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Assembly of Multicompartment Glycopolymer Worms in Aqueous Solution

Lovegrove, Jordan T. ; Humphreys, Ben A. LU ; Wong, Chin Ken ; de Campo, Liliana ; Wang, Anna ; Garvey, Christopher J. LU orcid and Stenzel, Martina H. (2023) In Macromolecules 56(8). p.3195-3203
Abstract

Hierarchical self-assembly is a versatile technique that allows the formation of many complex architectures on the nano- and microscale. However, many of these structures are formed in harsh organic solvents with nonbiocompatible polymers. Here, we investigate in more detail a synthetic path to produce biologically compatible, crosslinked, multicompartment worms (MCWs) in aqueous solution by incorporating thermoresponsive poly-N-isopropylacrylamide (PNIPAM) to direct assembly above the lower critical solution temperature (LCST). As the self-assembly into MCWs can be controlled externally by adjusting the temperature, we can provide new insight into the mechanism of hierarchical self-assembly. The growth of MCWs starting from primary... (More)

Hierarchical self-assembly is a versatile technique that allows the formation of many complex architectures on the nano- and microscale. However, many of these structures are formed in harsh organic solvents with nonbiocompatible polymers. Here, we investigate in more detail a synthetic path to produce biologically compatible, crosslinked, multicompartment worms (MCWs) in aqueous solution by incorporating thermoresponsive poly-N-isopropylacrylamide (PNIPAM) to direct assembly above the lower critical solution temperature (LCST). As the self-assembly into MCWs can be controlled externally by adjusting the temperature, we can provide new insight into the mechanism of hierarchical self-assembly. The growth of MCWs starting from primary micelles was observed above the LCST using in situ small-angle neutron scattering, dynamic light scattering, atomic force microscopy, and phase contrast microscopy.

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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Macromolecules
volume
56
issue
8
pages
9 pages
publisher
The American Chemical Society (ACS)
external identifiers
  • scopus:85152704531
ISSN
0024-9297
DOI
10.1021/acs.macromol.2c02466
language
English
LU publication?
yes
id
4cccb17f-f136-4ee0-8d53-eb06692eee51
date added to LUP
2023-08-15 10:05:59
date last changed
2025-10-14 09:06:48
@article{4cccb17f-f136-4ee0-8d53-eb06692eee51,
  abstract     = {{<p>Hierarchical self-assembly is a versatile technique that allows the formation of many complex architectures on the nano- and microscale. However, many of these structures are formed in harsh organic solvents with nonbiocompatible polymers. Here, we investigate in more detail a synthetic path to produce biologically compatible, crosslinked, multicompartment worms (MCWs) in aqueous solution by incorporating thermoresponsive poly-N-isopropylacrylamide (PNIPAM) to direct assembly above the lower critical solution temperature (LCST). As the self-assembly into MCWs can be controlled externally by adjusting the temperature, we can provide new insight into the mechanism of hierarchical self-assembly. The growth of MCWs starting from primary micelles was observed above the LCST using in situ small-angle neutron scattering, dynamic light scattering, atomic force microscopy, and phase contrast microscopy.</p>}},
  author       = {{Lovegrove, Jordan T. and Humphreys, Ben A. and Wong, Chin Ken and de Campo, Liliana and Wang, Anna and Garvey, Christopher J. and Stenzel, Martina H.}},
  issn         = {{0024-9297}},
  language     = {{eng}},
  number       = {{8}},
  pages        = {{3195--3203}},
  publisher    = {{The American Chemical Society (ACS)}},
  series       = {{Macromolecules}},
  title        = {{Assembly of Multicompartment Glycopolymer Worms in Aqueous Solution}},
  url          = {{http://dx.doi.org/10.1021/acs.macromol.2c02466}},
  doi          = {{10.1021/acs.macromol.2c02466}},
  volume       = {{56}},
  year         = {{2023}},
}