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Hyperplasia and hypertrophia in the denervated and distended rat urinary bladder

Ekström, J ; Henningsson, Anne-Charlotte LU ; Henningsson, S and Malmberg, Lars LU (1984) In Acta Physiologica Scandinavica 122(1). p.45-48
Abstract
The parasympathetically denervated and distended rat urinary bladder was found to have increased fourfold in weight when examined 3 weeks postoperatively. Both in muscularis and mucosa of such a bladder the synthesis of proteins, RNA and DNA was increased severalfold. An increase in the polyamines putrescine, spermidine and spermine was also found; these polyamines are usually linked to protein synthesis. The results suggest that the cells of the two layers increase both in size and number. Hyperplasia was, in a previous study, suggested as a possible explanation for a right-ward shift of the active length-tension curve of muscle strips in the denervated rat urinary bladder.
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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta Physiologica Scandinavica
volume
122
issue
1
pages
45 - 48
publisher
Wiley-Blackwell
external identifiers
  • pmid:6209921
  • scopus:0021131448
ISSN
0001-6772
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Department of Urology, Lund (013077000), Pediatrics/Urology/Gynecology/Endocrinology (013240400)
id
4bed0513-672b-430a-853d-2030bd07a8dd (old id 1103269)
date added to LUP
2016-04-01 16:17:32
date last changed
2021-08-29 04:35:51
@article{4bed0513-672b-430a-853d-2030bd07a8dd,
  abstract     = {{The parasympathetically denervated and distended rat urinary bladder was found to have increased fourfold in weight when examined 3 weeks postoperatively. Both in muscularis and mucosa of such a bladder the synthesis of proteins, RNA and DNA was increased severalfold. An increase in the polyamines putrescine, spermidine and spermine was also found; these polyamines are usually linked to protein synthesis. The results suggest that the cells of the two layers increase both in size and number. Hyperplasia was, in a previous study, suggested as a possible explanation for a right-ward shift of the active length-tension curve of muscle strips in the denervated rat urinary bladder.}},
  author       = {{Ekström, J and Henningsson, Anne-Charlotte and Henningsson, S and Malmberg, Lars}},
  issn         = {{0001-6772}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{45--48}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Acta Physiologica Scandinavica}},
  title        = {{Hyperplasia and hypertrophia in the denervated and distended rat urinary bladder}},
  volume       = {{122}},
  year         = {{1984}},
}