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The Effect of Stopping Smoking on Disease Activity in Rheumatoid Arthritis (RA). Data from BARFOT, a Multicenter Study of Early RA

Andersson, Maria LE LU ; Bergman, Stefan LU and Söderlin, Maria K LU (2012) In Open Rheumatology Journal 6. p.303-309
Abstract

OBJECTIVE: We studied the effect of stopping smoking on disease activity in patients with RA.

METHODS: Between 1992 and 2005, 2,800 adult patients were included in the BARFOT early RA study in Sweden. Disease Activity Score 28 joints (DAS28), C-reactive protein (CRP), Health Assessment Questionnaire (HAQ), rheumatoid factor (RF), anti-CCP, general health and pain visual analog scales (VAS), EULAR response and treatment were registered at inclusion and at follow-up 2, 5 and 8 years. In 2010, a self-completion postal questionnaire was sent to 2,102 patients, enquiring about lifestyle factors, including cessation of smoking.

RESULTS: A total of 1,460 adult RA patients with disease duration ≤2 years were included in this study.... (More)

OBJECTIVE: We studied the effect of stopping smoking on disease activity in patients with RA.

METHODS: Between 1992 and 2005, 2,800 adult patients were included in the BARFOT early RA study in Sweden. Disease Activity Score 28 joints (DAS28), C-reactive protein (CRP), Health Assessment Questionnaire (HAQ), rheumatoid factor (RF), anti-CCP, general health and pain visual analog scales (VAS), EULAR response and treatment were registered at inclusion and at follow-up 2, 5 and 8 years. In 2010, a self-completion postal questionnaire was sent to 2,102 patients, enquiring about lifestyle factors, including cessation of smoking.

RESULTS: A total of 1,460 adult RA patients with disease duration ≤2 years were included in this study. Seventeen percent smoked in 2010. In total, 127 patients stopped smoking after inclusion in the study. Smoking cessation after inclusion in the study was negatively associated with EULAR good outcome at 8 years (OR 0.44, 95% CI 0.22-0.86, p=0.02), controlled for age, disease duration, sex, socioeconomic class, smoking status, RF, and DAS28 at inclusion.

CONCLUSION: Seventeen percent of the RA patients smoked in 2010 in this large Swedish RA cohort. Stopping smoking after onset of RA did not change the poor prognosis of smokers with RA, but all RA patients need to stop smoking because of the high risk of cardiovascular mortality and morbidity and the association of smoking with vasculitis and noduli in RA.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Open Rheumatology Journal
volume
6
pages
303 - 309
publisher
Bentham Open
external identifiers
  • scopus:84871029768
  • pmid:23115602
ISSN
1874-3129
DOI
10.2174/1874312901206010303
language
English
LU publication?
yes
id
4f622e8b-edfb-469a-80d8-904ac03f46ce
date added to LUP
2019-08-30 13:37:57
date last changed
2020-09-09 05:46:01
@article{4f622e8b-edfb-469a-80d8-904ac03f46ce,
  abstract     = {<p>OBJECTIVE: We studied the effect of stopping smoking on disease activity in patients with RA.</p><p>METHODS: Between 1992 and 2005, 2,800 adult patients were included in the BARFOT early RA study in Sweden. Disease Activity Score 28 joints (DAS28), C-reactive protein (CRP), Health Assessment Questionnaire (HAQ), rheumatoid factor (RF), anti-CCP, general health and pain visual analog scales (VAS), EULAR response and treatment were registered at inclusion and at follow-up 2, 5 and 8 years. In 2010, a self-completion postal questionnaire was sent to 2,102 patients, enquiring about lifestyle factors, including cessation of smoking.</p><p>RESULTS: A total of 1,460 adult RA patients with disease duration ≤2 years were included in this study. Seventeen percent smoked in 2010. In total, 127 patients stopped smoking after inclusion in the study. Smoking cessation after inclusion in the study was negatively associated with EULAR good outcome at 8 years (OR 0.44, 95% CI 0.22-0.86, p=0.02), controlled for age, disease duration, sex, socioeconomic class, smoking status, RF, and DAS28 at inclusion.</p><p>CONCLUSION: Seventeen percent of the RA patients smoked in 2010 in this large Swedish RA cohort. Stopping smoking after onset of RA did not change the poor prognosis of smokers with RA, but all RA patients need to stop smoking because of the high risk of cardiovascular mortality and morbidity and the association of smoking with vasculitis and noduli in RA.</p>},
  author       = {Andersson, Maria LE and Bergman, Stefan and Söderlin, Maria K},
  issn         = {1874-3129},
  language     = {eng},
  pages        = {303--309},
  publisher    = {Bentham Open},
  series       = {Open Rheumatology Journal},
  title        = {The Effect of Stopping Smoking on Disease Activity in Rheumatoid Arthritis (RA). Data from BARFOT, a Multicenter Study of Early RA},
  url          = {http://dx.doi.org/10.2174/1874312901206010303},
  doi          = {10.2174/1874312901206010303},
  volume       = {6},
  year         = {2012},
}