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Streptococcus bovis-bacteremia: subspecies distribution and association with colorectal cancer : a retrospective cohort study

Öberg, Jonas LU orcid ; Rasmussen, Magnus LU orcid ; Buchwald, Pamela LU ; Nilson, Bo LU orcid and Inghammar, Malin LU (2022) In Epidemiology and Infection 150.
Abstract
This study aimed to describe the incidence of Streptococcus bovis/Streptococcus equinus complex (SBSEC) bacteremia, distribution of the SBSEC subspecies, and their respective association with colorectal cancer (CRC). A population-based retrospective cohort study of all episodes of SBSEC-bacteremia from 2003 to 2018 in Skåne Region, Sweden. Subspecies was determined by whole-genome sequencing. Medical charts were reviewed. The association between subspecies and CRC were analysed using logistic regression. In total 266 episodes of SBSEC-bacteremia were identified and the average annual incidence was 2.0 per 100 000 inhabitants. Of the 236 isolates available for typing, the most common subspecies was S. gallolyticus subsp. pasteurianus 88/236... (More)
This study aimed to describe the incidence of Streptococcus bovis/Streptococcus equinus complex (SBSEC) bacteremia, distribution of the SBSEC subspecies, and their respective association with colorectal cancer (CRC). A population-based retrospective cohort study of all episodes of SBSEC-bacteremia from 2003 to 2018 in Skåne Region, Sweden. Subspecies was determined by whole-genome sequencing. Medical charts were reviewed. The association between subspecies and CRC were analysed using logistic regression. In total 266 episodes of SBSEC-bacteremia were identified and the average annual incidence was 2.0 per 100 000 inhabitants. Of the 236 isolates available for typing, the most common subspecies was S. gallolyticus subsp. pasteurianus 88/236 (37%) followed by S. gallolyticus subsp. gallolyticus 58/236 (25%). In order to determine the risk of cancer following bacteremia, an incidence cohort of 174 episodes without a prior diagnosis of CRC or metastasised cancer was followed for 560 person-years. CRC was found in 13/174 (7%), of which 9 (69%) had S. gallolyticus subsp. gallolyticus-bacteremia. In contrast to other European studies, S. gallolyticus subsp. pasteurianus was the most common cause of SBSEC-bacteremia. CRC diagnosis after bacteremia was strongly associated with S. gallolyticus subsp. gallolyticus-bacteremia. Identification of SBSEC subspecies can guide clinical decision-making regarding CRC work-up following bacteremia. (Less)
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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Epidemiology and Infection
volume
150
article number
e8
publisher
Cambridge University Press
external identifiers
  • scopus:85120989027
ISSN
0950-2688
DOI
10.1017/S0950268821002533
project
Streptococcus bovis och gastrointestinal cancer: Epidemiologi, etiologi och diagnostik
language
English
LU publication?
yes
id
4d8674c7-59c3-47ac-bac6-fac3a5a3c30d
date added to LUP
2022-01-17 16:23:39
date last changed
2025-04-04 14:12:47
@article{4d8674c7-59c3-47ac-bac6-fac3a5a3c30d,
  abstract     = {{This study aimed to describe the incidence of Streptococcus bovis/Streptococcus equinus complex (SBSEC) bacteremia, distribution of the SBSEC subspecies, and their respective association with colorectal cancer (CRC). A population-based retrospective cohort study of all episodes of SBSEC-bacteremia from 2003 to 2018 in Skåne Region, Sweden. Subspecies was determined by whole-genome sequencing. Medical charts were reviewed. The association between subspecies and CRC were analysed using logistic regression. In total 266 episodes of SBSEC-bacteremia were identified and the average annual incidence was 2.0 per 100 000 inhabitants. Of the 236 isolates available for typing, the most common subspecies was S. gallolyticus subsp. pasteurianus 88/236 (37%) followed by S. gallolyticus subsp. gallolyticus 58/236 (25%). In order to determine the risk of cancer following bacteremia, an incidence cohort of 174 episodes without a prior diagnosis of CRC or metastasised cancer was followed for 560 person-years. CRC was found in 13/174 (7%), of which 9 (69%) had S. gallolyticus subsp. gallolyticus-bacteremia. In contrast to other European studies, S. gallolyticus subsp. pasteurianus was the most common cause of SBSEC-bacteremia. CRC diagnosis after bacteremia was strongly associated with S. gallolyticus subsp. gallolyticus-bacteremia. Identification of SBSEC subspecies can guide clinical decision-making regarding CRC work-up following bacteremia.}},
  author       = {{Öberg, Jonas and Rasmussen, Magnus and Buchwald, Pamela and Nilson, Bo and Inghammar, Malin}},
  issn         = {{0950-2688}},
  language     = {{eng}},
  publisher    = {{Cambridge University Press}},
  series       = {{Epidemiology and Infection}},
  title        = {{Streptococcus bovis-bacteremia: subspecies distribution and association with colorectal cancer : a retrospective cohort study}},
  url          = {{http://dx.doi.org/10.1017/S0950268821002533}},
  doi          = {{10.1017/S0950268821002533}},
  volume       = {{150}},
  year         = {{2022}},
}