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Abdominal aortic aneurysm growth rates are not correlated to body surface area in screened men

Starck, Joachim LU ; Lundgren, Fredrik ; Pärsson, Håkan LU ; Gottsäter, Anders LU and Holst, Jan LU (2023) In International Angiology 42(1). p.65-72
Abstract

BACKGROUND: Screening for abdominal aortic aneurysm (AAA) in 65-year-old males reduces aneurysm related mortality. Infrarenal aortic diameter (IAD) has been shown to correlate to body surface area (BSA) which could influence diagnostic criteria for AAA. This study investigates whether AAA growth rates are also dependent on BSA, as that might have potential effects on surveillance of small AAAs.

METHODS: We conducted a retrospective, single center cohort study of 301 men with screening detected AAA between 2010-2017 with surveillance to 2021. AAA growth rates were analyzed in relation to the subject's BSA, smoking habits, and diabetic disease using a linear mixed-effects model. All men were offered smoking cessation program,... (More)

BACKGROUND: Screening for abdominal aortic aneurysm (AAA) in 65-year-old males reduces aneurysm related mortality. Infrarenal aortic diameter (IAD) has been shown to correlate to body surface area (BSA) which could influence diagnostic criteria for AAA. This study investigates whether AAA growth rates are also dependent on BSA, as that might have potential effects on surveillance of small AAAs.

METHODS: We conducted a retrospective, single center cohort study of 301 men with screening detected AAA between 2010-2017 with surveillance to 2021. AAA growth rates were analyzed in relation to the subject's BSA, smoking habits, and diabetic disease using a linear mixed-effects model. All men were offered smoking cessation program, optimized medical treatment, and advice on physical activity.

RESULTS: The screening program included 28,784 men. Of the 22,819 (79%) attending the examinations, 374 men (1.6%) were found to have an AAA out of which 301 men had undergone two or more examinations during surveillance and were included with a median follow-up of 1846 days (IQR: 1 399). Mean unadjusted AAA growth rate was 1.60 mm/year (95% CI: 1.41-1.80). Diabetes mellitus had a statistically significant negative impact, smoking had a statistically significant positive impact on AAA growth rates whereas no correlation between AAA growth rate and BSA could be found.

CONCLUSIONS: Body surface area could not be found to have a statistically significant correlation to AAA growth rates. The impact of smoking and diabetes on AAA growth rates remains similar to previously reported.

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Please use this url to cite or link to this publication:
author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Male, Humans, Aged, Risk Factors, Cohort Studies, Retrospective Studies, Aortic Aneurysm, Abdominal/diagnostic imaging, Smoking/adverse effects, Diabetes Mellitus, Mass Screening, Ultrasonography
in
International Angiology
volume
42
issue
1
pages
65 - 72
publisher
Minerva Medica
external identifiers
  • scopus:85150000980
  • pmid:36719348
ISSN
1827-1839
DOI
10.23736/S0392-9590.22.04938-0
language
English
LU publication?
yes
id
4ecf5163-aa26-42dd-8741-d9718df7d22e
date added to LUP
2023-08-31 08:59:24
date last changed
2024-04-20 02:15:27
@article{4ecf5163-aa26-42dd-8741-d9718df7d22e,
  abstract     = {{<p>BACKGROUND: Screening for abdominal aortic aneurysm (AAA) in 65-year-old males reduces aneurysm related mortality. Infrarenal aortic diameter (IAD) has been shown to correlate to body surface area (BSA) which could influence diagnostic criteria for AAA. This study investigates whether AAA growth rates are also dependent on BSA, as that might have potential effects on surveillance of small AAAs.</p><p>METHODS: We conducted a retrospective, single center cohort study of 301 men with screening detected AAA between 2010-2017 with surveillance to 2021. AAA growth rates were analyzed in relation to the subject's BSA, smoking habits, and diabetic disease using a linear mixed-effects model. All men were offered smoking cessation program, optimized medical treatment, and advice on physical activity.</p><p>RESULTS: The screening program included 28,784 men. Of the 22,819 (79%) attending the examinations, 374 men (1.6%) were found to have an AAA out of which 301 men had undergone two or more examinations during surveillance and were included with a median follow-up of 1846 days (IQR: 1 399). Mean unadjusted AAA growth rate was 1.60 mm/year (95% CI: 1.41-1.80). Diabetes mellitus had a statistically significant negative impact, smoking had a statistically significant positive impact on AAA growth rates whereas no correlation between AAA growth rate and BSA could be found.</p><p>CONCLUSIONS: Body surface area could not be found to have a statistically significant correlation to AAA growth rates. The impact of smoking and diabetes on AAA growth rates remains similar to previously reported.</p>}},
  author       = {{Starck, Joachim and Lundgren, Fredrik and Pärsson, Håkan and Gottsäter, Anders and Holst, Jan}},
  issn         = {{1827-1839}},
  keywords     = {{Male; Humans; Aged; Risk Factors; Cohort Studies; Retrospective Studies; Aortic Aneurysm, Abdominal/diagnostic imaging; Smoking/adverse effects; Diabetes Mellitus; Mass Screening; Ultrasonography}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{65--72}},
  publisher    = {{Minerva Medica}},
  series       = {{International Angiology}},
  title        = {{Abdominal aortic aneurysm growth rates are not correlated to body surface area in screened men}},
  url          = {{http://dx.doi.org/10.23736/S0392-9590.22.04938-0}},
  doi          = {{10.23736/S0392-9590.22.04938-0}},
  volume       = {{42}},
  year         = {{2023}},
}