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Incidence and prevalence of systemic sclerosis globally : A comprehensive systematic review and meta-analysis

Bairkdar, Majd ; Rossides, Marios ; Westerlind, Helga ; Hesselstrand, Roger LU ; Arkema, Elizabeth V. and Holmqvist, Marie (2021) In Rheumatology (United Kingdom) 60(7). p.3121-3133
Abstract

Objectives: We aimed to conduct a systematic review and meta-analysis on the incidence and prevalence of SSc covering the entire literature. Methods: This study followed the recommendations of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement of 2009. We conducted a systematic search in MEDLINE, Web of Science and Embase to identify articles reporting incidence and/or prevalence of SSc. Two authors conducted the search, reviewed articles for inclusion and extracted relevant data. We used random-effects models to estimate the pooled prevalence and incidence of SSc and performed subgroup analyses by sex, case definition and region to investigate heterogeneity. We explored the association between... (More)

Objectives: We aimed to conduct a systematic review and meta-analysis on the incidence and prevalence of SSc covering the entire literature. Methods: This study followed the recommendations of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement of 2009. We conducted a systematic search in MEDLINE, Web of Science and Embase to identify articles reporting incidence and/or prevalence of SSc. Two authors conducted the search, reviewed articles for inclusion and extracted relevant data. We used random-effects models to estimate the pooled prevalence and incidence of SSc and performed subgroup analyses by sex, case definition and region to investigate heterogeneity. We explored the association between calendar period and reported estimates using meta-regression. Results: Among 6983 unique records identified, we included 61 studies of prevalence and 39 studies of incidence in the systematic review. The overall pooled prevalence of SSc was 17.6 (95% CI 15.1, 20.5) per 100 000 and the overall pooled incidence rate of SSc was 1.4 (95% CI 1.1, 1.9) per 100 000 person-years. We observed significant regional variations in reported estimates; studies conducted in North America reported considerably higher estimates than other regions. The pooled incidence and prevalence in women were five times higher than in men. More recent studies reported higher estimates than older ones. Conclusion: In this comprehensive review of the incidence and prevalence of SSc across the world, there was large heterogeneity among estimates, which should be taken into consideration when interpreting the results.

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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
incidence, meta-analysis, prevalence, systematic review, systemic sclerosis
in
Rheumatology (United Kingdom)
volume
60
issue
7
pages
13 pages
publisher
Oxford University Press
external identifiers
  • scopus:85110550935
  • pmid:33630060
ISSN
1462-0324
DOI
10.1093/rheumatology/keab190
language
English
LU publication?
yes
id
4dfa51df-9a69-4e27-89cf-a0681e0d0e67
date added to LUP
2021-09-09 13:48:10
date last changed
2024-11-17 08:51:01
@article{4dfa51df-9a69-4e27-89cf-a0681e0d0e67,
  abstract     = {{<p>Objectives: We aimed to conduct a systematic review and meta-analysis on the incidence and prevalence of SSc covering the entire literature. Methods: This study followed the recommendations of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement of 2009. We conducted a systematic search in MEDLINE, Web of Science and Embase to identify articles reporting incidence and/or prevalence of SSc. Two authors conducted the search, reviewed articles for inclusion and extracted relevant data. We used random-effects models to estimate the pooled prevalence and incidence of SSc and performed subgroup analyses by sex, case definition and region to investigate heterogeneity. We explored the association between calendar period and reported estimates using meta-regression. Results: Among 6983 unique records identified, we included 61 studies of prevalence and 39 studies of incidence in the systematic review. The overall pooled prevalence of SSc was 17.6 (95% CI 15.1, 20.5) per 100 000 and the overall pooled incidence rate of SSc was 1.4 (95% CI 1.1, 1.9) per 100 000 person-years. We observed significant regional variations in reported estimates; studies conducted in North America reported considerably higher estimates than other regions. The pooled incidence and prevalence in women were five times higher than in men. More recent studies reported higher estimates than older ones. Conclusion: In this comprehensive review of the incidence and prevalence of SSc across the world, there was large heterogeneity among estimates, which should be taken into consideration when interpreting the results. </p>}},
  author       = {{Bairkdar, Majd and Rossides, Marios and Westerlind, Helga and Hesselstrand, Roger and Arkema, Elizabeth V. and Holmqvist, Marie}},
  issn         = {{1462-0324}},
  keywords     = {{incidence; meta-analysis; prevalence; systematic review; systemic sclerosis}},
  language     = {{eng}},
  number       = {{7}},
  pages        = {{3121--3133}},
  publisher    = {{Oxford University Press}},
  series       = {{Rheumatology (United Kingdom)}},
  title        = {{Incidence and prevalence of systemic sclerosis globally : A comprehensive systematic review and meta-analysis}},
  url          = {{http://dx.doi.org/10.1093/rheumatology/keab190}},
  doi          = {{10.1093/rheumatology/keab190}},
  volume       = {{60}},
  year         = {{2021}},
}