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Chronic hyperbaric exposure activates proinflammatory mediators in humans

Ersson, Anders LU ; Walles, Maria LU ; Ohlsson, K and Ekholm, A (2002) In Journal of Applied Physiology 92(6). p.2375-2380
Abstract
Decompression illness (DCI) is an illness affecting divers subjected to reductions in ambient pressure. Besides a mechanical explanation to DCI, an inflammatory mechanism has been suggested. In this study, levels of interleukin (IL)-8, IL-6, IL-1 receptor antagonist (IL-1ra), secretory leukocyte protease inhibitor (SLPI), and neutrophil gelatinase-associated lipocalcin (NGAL) were measured in divers before and after a 2-mo period of daily diving. The divers were military conscripts and completed their diving period with no clinical symptoms of DCI. We found no change in IL-6 and IL1-ra but did find an increase in IL-8 and NGAL together with a decrease in SLPI levels. The findings suggest an inflammatory activation. This activation is not... (More)
Decompression illness (DCI) is an illness affecting divers subjected to reductions in ambient pressure. Besides a mechanical explanation to DCI, an inflammatory mechanism has been suggested. In this study, levels of interleukin (IL)-8, IL-6, IL-1 receptor antagonist (IL-1ra), secretory leukocyte protease inhibitor (SLPI), and neutrophil gelatinase-associated lipocalcin (NGAL) were measured in divers before and after a 2-mo period of daily diving. The divers were military conscripts and completed their diving period with no clinical symptoms of DCI. We found no change in IL-6 and IL1-ra but did find an increase in IL-8 and NGAL together with a decrease in SLPI levels. The findings suggest an inflammatory activation. This activation is not severe because no changes in IL-6 or IL-1ra were found. The increase in NGAL and IL-8 levels were interpreted as a sign of leukocyte activation. The decreased SLPI levels suggest an influence on the inflammatory defense mechanism. All in all, the findings of this study show a compensated activation of the inflammatory defense mechanism without loss of homeostasis of the inflammatory system. (Less)
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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
decompression, diving, inflammatory activation
in
Journal of Applied Physiology
volume
92
issue
6
pages
2375 - 2380
publisher
American Physiological Society
external identifiers
  • pmid:12015350
  • wos:000175739200020
  • scopus:0036082172
ISSN
1522-1601
DOI
10.1152/japplphysiol.00705.2001
language
English
LU publication?
yes
id
4dce52fd-babb-40ae-b02d-557ea3285744 (old id 337183)
date added to LUP
2016-04-01 12:30:09
date last changed
2022-04-21 08:16:10
@article{4dce52fd-babb-40ae-b02d-557ea3285744,
  abstract     = {{Decompression illness (DCI) is an illness affecting divers subjected to reductions in ambient pressure. Besides a mechanical explanation to DCI, an inflammatory mechanism has been suggested. In this study, levels of interleukin (IL)-8, IL-6, IL-1 receptor antagonist (IL-1ra), secretory leukocyte protease inhibitor (SLPI), and neutrophil gelatinase-associated lipocalcin (NGAL) were measured in divers before and after a 2-mo period of daily diving. The divers were military conscripts and completed their diving period with no clinical symptoms of DCI. We found no change in IL-6 and IL1-ra but did find an increase in IL-8 and NGAL together with a decrease in SLPI levels. The findings suggest an inflammatory activation. This activation is not severe because no changes in IL-6 or IL-1ra were found. The increase in NGAL and IL-8 levels were interpreted as a sign of leukocyte activation. The decreased SLPI levels suggest an influence on the inflammatory defense mechanism. All in all, the findings of this study show a compensated activation of the inflammatory defense mechanism without loss of homeostasis of the inflammatory system.}},
  author       = {{Ersson, Anders and Walles, Maria and Ohlsson, K and Ekholm, A}},
  issn         = {{1522-1601}},
  keywords     = {{decompression; diving; inflammatory activation}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{2375--2380}},
  publisher    = {{American Physiological Society}},
  series       = {{Journal of Applied Physiology}},
  title        = {{Chronic hyperbaric exposure activates proinflammatory mediators in humans}},
  url          = {{http://dx.doi.org/10.1152/japplphysiol.00705.2001}},
  doi          = {{10.1152/japplphysiol.00705.2001}},
  volume       = {{92}},
  year         = {{2002}},
}