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The Association Between APOE epsilon 4 and Alzheimer-type Dementia Among Memory Clinic Patients is Confined to those with a Higher Education. The DESCRIPA Study

Vermeiren, Angelique P. A.; Bosma, Hans; Visser, Pieter-Jelle; Zeegers, Maurice P.; Graff, Caroline; Ewers, Michael; Frisoni, Giovanni B.; Froelich, Lutz; Hampel, Harald and Jones, Roy W., et al. (2013) In Journal of Alzheimer's Disease 35(2). p.241-246
Abstract
We assessed the interaction between the APOE epsilon 4 allele and education level in the etiology of Alzheimer's disease (AD) among memory clinic patients from the multicenter DESCRIPA study. Subjects (n = 544) were followed for 1 to 5 years. We used Cox's stratified survival modeling, adjusted for age, gender, and center. APOE epsilon 4 predicted the onset of AD-type dementia in middle (HR 3.45 95% CI 1.79-6.65, n = 222) and high (HR 3.67 95% CI 1.36-9.89, n = 139) but not in low educated subjects (HR 0.81, 95% CI 0.38-1.72, n = 183). This suggests that mechanisms in developing Alzheimer-type dementia may differ between educational groups that raises questions related to Alzheimer-type dementia prevention.
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@article{4d4b76cd-c369-4e98-944f-a66106143ded,
  abstract     = {We assessed the interaction between the APOE epsilon 4 allele and education level in the etiology of Alzheimer's disease (AD) among memory clinic patients from the multicenter DESCRIPA study. Subjects (n = 544) were followed for 1 to 5 years. We used Cox's stratified survival modeling, adjusted for age, gender, and center. APOE epsilon 4 predicted the onset of AD-type dementia in middle (HR 3.45 95% CI 1.79-6.65, n = 222) and high (HR 3.67 95% CI 1.36-9.89, n = 139) but not in low educated subjects (HR 0.81, 95% CI 0.38-1.72, n = 183). This suggests that mechanisms in developing Alzheimer-type dementia may differ between educational groups that raises questions related to Alzheimer-type dementia prevention.},
  author       = {Vermeiren, Angelique P. A. and Bosma, Hans and Visser, Pieter-Jelle and Zeegers, Maurice P. and Graff, Caroline and Ewers, Michael and Frisoni, Giovanni B. and Froelich, Lutz and Hampel, Harald and Jones, Roy W. and Kehoe, Patrick G. and Lenoir, Hermine and Minthon, Lennart and Nobili, Flavio M. and Rikkert, Marcel Olde and Rigaud, Anne-Sophie and Scheltens, Philip and Soininen, Hilkka and Spiru, Luiza and Tsolaki, Magda and Wahlund, Lars-Olof and Vellas, Bruno and Wilcock, Gordon and Elias-Sonnenschein, Lyzel S. and Verhey, Frans R. J.},
  issn         = {1387-2877},
  keyword      = {APOE epsilon 4,cohort study,dementia,education,multicenter study,mild cognitive impairment,socio-economic status},
  language     = {eng},
  number       = {2},
  pages        = {241--246},
  publisher    = {IOS Press},
  series       = {Journal of Alzheimer's Disease},
  title        = {The Association Between APOE epsilon 4 and Alzheimer-type Dementia Among Memory Clinic Patients is Confined to those with a Higher Education. The DESCRIPA Study},
  url          = {http://dx.doi.org/10.3233/JAD-122182},
  volume       = {35},
  year         = {2013},
}