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Citral a fragrance allergen and irritant

Heydorn, S ; Menne, T ; Andersen, KE ; Bruze, Magnus LU ; Svedman, Cecilia LU ; White, IR and Basketter, DA (2003) In Contact Dermatitis 49(1). p.32-36
Abstract
Citral is a well known contact allergen and a contact irritant. Routine patch testing in the past may have been restricted because of possible irritant (IR) patch test responses. 586 consecutive patients, with hand eczema, were patch tested with a selection of fragrances including citral 2% petrolatum and the European standard series. 28 of the patients showed a positive patch test reaction (+ to +++) to citral and 82 at least 1 IR patch test reaction and no positive patch test reaction to citral. A statistically significant association between a positive patch test reaction to citral and positive patch test reactions to other fragrances compared with IR reactions (n = 82) was established. The difference regarding fragrance history found... (More)
Citral is a well known contact allergen and a contact irritant. Routine patch testing in the past may have been restricted because of possible irritant (IR) patch test responses. 586 consecutive patients, with hand eczema, were patch tested with a selection of fragrances including citral 2% petrolatum and the European standard series. 28 of the patients showed a positive patch test reaction (+ to +++) to citral and 82 at least 1 IR patch test reaction and no positive patch test reaction to citral. A statistically significant association between a positive patch test reaction to citral and positive patch test reactions to other fragrances compared with IR reactions (n = 82) was established. The difference regarding fragrance history found between those with IR and positive reactions to citral was not significant. Citral could be an allergen and/or irritant, worthy of further more extensive studies. (Less)
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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
patch testing, fragrance, contact irritant, citral, contact allergen
in
Contact Dermatitis
volume
49
issue
1
pages
32 - 36
publisher
Wiley-Blackwell
external identifiers
  • wos:000186891900006
  • pmid:14641118
  • scopus:0346753594
ISSN
0105-1873
DOI
10.1111/j.0105-1873.2003.00144.x
language
English
LU publication?
yes
id
4d906fee-9b57-437f-a385-0baad701bf69 (old id 293928)
date added to LUP
2016-04-01 12:16:15
date last changed
2025-10-14 12:33:40
@article{4d906fee-9b57-437f-a385-0baad701bf69,
  abstract     = {{Citral is a well known contact allergen and a contact irritant. Routine patch testing in the past may have been restricted because of possible irritant (IR) patch test responses. 586 consecutive patients, with hand eczema, were patch tested with a selection of fragrances including citral 2% petrolatum and the European standard series. 28 of the patients showed a positive patch test reaction (+ to +++) to citral and 82 at least 1 IR patch test reaction and no positive patch test reaction to citral. A statistically significant association between a positive patch test reaction to citral and positive patch test reactions to other fragrances compared with IR reactions (n = 82) was established. The difference regarding fragrance history found between those with IR and positive reactions to citral was not significant. Citral could be an allergen and/or irritant, worthy of further more extensive studies.}},
  author       = {{Heydorn, S and Menne, T and Andersen, KE and Bruze, Magnus and Svedman, Cecilia and White, IR and Basketter, DA}},
  issn         = {{0105-1873}},
  keywords     = {{patch testing; fragrance; contact irritant; citral; contact allergen}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{32--36}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Contact Dermatitis}},
  title        = {{Citral a fragrance allergen and irritant}},
  url          = {{http://dx.doi.org/10.1111/j.0105-1873.2003.00144.x}},
  doi          = {{10.1111/j.0105-1873.2003.00144.x}},
  volume       = {{49}},
  year         = {{2003}},
}