Assembly of Multicompartment Glycopolymer Worms in Aqueous Solution
(2023) In Macromolecules 56(8). p.3195-3203- Abstract
Hierarchical self-assembly is a versatile technique that allows the formation of many complex architectures on the nano- and microscale. However, many of these structures are formed in harsh organic solvents with nonbiocompatible polymers. Here, we investigate in more detail a synthetic path to produce biologically compatible, crosslinked, multicompartment worms (MCWs) in aqueous solution by incorporating thermoresponsive poly-N-isopropylacrylamide (PNIPAM) to direct assembly above the lower critical solution temperature (LCST). As the self-assembly into MCWs can be controlled externally by adjusting the temperature, we can provide new insight into the mechanism of hierarchical self-assembly. The growth of MCWs starting from primary... (More)
Hierarchical self-assembly is a versatile technique that allows the formation of many complex architectures on the nano- and microscale. However, many of these structures are formed in harsh organic solvents with nonbiocompatible polymers. Here, we investigate in more detail a synthetic path to produce biologically compatible, crosslinked, multicompartment worms (MCWs) in aqueous solution by incorporating thermoresponsive poly-N-isopropylacrylamide (PNIPAM) to direct assembly above the lower critical solution temperature (LCST). As the self-assembly into MCWs can be controlled externally by adjusting the temperature, we can provide new insight into the mechanism of hierarchical self-assembly. The growth of MCWs starting from primary micelles was observed above the LCST using in situ small-angle neutron scattering, dynamic light scattering, atomic force microscopy, and phase contrast microscopy.
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- author
- Lovegrove, Jordan T. ; Humphreys, Ben A. LU ; Wong, Chin Ken ; de Campo, Liliana ; Wang, Anna ; Garvey, Christopher J. LU and Stenzel, Martina H.
- organization
- publishing date
- 2023
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Macromolecules
- volume
- 56
- issue
- 8
- pages
- 9 pages
- publisher
- The American Chemical Society (ACS)
- external identifiers
-
- scopus:85152704531
- ISSN
- 0024-9297
- DOI
- 10.1021/acs.macromol.2c02466
- language
- English
- LU publication?
- yes
- id
- 4cccb17f-f136-4ee0-8d53-eb06692eee51
- date added to LUP
- 2023-08-15 10:05:59
- date last changed
- 2023-11-08 08:40:17
@article{4cccb17f-f136-4ee0-8d53-eb06692eee51, abstract = {{<p>Hierarchical self-assembly is a versatile technique that allows the formation of many complex architectures on the nano- and microscale. However, many of these structures are formed in harsh organic solvents with nonbiocompatible polymers. Here, we investigate in more detail a synthetic path to produce biologically compatible, crosslinked, multicompartment worms (MCWs) in aqueous solution by incorporating thermoresponsive poly-N-isopropylacrylamide (PNIPAM) to direct assembly above the lower critical solution temperature (LCST). As the self-assembly into MCWs can be controlled externally by adjusting the temperature, we can provide new insight into the mechanism of hierarchical self-assembly. The growth of MCWs starting from primary micelles was observed above the LCST using in situ small-angle neutron scattering, dynamic light scattering, atomic force microscopy, and phase contrast microscopy.</p>}}, author = {{Lovegrove, Jordan T. and Humphreys, Ben A. and Wong, Chin Ken and de Campo, Liliana and Wang, Anna and Garvey, Christopher J. and Stenzel, Martina H.}}, issn = {{0024-9297}}, language = {{eng}}, number = {{8}}, pages = {{3195--3203}}, publisher = {{The American Chemical Society (ACS)}}, series = {{Macromolecules}}, title = {{Assembly of Multicompartment Glycopolymer Worms in Aqueous Solution}}, url = {{http://dx.doi.org/10.1021/acs.macromol.2c02466}}, doi = {{10.1021/acs.macromol.2c02466}}, volume = {{56}}, year = {{2023}}, }