3D biomaterial models of human brain disease
Kajtez, Janko LU
; Nilsson, Fredrik
LU
; Fiorenzano, Alessandro
LU
; Parmar, Malin
LU
and Emnéus, Jenny
LU
(2021)
In Neurochemistry International
147.
- Abstract
Inherent limitations of the traditional approaches to study brain function and disease, such as rodent models and 2D cell culture platforms, have led to the development of 3D in vitro cell culture systems. These systems, products of multidisciplinary efforts encompassing stem cell biology, materials engineering, and biofabrication, have quickly shown great potential to mimic biochemical composition, structural properties, and cellular morphology and diversity found in the native brain tissue. Crucial to these developments have been the advancements in stem cell technology and cell reprogramming protocols that allow reproducible generation of human subtype-specific neurons and glia in laboratory conditions. At the same time, biomaterials... (More)
Inherent limitations of the traditional approaches to study brain function and disease, such as rodent models and 2D cell culture platforms, have led to the development of 3D in vitro cell culture systems. These systems, products of multidisciplinary efforts encompassing stem cell biology, materials engineering, and biofabrication, have quickly shown great potential to mimic biochemical composition, structural properties, and cellular morphology and diversity found in the native brain tissue. Crucial to these developments have been the advancements in stem cell technology and cell reprogramming protocols that allow reproducible generation of human subtype-specific neurons and glia in laboratory conditions. At the same time, biomaterials have been designed to provide cells in 3D with a microenvironment that mimics functional and structural aspects of the native extracellular matrix with increasing fidelity. In this article, we review the use of biomaterials in 3D in vitro models of neurological disorders with focus on hydrogel technology and with biochemical composition and physical properties of the in vivo environment as reference.
(Less)
- author
- Kajtez, Janko
LU
; Nilsson, Fredrik
LU
; Fiorenzano, Alessandro
LU
; Parmar, Malin
LU
and Emnéus, Jenny
LU
- organization
- publishing date
- 2021
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Neurochemistry International
- volume
- 147
- article number
- 105043
- publisher
- Elsevier
- external identifiers
-
- pmid:33887378
- scopus:85106922797
- ISSN
- 0197-0186
- DOI
- 10.1016/j.neuint.2021.105043
- language
- English
- LU publication?
- yes
- id
- 4ee84827-c136-4f07-9d18-c329548f30bf
- date added to LUP
- 2021-05-05 09:46:07
- date last changed
- 2024-06-15 10:51:17
@article{4ee84827-c136-4f07-9d18-c329548f30bf,
abstract = {{<p>Inherent limitations of the traditional approaches to study brain function and disease, such as rodent models and 2D cell culture platforms, have led to the development of 3D in vitro cell culture systems. These systems, products of multidisciplinary efforts encompassing stem cell biology, materials engineering, and biofabrication, have quickly shown great potential to mimic biochemical composition, structural properties, and cellular morphology and diversity found in the native brain tissue. Crucial to these developments have been the advancements in stem cell technology and cell reprogramming protocols that allow reproducible generation of human subtype-specific neurons and glia in laboratory conditions. At the same time, biomaterials have been designed to provide cells in 3D with a microenvironment that mimics functional and structural aspects of the native extracellular matrix with increasing fidelity. In this article, we review the use of biomaterials in 3D in vitro models of neurological disorders with focus on hydrogel technology and with biochemical composition and physical properties of the in vivo environment as reference.</p>}},
author = {{Kajtez, Janko and Nilsson, Fredrik and Fiorenzano, Alessandro and Parmar, Malin and Emnéus, Jenny}},
issn = {{0197-0186}},
language = {{eng}},
publisher = {{Elsevier}},
series = {{Neurochemistry International}},
title = {{3D biomaterial models of human brain disease}},
url = {{http://dx.doi.org/10.1016/j.neuint.2021.105043}},
doi = {{10.1016/j.neuint.2021.105043}},
volume = {{147}},
year = {{2021}},
}