Chemistry of xylopyranosides.
Thorsheim, Karin LU ; Siegbahn, Anna LU ; Johnsson, Richard LU ; Stålbrand, Henrik LU ; Manner, Sophie LU ; Widmalm, Göran and Ellervik, Ulf LU
(2015)
In Carbohydrate Research
418.
p.65-88
- Abstract
- Xylose is one of the few monosaccharidic building blocks that are used by mammalian cells. In comparison with other monosaccharides, xylose is rather unusual and, so far, only found in two different mammalian structures, i.e. in the Notch receptor and as the linker between protein and glycosaminoglycan (GAG) chains in proteoglycans. Interestingly, simple soluble xylopyranosides can not only initiate the biosynthesis of soluble GAG chains but also function as inhibitors of important enzymes in the biosynthesis of proteoglycans. Furthermore, xylose is a major constituent of hemicellulosic xylans and thus one of the most abundant carbohydrates on Earth. Altogether, this has spurred a strong interest in xylose chemistry. The scope of this... (More)
- Xylose is one of the few monosaccharidic building blocks that are used by mammalian cells. In comparison with other monosaccharides, xylose is rather unusual and, so far, only found in two different mammalian structures, i.e. in the Notch receptor and as the linker between protein and glycosaminoglycan (GAG) chains in proteoglycans. Interestingly, simple soluble xylopyranosides can not only initiate the biosynthesis of soluble GAG chains but also function as inhibitors of important enzymes in the biosynthesis of proteoglycans. Furthermore, xylose is a major constituent of hemicellulosic xylans and thus one of the most abundant carbohydrates on Earth. Altogether, this has spurred a strong interest in xylose chemistry. The scope of this review is to describe synthesis of xylopyranosyl donors, as well as protective group chemistry, modifications, and conformational analysis of xylose. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/8235260
- author
- Thorsheim, Karin
LU
; Siegbahn, Anna
LU
; Johnsson, Richard
LU
; Stålbrand, Henrik
LU
; Manner, Sophie
LU
; Widmalm, Göran
and Ellervik, Ulf
LU
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Carbohydrate Research
- volume
- 418
- pages
- 65 - 88
- publisher
- Elsevier
- external identifiers
-
- pmid:26580709
- wos:000366219900009
- scopus:84947423757
- pmid:26580709
- ISSN
- 1873-426X
- DOI
- 10.1016/j.carres.2015.10.004
- language
- English
- LU publication?
- yes
- id
- 4d78e347-4314-4ed3-b44e-e3185bbc6444 (old id 8235260)
- date added to LUP
- 2016-04-01 09:59:42
- date last changed
- 2024-02-04 17:08:59
@article{4d78e347-4314-4ed3-b44e-e3185bbc6444,
abstract = {{Xylose is one of the few monosaccharidic building blocks that are used by mammalian cells. In comparison with other monosaccharides, xylose is rather unusual and, so far, only found in two different mammalian structures, i.e. in the Notch receptor and as the linker between protein and glycosaminoglycan (GAG) chains in proteoglycans. Interestingly, simple soluble xylopyranosides can not only initiate the biosynthesis of soluble GAG chains but also function as inhibitors of important enzymes in the biosynthesis of proteoglycans. Furthermore, xylose is a major constituent of hemicellulosic xylans and thus one of the most abundant carbohydrates on Earth. Altogether, this has spurred a strong interest in xylose chemistry. The scope of this review is to describe synthesis of xylopyranosyl donors, as well as protective group chemistry, modifications, and conformational analysis of xylose.}},
author = {{Thorsheim, Karin and Siegbahn, Anna and Johnsson, Richard and Stålbrand, Henrik and Manner, Sophie and Widmalm, Göran and Ellervik, Ulf}},
issn = {{1873-426X}},
language = {{eng}},
pages = {{65--88}},
publisher = {{Elsevier}},
series = {{Carbohydrate Research}},
title = {{Chemistry of xylopyranosides.}},
url = {{http://dx.doi.org/10.1016/j.carres.2015.10.004}},
doi = {{10.1016/j.carres.2015.10.004}},
volume = {{418}},
year = {{2015}},
}