Functional Mannose-Binding Lectin Haplotype Variants are Associated with Alzheimer's Disease
(2013) In Journal of Alzheimer's Disease 35(1). p.121-127- Abstract
- Mannan-Binding lectin (MBL) is a serum lectin and an important constituent of the innate immune system. Processes linked to the innate immune response have previously been implicated in Alzheimer's disease (AD). MBL is associated with blood vessels in the brain and AD patients demonstrate lower MBL levels in the cerebrospinal fluid compared to controls. We investigated six single nucleotide polymorphisms, linked to MBL deficiency, in the corresponding MBL2 gene in AD patients and controls. Two MBL2 haplotypes, LXP and LYQ, were significantly associated with AD risk (OR = 1.6, p = 0.01 and OR = 1.5, p = 0.02, respectively). The present study is the first investigating MBL2 genotypes and haplotypes in relation to AD. Our findings support... (More)
- Mannan-Binding lectin (MBL) is a serum lectin and an important constituent of the innate immune system. Processes linked to the innate immune response have previously been implicated in Alzheimer's disease (AD). MBL is associated with blood vessels in the brain and AD patients demonstrate lower MBL levels in the cerebrospinal fluid compared to controls. We investigated six single nucleotide polymorphisms, linked to MBL deficiency, in the corresponding MBL2 gene in AD patients and controls. Two MBL2 haplotypes, LXP and LYQ, were significantly associated with AD risk (OR = 1.6, p = 0.01 and OR = 1.5, p = 0.02, respectively). The present study is the first investigating MBL2 genotypes and haplotypes in relation to AD. Our findings support that the MBL2 gene impact the disease risk. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3749537
- author
- Sjolander, Annica ; Minthon, Lennart LU ; Nuytinck, Lieve ; Vanmechelen, Eugeen ; Blennow, Kaj and Nilsson, Staffan
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Alzheimer's disease, cerebrospinal fluid, gene, immune response, Mannan-Binding lectin, single nucleotide polymorphism
- in
- Journal of Alzheimer's Disease
- volume
- 35
- issue
- 1
- pages
- 121 - 127
- publisher
- IOS Press
- external identifiers
-
- wos:000316940000010
- scopus:84876352131
- ISSN
- 1387-2877
- DOI
- 10.3233/JAD-122044
- language
- English
- LU publication?
- yes
- id
- 4ebfa10f-e5bf-4325-8e80-08fc48d35065 (old id 3749537)
- date added to LUP
- 2016-04-01 10:29:28
- date last changed
- 2022-04-04 18:36:02
@article{4ebfa10f-e5bf-4325-8e80-08fc48d35065,
abstract = {{Mannan-Binding lectin (MBL) is a serum lectin and an important constituent of the innate immune system. Processes linked to the innate immune response have previously been implicated in Alzheimer's disease (AD). MBL is associated with blood vessels in the brain and AD patients demonstrate lower MBL levels in the cerebrospinal fluid compared to controls. We investigated six single nucleotide polymorphisms, linked to MBL deficiency, in the corresponding MBL2 gene in AD patients and controls. Two MBL2 haplotypes, LXP and LYQ, were significantly associated with AD risk (OR = 1.6, p = 0.01 and OR = 1.5, p = 0.02, respectively). The present study is the first investigating MBL2 genotypes and haplotypes in relation to AD. Our findings support that the MBL2 gene impact the disease risk.}},
author = {{Sjolander, Annica and Minthon, Lennart and Nuytinck, Lieve and Vanmechelen, Eugeen and Blennow, Kaj and Nilsson, Staffan}},
issn = {{1387-2877}},
keywords = {{Alzheimer's disease; cerebrospinal fluid; gene; immune response; Mannan-Binding lectin; single nucleotide polymorphism}},
language = {{eng}},
number = {{1}},
pages = {{121--127}},
publisher = {{IOS Press}},
series = {{Journal of Alzheimer's Disease}},
title = {{Functional Mannose-Binding Lectin Haplotype Variants are Associated with Alzheimer's Disease}},
url = {{http://dx.doi.org/10.3233/JAD-122044}},
doi = {{10.3233/JAD-122044}},
volume = {{35}},
year = {{2013}},
}