Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Fusion genes in angiomatoid fibrous histiocytoma

Hansén Nord, Karolin LU ; Micci, Francesca ; Meis-Kindblom, Jeanne M ; Kindblom, Lars-Gunnar ; Bacchini, Patrizia ; Mandahl, Nils LU ; Mertens, Fredrik LU and Panagopoulos, Ioannis LU (2007) In Cancer Letters 251(1). p.158-163
Abstract

Angiomatoid fibrous histiocytoma (AFH) is a rare soft tissue tumor of low malignant potential and uncertain differentiation. Only three genetically investigated cases of AFH have been reported. Two of them displayed a FUS-ATF1 fusion gene and one showed an EWSR1-ATF1 chimera. Using RT-PCR analysis, we have identified the EWSR1-ATF1 fusion transcript, and delineated the genomic breakpoints, in two new cases of AFH. Previously, the EWSR1-ATF1 fusion protein has been suggested to activate expression of the MITF-M transcript, and therefore the expression pattern of the MITF gene was studied. The MITF-M transcript was not detected in either AFH, in line with the finding that the co-activator SOX10 was not expressed. Thus, of the five AFH... (More)

Angiomatoid fibrous histiocytoma (AFH) is a rare soft tissue tumor of low malignant potential and uncertain differentiation. Only three genetically investigated cases of AFH have been reported. Two of them displayed a FUS-ATF1 fusion gene and one showed an EWSR1-ATF1 chimera. Using RT-PCR analysis, we have identified the EWSR1-ATF1 fusion transcript, and delineated the genomic breakpoints, in two new cases of AFH. Previously, the EWSR1-ATF1 fusion protein has been suggested to activate expression of the MITF-M transcript, and therefore the expression pattern of the MITF gene was studied. The MITF-M transcript was not detected in either AFH, in line with the finding that the co-activator SOX10 was not expressed. Thus, of the five AFH that have been molecularly analyzed to date, two have displayed a FUS-ATF1 fusion gene and three have shown an EWSR1-ATF1 chimera. There is no apparent correlation between the type of fusion gene and clinicopathologic features. Nonetheless, RT-PCR for these fusion transcripts remains a valuable diagnostic adjunct in the distinction between AFH and other soft tissue tumors or metastases that may simulate it.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Activating Transcription Factor 1, Base Sequence, Bone Neoplasms, Calmodulin-Binding Proteins, Child, Clavicle, DNA-Binding Proteins, Histiocytoma, Malignant Fibrous, Humans, Male, Nuclear Proteins, Oncogene Proteins, Fusion, RNA-Binding Protein FUS, RNA-Binding Proteins, Reverse Transcriptase Polymerase Chain Reaction, Sequence Analysis, DNA, Spinal Neoplasms, Spine, Transcription Factors, Case Reports, Journal Article, Research Support, Non-U.S. Gov't
in
Cancer Letters
volume
251
issue
1
pages
6 pages
publisher
Elsevier
external identifiers
  • wos:000246637700016
  • scopus:34247149350
  • pmid:17188428
ISSN
1872-7980
DOI
10.1016/j.canlet.2006.11.014
language
English
LU publication?
yes
id
4dfdab6c-e09d-4afd-b8a1-b9774391453f (old id 659671)
date added to LUP
2016-04-01 16:10:31
date last changed
2022-02-12 20:20:25
@article{4dfdab6c-e09d-4afd-b8a1-b9774391453f,
  abstract     = {{<p>Angiomatoid fibrous histiocytoma (AFH) is a rare soft tissue tumor of low malignant potential and uncertain differentiation. Only three genetically investigated cases of AFH have been reported. Two of them displayed a FUS-ATF1 fusion gene and one showed an EWSR1-ATF1 chimera. Using RT-PCR analysis, we have identified the EWSR1-ATF1 fusion transcript, and delineated the genomic breakpoints, in two new cases of AFH. Previously, the EWSR1-ATF1 fusion protein has been suggested to activate expression of the MITF-M transcript, and therefore the expression pattern of the MITF gene was studied. The MITF-M transcript was not detected in either AFH, in line with the finding that the co-activator SOX10 was not expressed. Thus, of the five AFH that have been molecularly analyzed to date, two have displayed a FUS-ATF1 fusion gene and three have shown an EWSR1-ATF1 chimera. There is no apparent correlation between the type of fusion gene and clinicopathologic features. Nonetheless, RT-PCR for these fusion transcripts remains a valuable diagnostic adjunct in the distinction between AFH and other soft tissue tumors or metastases that may simulate it.</p>}},
  author       = {{Hansén Nord, Karolin and Micci, Francesca and Meis-Kindblom, Jeanne M and Kindblom, Lars-Gunnar and Bacchini, Patrizia and Mandahl, Nils and Mertens, Fredrik and Panagopoulos, Ioannis}},
  issn         = {{1872-7980}},
  keywords     = {{Activating Transcription Factor 1; Base Sequence; Bone Neoplasms; Calmodulin-Binding Proteins; Child; Clavicle; DNA-Binding Proteins; Histiocytoma, Malignant Fibrous; Humans; Male; Nuclear Proteins; Oncogene Proteins, Fusion; RNA-Binding Protein FUS; RNA-Binding Proteins; Reverse Transcriptase Polymerase Chain Reaction; Sequence Analysis, DNA; Spinal Neoplasms; Spine; Transcription Factors; Case Reports; Journal Article; Research Support, Non-U.S. Gov't}},
  language     = {{eng}},
  month        = {{06}},
  number       = {{1}},
  pages        = {{158--163}},
  publisher    = {{Elsevier}},
  series       = {{Cancer Letters}},
  title        = {{Fusion genes in angiomatoid fibrous histiocytoma}},
  url          = {{http://dx.doi.org/10.1016/j.canlet.2006.11.014}},
  doi          = {{10.1016/j.canlet.2006.11.014}},
  volume       = {{251}},
  year         = {{2007}},
}