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Quality of Life in a Swedish Cohort of Patients with Mycosis Fungoides

Hub, Daria ; Drott, Kristina LU ; Belfrage, Emma LU and Sonesson, Andreas LU (2026) In Acta Dermato-Venereologica 106.
Abstract

Mycosis fungoides (MF) is a disease that evolves slowly over years with few options for curative treatment. Improving health-related quality of life (HRQoL) is therefore an important treatment goal. This study aims to contribute to a better understanding of HRQoL, using a dermatology-adapted HRQoL questionnaire, Dermatology Life Quality Index (DLQI), in patients with MF. Baseline data from a cohort study (BIO-MUSE) of patients with MF wasere used to investigate which aspect of DLQI is the most affected and how DLQI relates to different clinical and physiological parameters. Data from a period of 12 months were used to study how DLQI changes over time. The symptom domain, for example itching, was the aspect of the DLQI that had the... (More)

Mycosis fungoides (MF) is a disease that evolves slowly over years with few options for curative treatment. Improving health-related quality of life (HRQoL) is therefore an important treatment goal. This study aims to contribute to a better understanding of HRQoL, using a dermatology-adapted HRQoL questionnaire, Dermatology Life Quality Index (DLQI), in patients with MF. Baseline data from a cohort study (BIO-MUSE) of patients with MF wasere used to investigate which aspect of DLQI is the most affected and how DLQI relates to different clinical and physiological parameters. Data from a period of 12 months were used to study how DLQI changes over time. The symptom domain, for example itching, was the aspect of the DLQI that had the greatest impact on HRQoL. Thymus and activation-regulated chemokine (TARC)/ chemokine (C-C) ligand 17 (CCL17) were analysed in blood and were shown to have a positive correlation with DLQI (r=0.482, p=0.043). It was further shown that increased itching at baseline was a strong predictor of a worse DLQI score in the domain of symptoms (r=0.677, p=0.002). Future research in a larger cohort is needed to investigate the effect of itch in HRQoLhealth-related quality of life in patients with MF.

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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Humans, Quality of Life, Mycosis Fungoides/psychology, Male, Female, Sweden, Middle Aged, Skin Neoplasms/psychology, Pruritus/psychology, Aged, Surveys and Questionnaires, Adult, Chemokine CCL17/blood, Time Factors, Severity of Illness Index
in
Acta Dermato-Venereologica
volume
106
article number
adv-2026-0364
publisher
Medical Journals Limited
external identifiers
  • pmid:42023497
  • scopus:105036607733
ISSN
1651-2057
DOI
10.2340/actadv.v106.adv-2026-0364
language
English
LU publication?
yes
id
4f68b556-8717-41f4-be3c-6d9bafcfc9ad
date added to LUP
2026-06-03 09:12:01
date last changed
2026-07-03 12:15:48
@article{4f68b556-8717-41f4-be3c-6d9bafcfc9ad,
  abstract     = {{<p>Mycosis fungoides (MF) is a disease that evolves slowly over years with few options for curative treatment. Improving health-related quality of life (HRQoL) is therefore an important treatment goal. This study aims to contribute to a better understanding of HRQoL, using a dermatology-adapted HRQoL questionnaire, Dermatology Life Quality Index (DLQI), in patients with MF. Baseline data from a cohort study (BIO-MUSE) of patients with MF wasere used to investigate which aspect of DLQI is the most affected and how DLQI relates to different clinical and physiological parameters. Data from a period of 12 months were used to study how DLQI changes over time. The symptom domain, for example itching, was the aspect of the DLQI that had the greatest impact on HRQoL. Thymus and activation-regulated chemokine (TARC)/ chemokine (C-C) ligand 17 (CCL17) were analysed in blood and were shown to have a positive correlation with DLQI (r=0.482, p=0.043). It was further shown that increased itching at baseline was a strong predictor of a worse DLQI score in the domain of symptoms (r=0.677, p=0.002). Future research in a larger cohort is needed to investigate the effect of itch in HRQoLhealth-related quality of life in patients with MF.</p>}},
  author       = {{Hub, Daria and Drott, Kristina and Belfrage, Emma and Sonesson, Andreas}},
  issn         = {{1651-2057}},
  keywords     = {{Humans; Quality of Life; Mycosis Fungoides/psychology; Male; Female; Sweden; Middle Aged; Skin Neoplasms/psychology; Pruritus/psychology; Aged; Surveys and Questionnaires; Adult; Chemokine CCL17/blood; Time Factors; Severity of Illness Index}},
  language     = {{eng}},
  month        = {{04}},
  publisher    = {{Medical Journals Limited}},
  series       = {{Acta Dermato-Venereologica}},
  title        = {{Quality of Life in a Swedish Cohort of Patients with Mycosis Fungoides}},
  url          = {{http://dx.doi.org/10.2340/actadv.v106.adv-2026-0364}},
  doi          = {{10.2340/actadv.v106.adv-2026-0364}},
  volume       = {{106}},
  year         = {{2026}},
}