Flow cytometric S-phase fraction in soft-tissue sarcoma: prognostic importance analysed in 160 patients
(1997) In British Journal of Cancer 75(1). p.94-100- Abstract
- We could determine the S-phase fraction (SPF) by flow cytometric DNA analysis of paraffin archival material in 160 of 260 patients with soft-tissue sarcoma of extremity and trunk wall. The prognostic value of SPF was compared with other clinicopathological factors. The median follow-up time was 16 (6-31) years. In a univariate analysis, deep tumour location, increasing tumour size and histological malignancy grade, microscopic tumour necrosis, vascular invasion, DNA non-diploidy and high SPF (>3.0%) were associated with poor metastasis-free survival. In a multivariate analysis, microscopic tumour necrosis and high SPF were independently prognostic for metastasis. Used in combination with tumour size, microscopic tumour necrosis and... (More)
- We could determine the S-phase fraction (SPF) by flow cytometric DNA analysis of paraffin archival material in 160 of 260 patients with soft-tissue sarcoma of extremity and trunk wall. The prognostic value of SPF was compared with other clinicopathological factors. The median follow-up time was 16 (6-31) years. In a univariate analysis, deep tumour location, increasing tumour size and histological malignancy grade, microscopic tumour necrosis, vascular invasion, DNA non-diploidy and high SPF (>3.0%) were associated with poor metastasis-free survival. In a multivariate analysis, microscopic tumour necrosis and high SPF were independently prognostic for metastasis. Used in combination with tumour size, microscopic tumour necrosis and vascular invasion, SPF could identify a group of patients with a 5-year metastasis-free survival rate of 0.97. This group constituted one-quarter of all patients. Patients with low SPF who did recur had a prolonged clinical course both as regards metastases and local recurrence. We conclude that SPF is a valuable adjunct in prognostication in soft-tissue sarcoma. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1111408
- author
- Gustafson, Pelle LU ; Fernö, Mårten LU ; Åkerman, Måns LU ; Baldetorp, Bo LU ; Willen, H ; Killander, Dick LU and Rydholm, Anders LU
- organization
- publishing date
- 1997
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Soft tissue, Sarcoma, S Phase, Flow cytometry, Cell cycle, DNA, Ploidy, Prognosis, Human, Malignant tumor
- in
- British Journal of Cancer
- volume
- 75
- issue
- 1
- pages
- 94 - 100
- publisher
- Nature Publishing Group
- external identifiers
-
- pmid:9000604
- scopus:0031012346
- ISSN
- 1532-1827
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Pathology, (Lund) (013030000), Department of Orthopaedics (Lund) (013028000), Oncology, MV (013035000)
- id
- 4d7ac175-e16b-4be4-8a6e-ec0c4795b635 (old id 1111408)
- date added to LUP
- 2016-04-01 12:32:49
- date last changed
- 2022-01-27 06:33:05
@article{4d7ac175-e16b-4be4-8a6e-ec0c4795b635,
abstract = {{We could determine the S-phase fraction (SPF) by flow cytometric DNA analysis of paraffin archival material in 160 of 260 patients with soft-tissue sarcoma of extremity and trunk wall. The prognostic value of SPF was compared with other clinicopathological factors. The median follow-up time was 16 (6-31) years. In a univariate analysis, deep tumour location, increasing tumour size and histological malignancy grade, microscopic tumour necrosis, vascular invasion, DNA non-diploidy and high SPF (>3.0%) were associated with poor metastasis-free survival. In a multivariate analysis, microscopic tumour necrosis and high SPF were independently prognostic for metastasis. Used in combination with tumour size, microscopic tumour necrosis and vascular invasion, SPF could identify a group of patients with a 5-year metastasis-free survival rate of 0.97. This group constituted one-quarter of all patients. Patients with low SPF who did recur had a prolonged clinical course both as regards metastases and local recurrence. We conclude that SPF is a valuable adjunct in prognostication in soft-tissue sarcoma.}},
author = {{Gustafson, Pelle and Fernö, Mårten and Åkerman, Måns and Baldetorp, Bo and Willen, H and Killander, Dick and Rydholm, Anders}},
issn = {{1532-1827}},
keywords = {{Soft tissue; Sarcoma; S Phase; Flow cytometry; Cell cycle; DNA; Ploidy; Prognosis; Human; Malignant tumor}},
language = {{eng}},
number = {{1}},
pages = {{94--100}},
publisher = {{Nature Publishing Group}},
series = {{British Journal of Cancer}},
title = {{Flow cytometric S-phase fraction in soft-tissue sarcoma: prognostic importance analysed in 160 patients}},
volume = {{75}},
year = {{1997}},
}