the mechanistic understanding of human lung diseases while reducing animal... (More)

Lung diseases belong the major causes of death worldwide. Recent innovative methodological developments now allow more and more for the use of primary human tissue and cells to model such diseases. In this regard, the review covers bronchial air-liquid interface cultures, precision cut lung slices as well as ex vivo cultures of explanted peripheral lung tissue and de-/re-cellularization models. Diseases such as asthma or infections are discussed and an outlook on further areas for development is given. Overall, the progress in ex vivo modelling by using primary human material could make translational research activities more efficient by simultaneously fostering the mechanistic understanding of human lung diseases while reducing animal usage in biomedical research.

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Please use this url to cite or link to this publication:
author
publishing date
type
Contribution to journal
publication status
epub
keywords
Journal Article, Review
in
Biotechnology Journal
publisher
John Wiley & Sons
external identifiers
  • scopus:85030025941
ISSN
1860-6768
DOI
10.1002/biot.201700341
language
English
LU publication?
no
id
4b82fc08-1103-40ae-acca-2179c2582780
date added to LUP
2017-09-18 15:20:27
date last changed
2018-01-07 12:18:58
@article{4b82fc08-1103-40ae-acca-2179c2582780,
  abstract     = {<p>Lung diseases belong the major causes of death worldwide. Recent innovative methodological developments now allow more and more for the use of primary human tissue and cells to model such diseases. In this regard, the review covers bronchial air-liquid interface cultures, precision cut lung slices as well as ex vivo cultures of explanted peripheral lung tissue and de-/re-cellularization models. Diseases such as asthma or infections are discussed and an outlook on further areas for development is given. Overall, the progress in ex vivo modelling by using primary human material could make translational research activities more efficient by simultaneously fostering the mechanistic understanding of human lung diseases while reducing animal usage in biomedical research.</p>},
  author       = {Zscheppang, Katja and Berg, Johanna and Hedtrich, Sarah and Verheyen, Leonie and Wagner, Darcy E and Suttorp, Norbert and Hippenstiel, Stefan and Hocke, Andreas C},
  issn         = {1860-6768},
  keyword      = {Journal Article,Review},
  language     = {eng},
  month        = {09},
  publisher    = {John Wiley & Sons},
  series       = {Biotechnology Journal},
  title        = {Human pulmonary 3D models for translational research},
  url          = {http://dx.doi.org/10.1002/biot.201700341},
  year         = {2017},
}