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Incidence and risk of venous thromboembolism in patients with verified arterial thrombosis: a population study based on 23 796 consecutive autopsies

Eliasson, A.; Bergqvist, D.; Bjorck, M.; Acosta, Stefan LU ; Sternby, Nils LU and Ogren, M. (2006) In Journal of Thrombosis and Haemostasis 4(9). p.1897-1902
Abstract
Background: The relationship between atherothrombotic disease and venous thromboembolism (VTE) remains unclear. Patients and methods: In a cohort of 23 796 consecutive autopsies, performed using a standardized procedure and representing 84% of all in-hospital deaths between 1970 and 1982 in an urban Swedish population, we investigated the relationship between verified arterial thrombosis and VTE, with the hypothesis that patients with thrombosis in major artery segments have increased odds of VTE. Results: We found an increased risk of VTE in patients with arterial thrombosis (Odds ratio; OR adjusted for gender and age 1.4, 95% confidence interval; CI 1.3-1.5) (P < 0.001). Patients with cervico-cranial and peripheral artery thrombosis... (More)
Background: The relationship between atherothrombotic disease and venous thromboembolism (VTE) remains unclear. Patients and methods: In a cohort of 23 796 consecutive autopsies, performed using a standardized procedure and representing 84% of all in-hospital deaths between 1970 and 1982 in an urban Swedish population, we investigated the relationship between verified arterial thrombosis and VTE, with the hypothesis that patients with thrombosis in major artery segments have increased odds of VTE. Results: We found an increased risk of VTE in patients with arterial thrombosis (Odds ratio; OR adjusted for gender and age 1.4, 95% confidence interval; CI 1.3-1.5) (P < 0.001). Patients with cervico-cranial and peripheral artery thrombosis had an excess risk even when controlling for age and major concomitant diseases. A negative association between coronary thrombosis and VTE in the univariate analysis (OR 0.7; 95% CI 0.6-0.8) (P < 0.001), was less pronounced in the multivariate analysis (OR 0.8; 95% CI 0.7-1.0) (P = 0.016). Conclusions: A positive association between atherothrombosis and VTE was confirmed, except in patients with coronary thrombosis, where IHD as competing death cause is a possible confounder. Our findings indicate a potential for directed prevention, but may also imply similarities in etiology. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
venous thromboembolism, embolism, pulmonary, epidemiology, arterial thrombosis, coronary thrombosis
in
Journal of Thrombosis and Haemostasis
volume
4
issue
9
pages
1897 - 1902
publisher
Federation of European Neuroscience Societies and Blackwell Publishing Ltd
external identifiers
  • wos:000239702400008
  • scopus:33747179842
ISSN
1538-7933
DOI
10.1111/j.1538-7836.2006.02152.x
language
English
LU publication?
yes
id
4db0d95c-da26-4c32-a49a-b4935cb6067c (old id 686253)
date added to LUP
2007-12-27 13:12:12
date last changed
2019-09-04 01:49:16
@article{4db0d95c-da26-4c32-a49a-b4935cb6067c,
  abstract     = {Background: The relationship between atherothrombotic disease and venous thromboembolism (VTE) remains unclear. Patients and methods: In a cohort of 23 796 consecutive autopsies, performed using a standardized procedure and representing 84% of all in-hospital deaths between 1970 and 1982 in an urban Swedish population, we investigated the relationship between verified arterial thrombosis and VTE, with the hypothesis that patients with thrombosis in major artery segments have increased odds of VTE. Results: We found an increased risk of VTE in patients with arterial thrombosis (Odds ratio; OR adjusted for gender and age 1.4, 95% confidence interval; CI 1.3-1.5) (P &lt; 0.001). Patients with cervico-cranial and peripheral artery thrombosis had an excess risk even when controlling for age and major concomitant diseases. A negative association between coronary thrombosis and VTE in the univariate analysis (OR 0.7; 95% CI 0.6-0.8) (P &lt; 0.001), was less pronounced in the multivariate analysis (OR 0.8; 95% CI 0.7-1.0) (P = 0.016). Conclusions: A positive association between atherothrombosis and VTE was confirmed, except in patients with coronary thrombosis, where IHD as competing death cause is a possible confounder. Our findings indicate a potential for directed prevention, but may also imply similarities in etiology.},
  author       = {Eliasson, A. and Bergqvist, D. and Bjorck, M. and Acosta, Stefan and Sternby, Nils and Ogren, M.},
  issn         = {1538-7933},
  keyword      = {venous thromboembolism,embolism,pulmonary,epidemiology,arterial thrombosis,coronary thrombosis},
  language     = {eng},
  number       = {9},
  pages        = {1897--1902},
  publisher    = {Federation of European Neuroscience Societies and Blackwell Publishing Ltd},
  series       = {Journal of Thrombosis and Haemostasis},
  title        = {Incidence and risk of venous thromboembolism in patients with verified arterial thrombosis: a population study based on 23 796 consecutive autopsies},
  url          = {http://dx.doi.org/10.1111/j.1538-7836.2006.02152.x},
  volume       = {4},
  year         = {2006},
}