The Effect of Stopping Smoking on Disease Activity in Rheumatoid Arthritis (RA). Data from BARFOT, a Multicenter Study of Early RA
Andersson, Maria LE LU
; Bergman, Stefan
LU
and Söderlin, Maria K
LU
(2012)
In Open Rheumatology Journal
6.
p.303-309
- Abstract
OBJECTIVE: We studied the effect of stopping smoking on disease activity in patients with RA.
METHODS: Between 1992 and 2005, 2,800 adult patients were included in the BARFOT early RA study in Sweden. Disease Activity Score 28 joints (DAS28), C-reactive protein (CRP), Health Assessment Questionnaire (HAQ), rheumatoid factor (RF), anti-CCP, general health and pain visual analog scales (VAS), EULAR response and treatment were registered at inclusion and at follow-up 2, 5 and 8 years. In 2010, a self-completion postal questionnaire was sent to 2,102 patients, enquiring about lifestyle factors, including cessation of smoking.
RESULTS: A total of 1,460 adult RA patients with disease duration ≤2 years were included in this study.... (More)
OBJECTIVE: We studied the effect of stopping smoking on disease activity in patients with RA.
METHODS: Between 1992 and 2005, 2,800 adult patients were included in the BARFOT early RA study in Sweden. Disease Activity Score 28 joints (DAS28), C-reactive protein (CRP), Health Assessment Questionnaire (HAQ), rheumatoid factor (RF), anti-CCP, general health and pain visual analog scales (VAS), EULAR response and treatment were registered at inclusion and at follow-up 2, 5 and 8 years. In 2010, a self-completion postal questionnaire was sent to 2,102 patients, enquiring about lifestyle factors, including cessation of smoking.
RESULTS: A total of 1,460 adult RA patients with disease duration ≤2 years were included in this study. Seventeen percent smoked in 2010. In total, 127 patients stopped smoking after inclusion in the study. Smoking cessation after inclusion in the study was negatively associated with EULAR good outcome at 8 years (OR 0.44, 95% CI 0.22-0.86, p=0.02), controlled for age, disease duration, sex, socioeconomic class, smoking status, RF, and DAS28 at inclusion.
CONCLUSION: Seventeen percent of the RA patients smoked in 2010 in this large Swedish RA cohort. Stopping smoking after onset of RA did not change the poor prognosis of smokers with RA, but all RA patients need to stop smoking because of the high risk of cardiovascular mortality and morbidity and the association of smoking with vasculitis and noduli in RA.
(Less)
- author
- Andersson, Maria LE
LU
; Bergman, Stefan
LU
and Söderlin, Maria K
LU
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Open Rheumatology Journal
- volume
- 6
- pages
- 303 - 309
- publisher
- Bentham Open
- external identifiers
-
- pmid:23115602
- scopus:84871029768
- ISSN
- 1874-3129
- DOI
- 10.2174/1874312901206010303
- language
- English
- LU publication?
- yes
- id
- 4f622e8b-edfb-469a-80d8-904ac03f46ce
- date added to LUP
- 2019-08-30 13:37:57
- date last changed
- 2024-04-02 14:52:22
@article{4f622e8b-edfb-469a-80d8-904ac03f46ce,
abstract = {{<p>OBJECTIVE: We studied the effect of stopping smoking on disease activity in patients with RA.</p><p>METHODS: Between 1992 and 2005, 2,800 adult patients were included in the BARFOT early RA study in Sweden. Disease Activity Score 28 joints (DAS28), C-reactive protein (CRP), Health Assessment Questionnaire (HAQ), rheumatoid factor (RF), anti-CCP, general health and pain visual analog scales (VAS), EULAR response and treatment were registered at inclusion and at follow-up 2, 5 and 8 years. In 2010, a self-completion postal questionnaire was sent to 2,102 patients, enquiring about lifestyle factors, including cessation of smoking.</p><p>RESULTS: A total of 1,460 adult RA patients with disease duration ≤2 years were included in this study. Seventeen percent smoked in 2010. In total, 127 patients stopped smoking after inclusion in the study. Smoking cessation after inclusion in the study was negatively associated with EULAR good outcome at 8 years (OR 0.44, 95% CI 0.22-0.86, p=0.02), controlled for age, disease duration, sex, socioeconomic class, smoking status, RF, and DAS28 at inclusion.</p><p>CONCLUSION: Seventeen percent of the RA patients smoked in 2010 in this large Swedish RA cohort. Stopping smoking after onset of RA did not change the poor prognosis of smokers with RA, but all RA patients need to stop smoking because of the high risk of cardiovascular mortality and morbidity and the association of smoking with vasculitis and noduli in RA.</p>}},
author = {{Andersson, Maria LE and Bergman, Stefan and Söderlin, Maria K}},
issn = {{1874-3129}},
language = {{eng}},
pages = {{303--309}},
publisher = {{Bentham Open}},
series = {{Open Rheumatology Journal}},
title = {{The Effect of Stopping Smoking on Disease Activity in Rheumatoid Arthritis (RA). Data from BARFOT, a Multicenter Study of Early RA}},
url = {{http://dx.doi.org/10.2174/1874312901206010303}},
doi = {{10.2174/1874312901206010303}},
volume = {{6}},
year = {{2012}},
}