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Vitamin d status in patients operated for primary hyperparathyroidism: comparison of patients from southern and northern europe.

Nordenström, Erik LU ; Sitges-Serra, Antonio; Sancho, Joan J; Thier, Mark LU and Almquist, Martin LU (2013) In International Journal of Endocrinology 2013.
Abstract
Aim. The interaction between vitamin D deficiency and primary hyperparathyroidism (PHPT) is not fully understood. The aim of this study was to investigate whether patients with PHPT from Spain and Sweden differed in vitamin D status and PHPT disease activity before and after surgery. Methods. We compared two cohorts of postmenopausal women from Spain (n = 126) and Sweden (n = 128) that had first-time surgery for sporadic, uniglandular PHPT. Biochemical variables reflecting bone metabolism and disease activity, including levels of 25-hydroxy vitamin D3 (25(OH)D) and bone mineral density, BMD, were measured pre- and one year postoperatively. Results. Median preoperative 25(OH)D levels were lower, and adenoma weight, PTH, and urinary calcium... (More)
Aim. The interaction between vitamin D deficiency and primary hyperparathyroidism (PHPT) is not fully understood. The aim of this study was to investigate whether patients with PHPT from Spain and Sweden differed in vitamin D status and PHPT disease activity before and after surgery. Methods. We compared two cohorts of postmenopausal women from Spain (n = 126) and Sweden (n = 128) that had first-time surgery for sporadic, uniglandular PHPT. Biochemical variables reflecting bone metabolism and disease activity, including levels of 25-hydroxy vitamin D3 (25(OH)D) and bone mineral density, BMD, were measured pre- and one year postoperatively. Results. Median preoperative 25(OH)D levels were lower, and adenoma weight, PTH, and urinary calcium levels were higher in the Spanish cohort. The Spanish patients had higher preoperative levels of PTH (13.5 versus 11.0 pmol/L, P < 0.001), urinary calcium (7.3 versus 4.1 mmol/L, P < 0.001), and heavier adenomas (620 versus 500 g, P < 0.001). The mean increase in BMD was higher in patients from Spain and in patients with vitamin D deficiency one year after surgery. Conclusion. Postmenopasual women with PHPT from Spain had a more advanced disease and lower vitamin 25(OH)D levels. Improvement in bone density one year after surgery was higher in patients with preoperative vitamin D deficiency. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
International Journal of Endocrinology
volume
2013
publisher
Hindawi Publishing Corporation
external identifiers
  • wos:000323258200001
  • pmid:23986777
  • scopus:84883197750
ISSN
1687-8337
DOI
10.1155/2013/164939
language
English
LU publication?
yes
id
4daa74c0-1900-4d52-acac-df2e396a0593 (old id 4005257)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23986777?dopt=Abstract
date added to LUP
2013-09-05 14:04:16
date last changed
2019-02-20 01:57:34
@article{4daa74c0-1900-4d52-acac-df2e396a0593,
  abstract     = {Aim. The interaction between vitamin D deficiency and primary hyperparathyroidism (PHPT) is not fully understood. The aim of this study was to investigate whether patients with PHPT from Spain and Sweden differed in vitamin D status and PHPT disease activity before and after surgery. Methods. We compared two cohorts of postmenopausal women from Spain (n = 126) and Sweden (n = 128) that had first-time surgery for sporadic, uniglandular PHPT. Biochemical variables reflecting bone metabolism and disease activity, including levels of 25-hydroxy vitamin D3 (25(OH)D) and bone mineral density, BMD, were measured pre- and one year postoperatively. Results. Median preoperative 25(OH)D levels were lower, and adenoma weight, PTH, and urinary calcium levels were higher in the Spanish cohort. The Spanish patients had higher preoperative levels of PTH (13.5 versus 11.0 pmol/L, P &lt; 0.001), urinary calcium (7.3 versus 4.1 mmol/L, P &lt; 0.001), and heavier adenomas (620 versus 500 g, P &lt; 0.001). The mean increase in BMD was higher in patients from Spain and in patients with vitamin D deficiency one year after surgery. Conclusion. Postmenopasual women with PHPT from Spain had a more advanced disease and lower vitamin 25(OH)D levels. Improvement in bone density one year after surgery was higher in patients with preoperative vitamin D deficiency.},
  articleno    = {164939},
  author       = {Nordenström, Erik and Sitges-Serra, Antonio and Sancho, Joan J and Thier, Mark and Almquist, Martin},
  issn         = {1687-8337},
  language     = {eng},
  publisher    = {Hindawi Publishing Corporation},
  series       = {International Journal of Endocrinology},
  title        = {Vitamin d status in patients operated for primary hyperparathyroidism: comparison of patients from southern and northern europe.},
  url          = {http://dx.doi.org/10.1155/2013/164939},
  volume       = {2013},
  year         = {2013},
}