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The prognostic role of cancer stem cell markers for long-term outcome after resection of colonic liver metastases

Spelt, Lidewij LU ; Sasor, Agata; Ansari, Daniel LU ; Hilmersson, Katarzyna Said LU and Andersson, Roland LU (2018) In Anticancer Research 38(1). p.313-320
Abstract

Background/Aim: To assess the expression of cancer stem cell (CSC) markers CD44, CD133 and CD24 in colon cancer liver metastases and analyse their predictive value for overall survival (OS) and disease-free survival (DFS) after liver resection. Materials and Methods: Patients operated on for colon cancer liver metastases were included. CSC marker expression was determined through immunohistochemistry analysis. OS and DFS were compared between marker-positive and marker-negative patients. Multivariate analysis was performed to select predictive variables for OS and DFS. Results: CD133-positive patients had a worse DFS than CD133-negative patients, with a median DFS of 12 and 25 months (p=0.051). Multivariate analysis selected CD133... (More)

Background/Aim: To assess the expression of cancer stem cell (CSC) markers CD44, CD133 and CD24 in colon cancer liver metastases and analyse their predictive value for overall survival (OS) and disease-free survival (DFS) after liver resection. Materials and Methods: Patients operated on for colon cancer liver metastases were included. CSC marker expression was determined through immunohistochemistry analysis. OS and DFS were compared between marker-positive and marker-negative patients. Multivariate analysis was performed to select predictive variables for OS and DFS. Results: CD133-positive patients had a worse DFS than CD133-negative patients, with a median DFS of 12 and 25 months (p=0.051). Multivariate analysis selected CD133 expression as a significant predictor for DFS. CD44 and CD24 were not found to predict OS or DFS. Conclusion: CD133 expression in colonic liver metastases is a negative prognostic factor for DFS after liver resection. In the future, CD133 could be used as a biomarker for risk stratification, and possibly for developing novel targeted therapy.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Colonic neoplasms, Disease-free survival, Liver resection, Metastasis, Neoplastic stem cells, Survival analysis
in
Anticancer Research
volume
38
issue
1
pages
8 pages
publisher
International Institute of Cancer Research
external identifiers
  • scopus:85039776960
ISSN
0250-7005
DOI
10.21873/anticanres.12224
language
English
LU publication?
yes
id
4f3fad25-183c-426c-89a2-08f8c95b0f8d
date added to LUP
2018-01-24 13:47:53
date last changed
2018-01-24 13:47:53
@article{4f3fad25-183c-426c-89a2-08f8c95b0f8d,
  abstract     = {<p>Background/Aim: To assess the expression of cancer stem cell (CSC) markers CD44, CD133 and CD24 in colon cancer liver metastases and analyse their predictive value for overall survival (OS) and disease-free survival (DFS) after liver resection. Materials and Methods: Patients operated on for colon cancer liver metastases were included. CSC marker expression was determined through immunohistochemistry analysis. OS and DFS were compared between marker-positive and marker-negative patients. Multivariate analysis was performed to select predictive variables for OS and DFS. Results: CD133-positive patients had a worse DFS than CD133-negative patients, with a median DFS of 12 and 25 months (p=0.051). Multivariate analysis selected CD133 expression as a significant predictor for DFS. CD44 and CD24 were not found to predict OS or DFS. Conclusion: CD133 expression in colonic liver metastases is a negative prognostic factor for DFS after liver resection. In the future, CD133 could be used as a biomarker for risk stratification, and possibly for developing novel targeted therapy.</p>},
  author       = {Spelt, Lidewij and Sasor, Agata and Ansari, Daniel and Hilmersson, Katarzyna Said and Andersson, Roland},
  issn         = {0250-7005},
  keyword      = {Colonic neoplasms,Disease-free survival,Liver resection,Metastasis,Neoplastic stem cells,Survival analysis},
  language     = {eng},
  month        = {01},
  number       = {1},
  pages        = {313--320},
  publisher    = {International Institute of Cancer Research},
  series       = {Anticancer Research},
  title        = {The prognostic role of cancer stem cell markers for long-term outcome after resection of colonic liver metastases},
  url          = {http://dx.doi.org/10.21873/anticanres.12224},
  volume       = {38},
  year         = {2018},
}