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Functional Mannose-Binding Lectin Haplotype Variants are Associated with Alzheimer's Disease

Sjolander, Annica; Minthon, Lennart LU ; Nuytinck, Lieve; Vanmechelen, Eugeen; Blennow, Kaj and Nilsson, Staffan (2013) In Journal of Alzheimer's Disease 35(1). p.121-127
Abstract
Mannan-Binding lectin (MBL) is a serum lectin and an important constituent of the innate immune system. Processes linked to the innate immune response have previously been implicated in Alzheimer's disease (AD). MBL is associated with blood vessels in the brain and AD patients demonstrate lower MBL levels in the cerebrospinal fluid compared to controls. We investigated six single nucleotide polymorphisms, linked to MBL deficiency, in the corresponding MBL2 gene in AD patients and controls. Two MBL2 haplotypes, LXP and LYQ, were significantly associated with AD risk (OR = 1.6, p = 0.01 and OR = 1.5, p = 0.02, respectively). The present study is the first investigating MBL2 genotypes and haplotypes in relation to AD. Our findings support... (More)
Mannan-Binding lectin (MBL) is a serum lectin and an important constituent of the innate immune system. Processes linked to the innate immune response have previously been implicated in Alzheimer's disease (AD). MBL is associated with blood vessels in the brain and AD patients demonstrate lower MBL levels in the cerebrospinal fluid compared to controls. We investigated six single nucleotide polymorphisms, linked to MBL deficiency, in the corresponding MBL2 gene in AD patients and controls. Two MBL2 haplotypes, LXP and LYQ, were significantly associated with AD risk (OR = 1.6, p = 0.01 and OR = 1.5, p = 0.02, respectively). The present study is the first investigating MBL2 genotypes and haplotypes in relation to AD. Our findings support that the MBL2 gene impact the disease risk. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Alzheimer's disease, cerebrospinal fluid, gene, immune response, Mannan-Binding lectin, single nucleotide polymorphism
in
Journal of Alzheimer's Disease
volume
35
issue
1
pages
121 - 127
publisher
IOS Press
external identifiers
  • wos:000316940000010
  • scopus:84876352131
ISSN
1387-2877
DOI
10.3233/JAD-122044
language
English
LU publication?
yes
id
4ebfa10f-e5bf-4325-8e80-08fc48d35065 (old id 3749537)
date added to LUP
2013-06-03 08:39:08
date last changed
2019-08-14 01:16:46
@article{4ebfa10f-e5bf-4325-8e80-08fc48d35065,
  abstract     = {Mannan-Binding lectin (MBL) is a serum lectin and an important constituent of the innate immune system. Processes linked to the innate immune response have previously been implicated in Alzheimer's disease (AD). MBL is associated with blood vessels in the brain and AD patients demonstrate lower MBL levels in the cerebrospinal fluid compared to controls. We investigated six single nucleotide polymorphisms, linked to MBL deficiency, in the corresponding MBL2 gene in AD patients and controls. Two MBL2 haplotypes, LXP and LYQ, were significantly associated with AD risk (OR = 1.6, p = 0.01 and OR = 1.5, p = 0.02, respectively). The present study is the first investigating MBL2 genotypes and haplotypes in relation to AD. Our findings support that the MBL2 gene impact the disease risk.},
  author       = {Sjolander, Annica and Minthon, Lennart and Nuytinck, Lieve and Vanmechelen, Eugeen and Blennow, Kaj and Nilsson, Staffan},
  issn         = {1387-2877},
  keyword      = {Alzheimer's disease,cerebrospinal fluid,gene,immune response,Mannan-Binding lectin,single nucleotide polymorphism},
  language     = {eng},
  number       = {1},
  pages        = {121--127},
  publisher    = {IOS Press},
  series       = {Journal of Alzheimer's Disease},
  title        = {Functional Mannose-Binding Lectin Haplotype Variants are Associated with Alzheimer's Disease},
  url          = {http://dx.doi.org/10.3233/JAD-122044},
  volume       = {35},
  year         = {2013},
}