Detection of Non-Small Lung Cell Carcinoma-Associated Genetic Alterations Using a NanoString Gene Expression Platform Approach
Staaf, Johan LU
; Jönsson, Mats
LU
and Karlsson, Anna F.
LU
(2021)
In Methods in Molecular Biology
2279.
p.91-107
- Abstract
In non-small cell lung cancer (NSCLC), mutation detection and fusion gene status are treatment predictive and, hence, key factors in clinical management. Lately, alternate splicing variants of MET have gained focus as NSCLC tumors harboring a MET exon 14 skipping event have proven sensitive toward targeted therapy. Reliable methods for detection of genetic alterations in NSCLC have proven to be of increased importance. This chapter provides with hands-on experience of the NanoString gene expression platform for detection of genetic alterations in NSCLC.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4c37c63a-db85-4349-a3cf-84db001d48f0
- author
- Staaf, Johan
LU
; Jönsson, Mats
LU
and Karlsson, Anna F.
LU
- organization
- publishing date
- 2021
- type
- Chapter in Book/Report/Conference proceeding
- publication status
- published
- subject
- keywords
- Fusion gene, Gene expression, NanoString, Non-small cell lung carcinoma
- host publication
- Lung Cancer : Methods and Protocols - Methods and Protocols
- series title
- Methods in Molecular Biology
- editor
- Santiago-Cardona, Pedro G.
- volume
- 2279
- pages
- 17 pages
- publisher
- Humana Press
- external identifiers
-
- pmid:33683688
- scopus:85102521608
- ISSN
- 1064-3745
- 1940-6029
- ISBN
- 978-1-0716-1280-4
- 978-1-0716-1278-1
- DOI
- 10.1007/978-1-0716-1278-1_8
- language
- English
- LU publication?
- yes
- id
- 4c37c63a-db85-4349-a3cf-84db001d48f0
- alternative location
- https://link.springer.com/protocol/10.1007/978-1-0716-1278-1_8
- date added to LUP
- 2021-03-29 07:33:08
- date last changed
- 2024-03-23 02:06:03
@inbook{4c37c63a-db85-4349-a3cf-84db001d48f0,
abstract = {{<p>In non-small cell lung cancer (NSCLC), mutation detection and fusion gene status are treatment predictive and, hence, key factors in clinical management. Lately, alternate splicing variants of MET have gained focus as NSCLC tumors harboring a MET exon 14 skipping event have proven sensitive toward targeted therapy. Reliable methods for detection of genetic alterations in NSCLC have proven to be of increased importance. This chapter provides with hands-on experience of the NanoString gene expression platform for detection of genetic alterations in NSCLC.</p>}},
author = {{Staaf, Johan and Jönsson, Mats and Karlsson, Anna F.}},
booktitle = {{Lung Cancer : Methods and Protocols}},
editor = {{Santiago-Cardona, Pedro G.}},
isbn = {{978-1-0716-1280-4}},
issn = {{1064-3745}},
keywords = {{Fusion gene; Gene expression; NanoString; Non-small cell lung carcinoma}},
language = {{eng}},
pages = {{91--107}},
publisher = {{Humana Press}},
series = {{Methods in Molecular Biology}},
title = {{Detection of Non-Small Lung Cell Carcinoma-Associated Genetic Alterations Using a NanoString Gene Expression Platform Approach}},
url = {{http://dx.doi.org/10.1007/978-1-0716-1278-1_8}},
doi = {{10.1007/978-1-0716-1278-1_8}},
volume = {{2279}},
year = {{2021}},
}