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Plasma Biomarkers for Clinical Assessment of Bone Mineral Density in Heart Transplanted Patients—A Single-Center Study at Skåne University Hospital in Lund

Löfdahl, Eveline LU ; Ahmed, Salaheldin LU orcid ; Ahmed, Abdulla LU orcid and Rådegran, Göran LU (2022) In Transplant International 35.
Abstract

We aimed to identify plasma biomarkers that predict changes in bone mineral density (BMD) and increase the understanding of impaired BMD after heart transplantation (HT). Twenty-eight adult patients were included. Data, including densitometry and 29 plasma proteins, before and 1 year after HT were analyzed. Pre-HT plasma levels of fibroblast growth factor 23 (FGF23) correlated with post-HT T score in lumbar spine, adjusted for age, gender, and BMI (1.72 [95% CI 1.33; 2.22], p = 0.011). Change (∆; post-HT—pre-HT) in plasma levels of melusin correlated to ∆T score from the lumbar spine (p = 0.028). ∆plasma levels of TR-AP, ITGB2, and Stromelysin-1 correlated to ∆T score from the femoral neck (p < 0.05). However, no correlations... (More)

We aimed to identify plasma biomarkers that predict changes in bone mineral density (BMD) and increase the understanding of impaired BMD after heart transplantation (HT). Twenty-eight adult patients were included. Data, including densitometry and 29 plasma proteins, before and 1 year after HT were analyzed. Pre-HT plasma levels of fibroblast growth factor 23 (FGF23) correlated with post-HT T score in lumbar spine, adjusted for age, gender, and BMI (1.72 [95% CI 1.33; 2.22], p = 0.011). Change (∆; post-HT—pre-HT) in plasma levels of melusin correlated to ∆T score from the lumbar spine (p = 0.028). ∆plasma levels of TR-AP, ITGB2, and Stromelysin-1 correlated to ∆T score from the femoral neck (p < 0.05). However, no correlations remained after adjustments for age, gender, and BMI. In conclusion, elevated plasma FGF23 pre-HT predicted an increase in lumbar BMD after HT. However, the results are surprising since FGF23 is known to be inversely correlated with BMD. This may partly be explained by the complex pathophysiology in this particular cohort. Due to the explorative nature of the study and the small sample size, further investigations of biochemical markers on bone metabolism in this patient population are encouraged.

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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
bone metabolism, bone mineral density, heart transplantation, osteoporosis, plasma biomarkers
in
Transplant International
volume
35
article number
10161
publisher
Springer
external identifiers
  • scopus:85128430222
  • pmid:36148003
ISSN
0934-0874
DOI
10.3389/ti.2022.10161
language
English
LU publication?
yes
id
4be50b4f-0394-479a-ad80-4edd7b9c5e6b
date added to LUP
2022-07-01 15:00:21
date last changed
2024-05-30 17:02:05
@article{4be50b4f-0394-479a-ad80-4edd7b9c5e6b,
  abstract     = {{<p>We aimed to identify plasma biomarkers that predict changes in bone mineral density (BMD) and increase the understanding of impaired BMD after heart transplantation (HT). Twenty-eight adult patients were included. Data, including densitometry and 29 plasma proteins, before and 1 year after HT were analyzed. Pre-HT plasma levels of fibroblast growth factor 23 (FGF23) correlated with post-HT T score in lumbar spine, adjusted for age, gender, and BMI (1.72 [95% CI 1.33; 2.22], p = 0.011). Change (∆; post-HT—pre-HT) in plasma levels of melusin correlated to ∆T score from the lumbar spine (p = 0.028). ∆plasma levels of TR-AP, ITGB2, and Stromelysin-1 correlated to ∆T score from the femoral neck (p &lt; 0.05). However, no correlations remained after adjustments for age, gender, and BMI. In conclusion, elevated plasma FGF23 pre-HT predicted an increase in lumbar BMD after HT. However, the results are surprising since FGF23 is known to be inversely correlated with BMD. This may partly be explained by the complex pathophysiology in this particular cohort. Due to the explorative nature of the study and the small sample size, further investigations of biochemical markers on bone metabolism in this patient population are encouraged.</p>}},
  author       = {{Löfdahl, Eveline and Ahmed, Salaheldin and Ahmed, Abdulla and Rådegran, Göran}},
  issn         = {{0934-0874}},
  keywords     = {{bone metabolism; bone mineral density; heart transplantation; osteoporosis; plasma biomarkers}},
  language     = {{eng}},
  month        = {{03}},
  publisher    = {{Springer}},
  series       = {{Transplant International}},
  title        = {{Plasma Biomarkers for Clinical Assessment of Bone Mineral Density in Heart Transplanted Patients—A Single-Center Study at Skåne University Hospital in Lund}},
  url          = {{http://dx.doi.org/10.3389/ti.2022.10161}},
  doi          = {{10.3389/ti.2022.10161}},
  volume       = {{35}},
  year         = {{2022}},
}