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Circulating fibrosis biomarkers and risk of atrial fibrillation : The Cardiovascular Health Study (CHS)

Rosenberg, Michael A. ; Maziarz, Marlena LU ; Tan, Alex Y. ; Glazer, Nicole L. ; Zieman, Susan J. ; Kizer, Jorge R. ; Ix, Joachim H. ; Djousse, Luc ; Siscovick, David S. and Heckbert, Susan R. , et al. (2014) In American Heart Journal 167(5).
Abstract

Background Cardiac fibrosis is thought to play a central role in the pathogenesis of atrial fibrillation (AF). Retrospective studies have suggested that circulating fibrosis biomarkers are associated with AF, but prospective studies are limited. Methods We measured circulating levels of 2 fibrosis biomarkers, procollagen type III, N-terminal propeptide (PIIINP) and transforming growth factor β1 among participants of the CHS, a population-based study of older Americans. We used Cox proportional hazards and competing risks models to examine adjusted risk of incident AF over a median follow-up of 8.8 years. Results Levels of PIIINP were assessed in 2,935 participants, of whom 767 developed AF. Compared with the median PIIINP level (4.45... (More)

Background Cardiac fibrosis is thought to play a central role in the pathogenesis of atrial fibrillation (AF). Retrospective studies have suggested that circulating fibrosis biomarkers are associated with AF, but prospective studies are limited. Methods We measured circulating levels of 2 fibrosis biomarkers, procollagen type III, N-terminal propeptide (PIIINP) and transforming growth factor β1 among participants of the CHS, a population-based study of older Americans. We used Cox proportional hazards and competing risks models to examine adjusted risk of incident AF over a median follow-up of 8.8 years. Results Levels of PIIINP were assessed in 2,935 participants, of whom 767 developed AF. Compared with the median PIIINP level (4.45 μg/L), adjusted hazard ratios (95% CIs) were 0.85 (0.72-1.00) at the 10th percentile, 0.93 (0.88-0.99) at the 25th percentile, 1.04 (0.95-1.04) at the 75th percentile, and 1.07 (0.90-1.26) at the 90th. Transforming growth factor β1 levels, assessed in 1,538 participants with 408 cases of incident AF, were not associated with AF risk. Conclusion In older adults, PIIINP levels were associated with risk of incident AF in a complex manner, with an association that appeared to be positive up to median levels but with little relationship beyond that. Further studies are required to confirm and possibly delineate the mechanism for this relationship.

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publishing date
type
Contribution to journal
publication status
published
subject
in
American Heart Journal
volume
167
issue
5
publisher
Mosby-Elsevier
external identifiers
  • pmid:24766983
  • scopus:84899525953
ISSN
0002-8703
DOI
10.1016/j.ahj.2014.01.010
language
English
LU publication?
no
id
4d20873f-a415-45a2-8527-ba47fbb7e071
date added to LUP
2019-08-05 13:16:02
date last changed
2024-04-16 18:15:35
@article{4d20873f-a415-45a2-8527-ba47fbb7e071,
  abstract     = {{<p>Background Cardiac fibrosis is thought to play a central role in the pathogenesis of atrial fibrillation (AF). Retrospective studies have suggested that circulating fibrosis biomarkers are associated with AF, but prospective studies are limited. Methods We measured circulating levels of 2 fibrosis biomarkers, procollagen type III, N-terminal propeptide (PIIINP) and transforming growth factor β1 among participants of the CHS, a population-based study of older Americans. We used Cox proportional hazards and competing risks models to examine adjusted risk of incident AF over a median follow-up of 8.8 years. Results Levels of PIIINP were assessed in 2,935 participants, of whom 767 developed AF. Compared with the median PIIINP level (4.45 μg/L), adjusted hazard ratios (95% CIs) were 0.85 (0.72-1.00) at the 10th percentile, 0.93 (0.88-0.99) at the 25th percentile, 1.04 (0.95-1.04) at the 75th percentile, and 1.07 (0.90-1.26) at the 90th. Transforming growth factor β1 levels, assessed in 1,538 participants with 408 cases of incident AF, were not associated with AF risk. Conclusion In older adults, PIIINP levels were associated with risk of incident AF in a complex manner, with an association that appeared to be positive up to median levels but with little relationship beyond that. Further studies are required to confirm and possibly delineate the mechanism for this relationship.</p>}},
  author       = {{Rosenberg, Michael A. and Maziarz, Marlena and Tan, Alex Y. and Glazer, Nicole L. and Zieman, Susan J. and Kizer, Jorge R. and Ix, Joachim H. and Djousse, Luc and Siscovick, David S. and Heckbert, Susan R. and Mukamal, Kenneth J.}},
  issn         = {{0002-8703}},
  language     = {{eng}},
  month        = {{01}},
  number       = {{5}},
  publisher    = {{Mosby-Elsevier}},
  series       = {{American Heart Journal}},
  title        = {{Circulating fibrosis biomarkers and risk of atrial fibrillation : The Cardiovascular Health Study (CHS)}},
  url          = {{http://dx.doi.org/10.1016/j.ahj.2014.01.010}},
  doi          = {{10.1016/j.ahj.2014.01.010}},
  volume       = {{167}},
  year         = {{2014}},
}