Endarterectomy patients with elevated levels of circulating IL-16 have fewer cardiovascular events during follow-up
Grönberg, Caitríona LU ; Asciutto, Giuseppe LU ; Persson, Ana LU ; Fredrikson, Gunilla Nordin LU ; Nilsson, Jan LU ; Gonçalves, Isabel LU
and Björkbacka, Harry
LU
(2016)
In Cytokine
85.
p.137-139
- Abstract
Background and purpose Increased interleukin 16 (IL-16) levels in carotid plaques have been associated with reduced incidence of cardiovascular (CV) events during follow-up in patients who underwent carotid endarterectomy (CEA). In the present study we aimed to determine whether high circulating levels of IL-16 also are associated with a decreased risk of CV events after CEA. Methods Patients, who had their carotid plaques surgically removed (n = 473), were followed for a mean follow-up time of 3.1 years. Plasma levels of IL-16 the day before surgery were analyzed by proximity extension assay (PEA) and associated with the occurrence of CV events during follow-up (n = 98). Results High levels of circulating IL-16 were independently... (More)
Background and purpose Increased interleukin 16 (IL-16) levels in carotid plaques have been associated with reduced incidence of cardiovascular (CV) events during follow-up in patients who underwent carotid endarterectomy (CEA). In the present study we aimed to determine whether high circulating levels of IL-16 also are associated with a decreased risk of CV events after CEA. Methods Patients, who had their carotid plaques surgically removed (n = 473), were followed for a mean follow-up time of 3.1 years. Plasma levels of IL-16 the day before surgery were analyzed by proximity extension assay (PEA) and associated with the occurrence of CV events during follow-up (n = 98). Results High levels of circulating IL-16 were independently associated with a decreased risk of CV events when comparing the highest versus the lowest IL-16 tertile (hazard ratio [HR] 0.47; 95% CI 0.27–0.81; P = 0.007), as well as with CV deaths (HR 0.25; 95% CI 0.09–0.70; P = 0.008). Conclusion These present findings indicate an association between IL-16 and less clinical complications of atherosclerosis in a population with known advanced carotid disease.
(Less)
- author
- Grönberg, Caitríona
LU
; Asciutto, Giuseppe
LU
; Persson, Ana
LU
; Fredrikson, Gunilla Nordin
LU
; Nilsson, Jan
LU
; Gonçalves, Isabel
LU
and Björkbacka, Harry
LU
- organization
- publishing date
- 2016-09
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Atherosclerosis, Cardiovascular events, Interleukin 16
- in
- Cytokine
- volume
- 85
- pages
- 3 pages
- publisher
- Academic Press
- external identifiers
-
- scopus:84976318101
- pmid:27344024
- wos:000380596000022
- ISSN
- 1043-4666
- DOI
- 10.1016/j.cyto.2016.06.009
- language
- English
- LU publication?
- yes
- id
- 4f66f1de-1eb3-4e8f-a25e-1df909c54545
- date added to LUP
- 2016-07-18 08:49:31
- date last changed
- 2025-01-12 08:58:59
@article{4f66f1de-1eb3-4e8f-a25e-1df909c54545,
abstract = {{<p>Background and purpose Increased interleukin 16 (IL-16) levels in carotid plaques have been associated with reduced incidence of cardiovascular (CV) events during follow-up in patients who underwent carotid endarterectomy (CEA). In the present study we aimed to determine whether high circulating levels of IL-16 also are associated with a decreased risk of CV events after CEA. Methods Patients, who had their carotid plaques surgically removed (n = 473), were followed for a mean follow-up time of 3.1 years. Plasma levels of IL-16 the day before surgery were analyzed by proximity extension assay (PEA) and associated with the occurrence of CV events during follow-up (n = 98). Results High levels of circulating IL-16 were independently associated with a decreased risk of CV events when comparing the highest versus the lowest IL-16 tertile (hazard ratio [HR] 0.47; 95% CI 0.27–0.81; P = 0.007), as well as with CV deaths (HR 0.25; 95% CI 0.09–0.70; P = 0.008). Conclusion These present findings indicate an association between IL-16 and less clinical complications of atherosclerosis in a population with known advanced carotid disease.</p>}},
author = {{Grönberg, Caitríona and Asciutto, Giuseppe and Persson, Ana and Fredrikson, Gunilla Nordin and Nilsson, Jan and Gonçalves, Isabel and Björkbacka, Harry}},
issn = {{1043-4666}},
keywords = {{Atherosclerosis; Cardiovascular events; Interleukin 16}},
language = {{eng}},
pages = {{137--139}},
publisher = {{Academic Press}},
series = {{Cytokine}},
title = {{Endarterectomy patients with elevated levels of circulating IL-16 have fewer cardiovascular events during follow-up}},
url = {{http://dx.doi.org/10.1016/j.cyto.2016.06.009}},
doi = {{10.1016/j.cyto.2016.06.009}},
volume = {{85}},
year = {{2016}},
}