Vitamin d status in patients operated for primary hyperparathyroidism: comparison of patients from southern and northern europe.
(2013) In International Journal of Endocrinology 2013.- Abstract
- Aim. The interaction between vitamin D deficiency and primary hyperparathyroidism (PHPT) is not fully understood. The aim of this study was to investigate whether patients with PHPT from Spain and Sweden differed in vitamin D status and PHPT disease activity before and after surgery. Methods. We compared two cohorts of postmenopausal women from Spain (n = 126) and Sweden (n = 128) that had first-time surgery for sporadic, uniglandular PHPT. Biochemical variables reflecting bone metabolism and disease activity, including levels of 25-hydroxy vitamin D3 (25(OH)D) and bone mineral density, BMD, were measured pre- and one year postoperatively. Results. Median preoperative 25(OH)D levels were lower, and adenoma weight, PTH, and urinary calcium... (More)
- Aim. The interaction between vitamin D deficiency and primary hyperparathyroidism (PHPT) is not fully understood. The aim of this study was to investigate whether patients with PHPT from Spain and Sweden differed in vitamin D status and PHPT disease activity before and after surgery. Methods. We compared two cohorts of postmenopausal women from Spain (n = 126) and Sweden (n = 128) that had first-time surgery for sporadic, uniglandular PHPT. Biochemical variables reflecting bone metabolism and disease activity, including levels of 25-hydroxy vitamin D3 (25(OH)D) and bone mineral density, BMD, were measured pre- and one year postoperatively. Results. Median preoperative 25(OH)D levels were lower, and adenoma weight, PTH, and urinary calcium levels were higher in the Spanish cohort. The Spanish patients had higher preoperative levels of PTH (13.5 versus 11.0 pmol/L, P < 0.001), urinary calcium (7.3 versus 4.1 mmol/L, P < 0.001), and heavier adenomas (620 versus 500 g, P < 0.001). The mean increase in BMD was higher in patients from Spain and in patients with vitamin D deficiency one year after surgery. Conclusion. Postmenopasual women with PHPT from Spain had a more advanced disease and lower vitamin 25(OH)D levels. Improvement in bone density one year after surgery was higher in patients with preoperative vitamin D deficiency. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4005257
- author
- Nordenström, Erik LU ; Sitges-Serra, Antonio ; Sancho, Joan J ; Thier, Mark LU and Almquist, Martin LU
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- in
- International Journal of Endocrinology
- volume
- 2013
- article number
- 164939
- publisher
- Hindawi Limited
- external identifiers
-
- wos:000323258200001
- pmid:23986777
- scopus:84883197750
- pmid:23986777
- ISSN
- 1687-8337
- DOI
- 10.1155/2013/164939
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Emergency medicine/Medicine/Surgery (013240200), Surgery (Lund) (013009000)
- id
- 4daa74c0-1900-4d52-acac-df2e396a0593 (old id 4005257)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/23986777?dopt=Abstract
- date added to LUP
- 2016-04-01 10:20:39
- date last changed
- 2022-01-25 22:18:43
@article{4daa74c0-1900-4d52-acac-df2e396a0593, abstract = {{Aim. The interaction between vitamin D deficiency and primary hyperparathyroidism (PHPT) is not fully understood. The aim of this study was to investigate whether patients with PHPT from Spain and Sweden differed in vitamin D status and PHPT disease activity before and after surgery. Methods. We compared two cohorts of postmenopausal women from Spain (n = 126) and Sweden (n = 128) that had first-time surgery for sporadic, uniglandular PHPT. Biochemical variables reflecting bone metabolism and disease activity, including levels of 25-hydroxy vitamin D3 (25(OH)D) and bone mineral density, BMD, were measured pre- and one year postoperatively. Results. Median preoperative 25(OH)D levels were lower, and adenoma weight, PTH, and urinary calcium levels were higher in the Spanish cohort. The Spanish patients had higher preoperative levels of PTH (13.5 versus 11.0 pmol/L, P < 0.001), urinary calcium (7.3 versus 4.1 mmol/L, P < 0.001), and heavier adenomas (620 versus 500 g, P < 0.001). The mean increase in BMD was higher in patients from Spain and in patients with vitamin D deficiency one year after surgery. Conclusion. Postmenopasual women with PHPT from Spain had a more advanced disease and lower vitamin 25(OH)D levels. Improvement in bone density one year after surgery was higher in patients with preoperative vitamin D deficiency.}}, author = {{Nordenström, Erik and Sitges-Serra, Antonio and Sancho, Joan J and Thier, Mark and Almquist, Martin}}, issn = {{1687-8337}}, language = {{eng}}, publisher = {{Hindawi Limited}}, series = {{International Journal of Endocrinology}}, title = {{Vitamin d status in patients operated for primary hyperparathyroidism: comparison of patients from southern and northern europe.}}, url = {{https://lup.lub.lu.se/search/files/1766809/4286363.pdf}}, doi = {{10.1155/2013/164939}}, volume = {{2013}}, year = {{2013}}, }