CSF levels of synaptosomal-associated protein 25 and synaptotagmin-1 in first-episode psychosis subjects
(2020) In IBRO Reports 8. p.136-142- Abstract
Post-mortem studies consistently show evidence of reduced synaptic protein levels in patients with schizophrenia. Clinically high-risk subjects show a steeper decrease in grey matter thickness and in vitro modeling using patient-derived cells implicate excessive synaptic pruning during neurodevelopment as a part of the schizophrenia pathophysiology. However, it is unclear to what extent synapse elimination is present during various stages of the disease, which is of clinical importance as in a real-world setting most subjects received their first-episode psychosis (FEP) diagnosis not until their mid-twenties. In the present study, we measured cerebrospinal fluid (CSF) concentrations of the two pre-synaptic proteins... (More)
Post-mortem studies consistently show evidence of reduced synaptic protein levels in patients with schizophrenia. Clinically high-risk subjects show a steeper decrease in grey matter thickness and in vitro modeling using patient-derived cells implicate excessive synaptic pruning during neurodevelopment as a part of the schizophrenia pathophysiology. However, it is unclear to what extent synapse elimination is present during various stages of the disease, which is of clinical importance as in a real-world setting most subjects received their first-episode psychosis (FEP) diagnosis not until their mid-twenties. In the present study, we measured cerebrospinal fluid (CSF) concentrations of the two pre-synaptic proteins synaptosomal-associated protein 25 (SNAP-25) and synaptotagmin-1 (SYT-1), both of which are increased in conditions of ongoing synaptic degeneration, in 44 FEP subjects (mean age 29.9 years) and 21 healthy controls (25.9 years) using immunoprecipitation mass spectrometry. Neither protein was found to differ between healthy controls and patients, and they showed no correlation with symptom ratings, cognitive performance or antipsychotic medication. Additional studies in high-risk subjects in the early prodromal phase will be needed to address if excessive synapse destruction occurs before the development of overt psychotic symptoms.
(Less)
- author
- author collaboration
- organization
- publishing date
- 2020-06
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Schizophrenia, SNAP-25, Synapse pruning, SYT-1
- in
- IBRO Reports
- volume
- 8
- pages
- 7 pages
- publisher
- Elsevier
- external identifiers
-
- pmid:32490278
- scopus:85085389113
- ISSN
- 2451-8301
- DOI
- 10.1016/j.ibror.2020.04.001
- language
- English
- LU publication?
- yes
- id
- 4caa356f-acdc-47d5-91d5-38d8774ed868
- date added to LUP
- 2020-06-15 14:44:21
- date last changed
- 2024-09-04 23:57:19
@article{4caa356f-acdc-47d5-91d5-38d8774ed868, abstract = {{<p>Post-mortem studies consistently show evidence of reduced synaptic protein levels in patients with schizophrenia. Clinically high-risk subjects show a steeper decrease in grey matter thickness and in vitro modeling using patient-derived cells implicate excessive synaptic pruning during neurodevelopment as a part of the schizophrenia pathophysiology. However, it is unclear to what extent synapse elimination is present during various stages of the disease, which is of clinical importance as in a real-world setting most subjects received their first-episode psychosis (FEP) diagnosis not until their mid-twenties. In the present study, we measured cerebrospinal fluid (CSF) concentrations of the two pre-synaptic proteins synaptosomal-associated protein 25 (SNAP-25) and synaptotagmin-1 (SYT-1), both of which are increased in conditions of ongoing synaptic degeneration, in 44 FEP subjects (mean age 29.9 years) and 21 healthy controls (25.9 years) using immunoprecipitation mass spectrometry. Neither protein was found to differ between healthy controls and patients, and they showed no correlation with symptom ratings, cognitive performance or antipsychotic medication. Additional studies in high-risk subjects in the early prodromal phase will be needed to address if excessive synapse destruction occurs before the development of overt psychotic symptoms.</p>}}, author = {{Xu, Chengai and Sellgren, Carl M. and Fatouros-Bergman, Helena and Piehl, Fredrik and Blennow, Kaj and Zetterberg, Henrik and Brinkmalm, Ann and Santillo, Alexander Frizell and Lundgren, Sofia and Cervenka, Simon and Engberg, Göran and Erhardt, Sophie}}, issn = {{2451-8301}}, keywords = {{Schizophrenia; SNAP-25; Synapse pruning; SYT-1}}, language = {{eng}}, pages = {{136--142}}, publisher = {{Elsevier}}, series = {{IBRO Reports}}, title = {{CSF levels of synaptosomal-associated protein 25 and synaptotagmin-1 in first-episode psychosis subjects}}, url = {{http://dx.doi.org/10.1016/j.ibror.2020.04.001}}, doi = {{10.1016/j.ibror.2020.04.001}}, volume = {{8}}, year = {{2020}}, }