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Cognitive decline and quality of life in incident Parkinson's disease : The role of attention

Lawson, Rachael A; Yarnall, Alison J; Duncan, Gordon W; Breen, David P; Khoo, Tien K; Williams-Gray, Caroline H; Barker, Roger A LU ; Collerton, Daniel; Taylor, John-Paul and Burn, David J, et al. (2016) In Parkinsonism and Related Disorders 27. p.47-53
Abstract

INTRODUCTION: Parkinson's disease dementia (PDD) is associated with poorer quality of life (QoL). Prior to the onset of PDD, many patients experience progressive cognitive impairment. There is a paucity of longitudinal studies investigating the effects of cognitive decline on QoL. This study aimed to determine the longitudinal impact of cognitive change on QoL in an incident PD cohort.

METHODS: Recently diagnosed patients with PD (n = 212) completed a schedule of neuropsychological assessments and QoL measures; these were repeated after 18 (n = 190) and 36 months (n = 158). Mild cognitive impairment (PD-MCI) was classified with reference to the Movement Disorder Society criteria. Principal component analysis was used to reduce 10... (More)

INTRODUCTION: Parkinson's disease dementia (PDD) is associated with poorer quality of life (QoL). Prior to the onset of PDD, many patients experience progressive cognitive impairment. There is a paucity of longitudinal studies investigating the effects of cognitive decline on QoL. This study aimed to determine the longitudinal impact of cognitive change on QoL in an incident PD cohort.

METHODS: Recently diagnosed patients with PD (n = 212) completed a schedule of neuropsychological assessments and QoL measures; these were repeated after 18 (n = 190) and 36 months (n = 158). Mild cognitive impairment (PD-MCI) was classified with reference to the Movement Disorder Society criteria. Principal component analysis was used to reduce 10 neuropsychological tests to three cognitive factors: attention, memory/executive function, and global cognition.

RESULTS: Baseline PD-MCI was a significant contributor to QoL (β = 0.2, p < 0.01). For those subjects (9%) who developed dementia, cognitive function had a much greater impact on QoL (β = 10.3, p < 0.05). Multivariate modelling showed attentional deficits had the strongest predictive power (β = -2.3, p < 0.01); brief global tests only modestly predicted decline in QoL (β = -0.4, p < 0.01).

CONCLUSIONS: PD-MCI was associated with poorer QoL over three years follow up. Cognitive impairment had a greater impact on QoL in individuals who developed dementia over follow-up. Impaired attention was a significant determinant of QoL in PD. Interventions which improve concentration and attention in those with PD could potentially improve QoL.

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type
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published
keywords
Journal Article
in
Parkinsonism and Related Disorders
volume
27
pages
7 pages
publisher
Elsevier
external identifiers
  • scopus:84963650298
ISSN
1873-5126
DOI
10.1016/j.parkreldis.2016.04.009
language
English
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no
id
4e391f2f-648a-48a2-a582-9eec913e4ef1
date added to LUP
2016-11-23 13:09:01
date last changed
2017-11-12 04:26:23
@article{4e391f2f-648a-48a2-a582-9eec913e4ef1,
  abstract     = {<p>INTRODUCTION: Parkinson's disease dementia (PDD) is associated with poorer quality of life (QoL). Prior to the onset of PDD, many patients experience progressive cognitive impairment. There is a paucity of longitudinal studies investigating the effects of cognitive decline on QoL. This study aimed to determine the longitudinal impact of cognitive change on QoL in an incident PD cohort.</p><p>METHODS: Recently diagnosed patients with PD (n = 212) completed a schedule of neuropsychological assessments and QoL measures; these were repeated after 18 (n = 190) and 36 months (n = 158). Mild cognitive impairment (PD-MCI) was classified with reference to the Movement Disorder Society criteria. Principal component analysis was used to reduce 10 neuropsychological tests to three cognitive factors: attention, memory/executive function, and global cognition.</p><p>RESULTS: Baseline PD-MCI was a significant contributor to QoL (β = 0.2, p &lt; 0.01). For those subjects (9%) who developed dementia, cognitive function had a much greater impact on QoL (β = 10.3, p &lt; 0.05). Multivariate modelling showed attentional deficits had the strongest predictive power (β = -2.3, p &lt; 0.01); brief global tests only modestly predicted decline in QoL (β = -0.4, p &lt; 0.01).</p><p>CONCLUSIONS: PD-MCI was associated with poorer QoL over three years follow up. Cognitive impairment had a greater impact on QoL in individuals who developed dementia over follow-up. Impaired attention was a significant determinant of QoL in PD. Interventions which improve concentration and attention in those with PD could potentially improve QoL.</p>},
  author       = {Lawson, Rachael A and Yarnall, Alison J and Duncan, Gordon W and Breen, David P and Khoo, Tien K and Williams-Gray, Caroline H and Barker, Roger A and Collerton, Daniel and Taylor, John-Paul and Burn, David J and , },
  issn         = {1873-5126},
  keyword      = {Journal Article},
  language     = {eng},
  pages        = {47--53},
  publisher    = {Elsevier},
  series       = {Parkinsonism and Related Disorders},
  title        = {Cognitive decline and quality of life in incident Parkinson's disease : The role of attention},
  url          = {http://dx.doi.org/10.1016/j.parkreldis.2016.04.009},
  volume       = {27},
  year         = {2016},
}