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Ibuprofen attenuates the inflammatory response and allows formation of migratory neuroblasts from grafted stem cells after traumatic brain injury

Wallenquist, U; Holmqvist, K; Hånell, A; Marklund, N LU ; Hillered, L and Forsberg-Nilsson, K (2012) In Restorative Neurology and Neuroscience 30(1). p.9-19
Abstract

PURPOSE: There is hope for neural stem and progenitor cells (NSPC) to enhance regeneration when transplanted to the injured brain after traumatic brain injury (TBI). So far, the therapeutic effects of NSPC transplantation have been hampered mainly by the notable death of the transplanted cells. Neuroinflammation may lead to additional cell death after TBI and we hypothesized that survival of grafted NSPC could be enhanced by anti-inflammatory treatment.

METHODS: Mice that were subjected to controlled cortical impact TBI and grafted with NSPC, were treated with the non-steroidal anti-inflammatory drug ibuprofen.

RESULTS: Ibuprofen was found to down-regulate the TBI-induced inflammatory response. In addition, migrating... (More)

PURPOSE: There is hope for neural stem and progenitor cells (NSPC) to enhance regeneration when transplanted to the injured brain after traumatic brain injury (TBI). So far, the therapeutic effects of NSPC transplantation have been hampered mainly by the notable death of the transplanted cells. Neuroinflammation may lead to additional cell death after TBI and we hypothesized that survival of grafted NSPC could be enhanced by anti-inflammatory treatment.

METHODS: Mice that were subjected to controlled cortical impact TBI and grafted with NSPC, were treated with the non-steroidal anti-inflammatory drug ibuprofen.

RESULTS: Ibuprofen was found to down-regulate the TBI-induced inflammatory response. In addition, migrating neuroblasts from transplanted cells were observed near the contusion and in the ipsilateral hippocampus in ibuprofen-treated animals only, suggesting that the anti-inflammatory treatment had beneficial effects on graft survival and/or differentiation. However, Morris Water Maze performance or TBI-induced tissue loss was not influenced by ibuprofen treatment.

CONCLUSIONS: Our data suggests that anti-inflammatory strategies may be a complement to enhance the outcome for the cell transplants following TBI.

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organization
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Contribution to journal
publication status
published
keywords
Actins, Analysis of Variance, Animals, Anti-Inflammatory Agents, Non-Steroidal, Brain Injuries, Cell Count, Cell Movement, Cells, Cultured, Disease Models, Animal, Embryo, Mammalian, Encephalitis, Galectin 3, Gene Expression Regulation, Green Fluorescent Proteins, Ibuprofen, Intercellular Adhesion Molecule-1, Maze Learning, Mice, Mice, Inbred C57BL, Mice, Transgenic, Microtubule-Associated Proteins, Neural Stem Cells, Neuropeptides, Stem Cell Transplantation, Time Factors
in
Restorative Neurology and Neuroscience
volume
30
issue
1
pages
9 - 19
publisher
IOS Press
external identifiers
  • scopus:84858209269
ISSN
1878-3627
DOI
10.3233/RNN-2011-0606
language
English
LU publication?
no
id
4db3a4c6-6b18-4274-b91d-9c7b9806ec54
date added to LUP
2018-03-03 15:27:28
date last changed
2018-10-29 10:42:04
@article{4db3a4c6-6b18-4274-b91d-9c7b9806ec54,
  abstract     = {<p>PURPOSE: There is hope for neural stem and progenitor cells (NSPC) to enhance regeneration when transplanted to the injured brain after traumatic brain injury (TBI). So far, the therapeutic effects of NSPC transplantation have been hampered mainly by the notable death of the transplanted cells. Neuroinflammation may lead to additional cell death after TBI and we hypothesized that survival of grafted NSPC could be enhanced by anti-inflammatory treatment.</p><p>METHODS: Mice that were subjected to controlled cortical impact TBI and grafted with NSPC, were treated with the non-steroidal anti-inflammatory drug ibuprofen.</p><p>RESULTS: Ibuprofen was found to down-regulate the TBI-induced inflammatory response. In addition, migrating neuroblasts from transplanted cells were observed near the contusion and in the ipsilateral hippocampus in ibuprofen-treated animals only, suggesting that the anti-inflammatory treatment had beneficial effects on graft survival and/or differentiation. However, Morris Water Maze performance or TBI-induced tissue loss was not influenced by ibuprofen treatment.</p><p>CONCLUSIONS: Our data suggests that anti-inflammatory strategies may be a complement to enhance the outcome for the cell transplants following TBI.</p>},
  author       = {Wallenquist, U and Holmqvist, K and Hånell, A and Marklund, N and Hillered, L and Forsberg-Nilsson, K},
  issn         = {1878-3627},
  keyword      = {Actins,Analysis of Variance,Animals,Anti-Inflammatory Agents, Non-Steroidal,Brain Injuries,Cell Count,Cell Movement,Cells, Cultured,Disease Models, Animal,Embryo, Mammalian,Encephalitis,Galectin 3,Gene Expression Regulation,Green Fluorescent Proteins,Ibuprofen,Intercellular Adhesion Molecule-1,Maze Learning,Mice,Mice, Inbred C57BL,Mice, Transgenic,Microtubule-Associated Proteins,Neural Stem Cells,Neuropeptides,Stem Cell Transplantation,Time Factors},
  language     = {eng},
  number       = {1},
  pages        = {9--19},
  publisher    = {IOS Press},
  series       = {Restorative Neurology and Neuroscience},
  title        = {Ibuprofen attenuates the inflammatory response and allows formation of migratory neuroblasts from grafted stem cells after traumatic brain injury},
  url          = {http://dx.doi.org/10.3233/RNN-2011-0606},
  volume       = {30},
  year         = {2012},
}