Tired of Diabetes Genetics? Circadian Rhythms and Diabetes: The MTNR1B Story?
(2012) In Current Diabetes Reports 12(6). p.667-672- Abstract
- Circadian rhythms are ubiquitous in biological systems and regulate metabolic processes throughout the body. Misalliance of these circadian rhythms and the systems they regulate has a profound impact on hormone levels and increases risk of developing metabolic diseases. Melatonin, a hormone secreted by the pineal gland, is one of the major signaling molecules used by the master circadian oscillator to entrain downstream circadian rhythms. Several recent genetic studies have pointed out that a common variant in the gene that encodes the melatonin receptor 2 (MTNR1B) is associated with impaired glucose homeostasis, reduced insulin secretion, and an increased risk of developing type 2 diabetes. Here, we try to review the role of this receptor... (More)
- Circadian rhythms are ubiquitous in biological systems and regulate metabolic processes throughout the body. Misalliance of these circadian rhythms and the systems they regulate has a profound impact on hormone levels and increases risk of developing metabolic diseases. Melatonin, a hormone secreted by the pineal gland, is one of the major signaling molecules used by the master circadian oscillator to entrain downstream circadian rhythms. Several recent genetic studies have pointed out that a common variant in the gene that encodes the melatonin receptor 2 (MTNR1B) is associated with impaired glucose homeostasis, reduced insulin secretion, and an increased risk of developing type 2 diabetes. Here, we try to review the role of this receptor and its signaling pathways in respect to glucose homeostasis and development of the disease. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3123619
- author
- Nagorny, Cecilia LU and Lyssenko, Valeriya LU
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Current Diabetes Reports
- volume
- 12
- issue
- 6
- pages
- 667 - 672
- publisher
- Current Science, Inc.
- external identifiers
-
- wos:000310706500005
- pmid:23015324
- scopus:84870710555
- pmid:23015324
- ISSN
- 1539-0829
- DOI
- 10.1007/s11892-012-0327-y
- language
- English
- LU publication?
- yes
- id
- 4ce263e5-e6c2-4454-acd9-e037c241807d (old id 3123619)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/23015324?dopt=Abstract
- date added to LUP
- 2016-04-04 07:10:21
- date last changed
- 2024-01-12 00:22:25
@article{4ce263e5-e6c2-4454-acd9-e037c241807d,
abstract = {{Circadian rhythms are ubiquitous in biological systems and regulate metabolic processes throughout the body. Misalliance of these circadian rhythms and the systems they regulate has a profound impact on hormone levels and increases risk of developing metabolic diseases. Melatonin, a hormone secreted by the pineal gland, is one of the major signaling molecules used by the master circadian oscillator to entrain downstream circadian rhythms. Several recent genetic studies have pointed out that a common variant in the gene that encodes the melatonin receptor 2 (MTNR1B) is associated with impaired glucose homeostasis, reduced insulin secretion, and an increased risk of developing type 2 diabetes. Here, we try to review the role of this receptor and its signaling pathways in respect to glucose homeostasis and development of the disease.}},
author = {{Nagorny, Cecilia and Lyssenko, Valeriya}},
issn = {{1539-0829}},
language = {{eng}},
number = {{6}},
pages = {{667--672}},
publisher = {{Current Science, Inc.}},
series = {{Current Diabetes Reports}},
title = {{Tired of Diabetes Genetics? Circadian Rhythms and Diabetes: The MTNR1B Story?}},
url = {{http://dx.doi.org/10.1007/s11892-012-0327-y}},
doi = {{10.1007/s11892-012-0327-y}},
volume = {{12}},
year = {{2012}},
}