Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Autonomic neuropathy in Type 2 diabetic patients is associated with hyperinsulinaemia and hypertriglyceridaemia

Gottsäter, A. LU ; Ahmed, M. LU ; Fernlund, P. LU and Sundkvist, G. LU (1999) In Diabetic Medicine 16(1). p.49-54
Abstract

Aims: To clarify whether parasympathetic neuropathy in Type 2 diabetic patients is associated with features of the insulin resistance syndrome. Methods: Blood pressures, glycaemic control (HbA(IC)), plasma lipids, residual β-cell function (fasting plasma C-peptide), autonomic nerve function, urinary albumin excretion and glomerular filtration rate (Cr-EDTA clearance) were evaluated in 82 Type 2 diabetic patients (age 61 ± 1 years) 5 years after diagnosis of diabetes. Results: Parasympathetic neuropathy (an abnormal age corrected E/I ratio) was found in 24/82 (29%) patients. After adjustment for body mass index (BMI), patients with parasympathetic neuropathy had elevated fasting plasma C-peptide (P < 0.001) and triglyceride (Tg) (P... (More)

Aims: To clarify whether parasympathetic neuropathy in Type 2 diabetic patients is associated with features of the insulin resistance syndrome. Methods: Blood pressures, glycaemic control (HbA(IC)), plasma lipids, residual β-cell function (fasting plasma C-peptide), autonomic nerve function, urinary albumin excretion and glomerular filtration rate (Cr-EDTA clearance) were evaluated in 82 Type 2 diabetic patients (age 61 ± 1 years) 5 years after diagnosis of diabetes. Results: Parasympathetic neuropathy (an abnormal age corrected E/I ratio) was found in 24/82 (29%) patients. After adjustment for body mass index (BMI), patients with parasympathetic neuropathy had elevated fasting plasma C-peptide (P < 0.001) and triglyceride (Tg) (P < 0.05) levels compared with patients without parasympathetic neuropathy. In addition, the age corrected E/I ratio correlated inversely with Tg (r = -0.31; P < 0.01) and fasting plasma C-peptide (r = -0.32; P < 0.01) in the Type 2 diabetic patients. Conclusion: Autonomic neuropathy 5 years after diagnosis of Type 2 diabetes is associated with an unfavourable metabolic risk profile.

(Less)
Please use this url to cite or link to this publication:
author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Autonomic neuropathy, Complications, Type 2 diabetes mellitus
in
Diabetic Medicine
volume
16
issue
1
pages
6 pages
publisher
Wiley-Blackwell
external identifiers
  • scopus:0032975159
  • pmid:10229293
ISSN
0742-3071
DOI
10.1046/j.1464-5491.1999.00001.x
language
English
LU publication?
yes
id
4cbb064c-1e88-415d-b2fc-b4b37568cbf4
date added to LUP
2020-12-11 14:30:30
date last changed
2025-01-11 01:32:36
@article{4cbb064c-1e88-415d-b2fc-b4b37568cbf4,
  abstract     = {{<p>Aims: To clarify whether parasympathetic neuropathy in Type 2 diabetic patients is associated with features of the insulin resistance syndrome. Methods: Blood pressures, glycaemic control (HbA(IC)), plasma lipids, residual β-cell function (fasting plasma C-peptide), autonomic nerve function, urinary albumin excretion and glomerular filtration rate (Cr-EDTA clearance) were evaluated in 82 Type 2 diabetic patients (age 61 ± 1 years) 5 years after diagnosis of diabetes. Results: Parasympathetic neuropathy (an abnormal age corrected E/I ratio) was found in 24/82 (29%) patients. After adjustment for body mass index (BMI), patients with parasympathetic neuropathy had elevated fasting plasma C-peptide (P &lt; 0.001) and triglyceride (Tg) (P &lt; 0.05) levels compared with patients without parasympathetic neuropathy. In addition, the age corrected E/I ratio correlated inversely with Tg (r = -0.31; P &lt; 0.01) and fasting plasma C-peptide (r = -0.32; P &lt; 0.01) in the Type 2 diabetic patients. Conclusion: Autonomic neuropathy 5 years after diagnosis of Type 2 diabetes is associated with an unfavourable metabolic risk profile.</p>}},
  author       = {{Gottsäter, A. and Ahmed, M. and Fernlund, P. and Sundkvist, G.}},
  issn         = {{0742-3071}},
  keywords     = {{Autonomic neuropathy; Complications; Type 2 diabetes mellitus}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{49--54}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Diabetic Medicine}},
  title        = {{Autonomic neuropathy in Type 2 diabetic patients is associated with hyperinsulinaemia and hypertriglyceridaemia}},
  url          = {{http://dx.doi.org/10.1046/j.1464-5491.1999.00001.x}},
  doi          = {{10.1046/j.1464-5491.1999.00001.x}},
  volume       = {{16}},
  year         = {{1999}},
}