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Factor VIII Products and Inhibitor Development in Severe Hemophilia A

Gouw, Samantha C. ; van der Bom, Johanna G. ; Ljung, Rolf LU orcid ; Escuriola, Carmen ; Cid, Ana R. ; Claeyssens-Donadel, Segolene ; van Geet, Christel ; Kenet, Gili ; Makipernaa, Anne and Molinari, Angelo Claudio , et al. (2013) In New England Journal of Medicine 368(3). p.231-239
Abstract
Background For previously untreated children with severe hemophilia A, it is unclear whether the type of factor VIII product administered and switching among products are associated with the development of clinically relevant inhibitory antibodies (inhibitor development). Methods We evaluated 574 consecutive patients with severe hemophilia A (factor VIII activity, <0.01 IU per milliliter) who were born between 2000 and 2010 and collected data on all clotting-factor administration for up to 75 exposure days. The primary outcome was inhibitor development, which was defined as at least two positive inhibitor tests with decreased in vivo recovery of factor VIII levels. Results Inhibitory antibodies developed in 177 of the 574 children... (More)
Background For previously untreated children with severe hemophilia A, it is unclear whether the type of factor VIII product administered and switching among products are associated with the development of clinically relevant inhibitory antibodies (inhibitor development). Methods We evaluated 574 consecutive patients with severe hemophilia A (factor VIII activity, <0.01 IU per milliliter) who were born between 2000 and 2010 and collected data on all clotting-factor administration for up to 75 exposure days. The primary outcome was inhibitor development, which was defined as at least two positive inhibitor tests with decreased in vivo recovery of factor VIII levels. Results Inhibitory antibodies developed in 177 of the 574 children (cumulative incidence, 32.4%); 116 patients had a high-titer inhibitory antibody, defined as a peak titer of at least 5 Bethesda units per milliliter (cumulative incidence, 22.4%). Plasma-derived products conferred a risk of inhibitor development that was similar to the risk with recombinant products (adjusted hazard ratio as compared with recombinant products, 0.96; 95% confidence interval [CI], 0.62 to 1.49). As compared with third-generation full-length recombinant products (derived from the full-length complementary DNA sequence of human factor VIII), second-generation full-length products were associated with an increased risk of inhibitor development (adjusted hazard ratio, 1.60; 95% CI, 1.08 to 2.37). The content of von Willebrand factor in the products and switching among products were not associated with the risk of inhibitor development. Conclusions Recombinant and plasma-derived factor VIII products conferred similar risks of inhibitor development, and the content of von Willebrand factor in the products and switching among products were not associated with the risk of inhibitor development. Second-generation full-length recombinant products were associated with an increased risk, as compared with third-generation products. (Funded by Bayer Healthcare and Baxter BioScience.) (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
New England Journal of Medicine
volume
368
issue
3
pages
231 - 239
publisher
Massachusetts Medical Society
external identifiers
  • wos:000313549900007
  • scopus:84872450786
  • pmid:23323899
ISSN
0028-4793
DOI
10.1056/NEJMoa1208024
language
English
LU publication?
yes
id
4f6caf6e-7397-4198-a7ad-47fee6806139 (old id 3470873)
date added to LUP
2016-04-01 10:00:47
date last changed
2022-04-27 17:17:56
@article{4f6caf6e-7397-4198-a7ad-47fee6806139,
  abstract     = {{Background For previously untreated children with severe hemophilia A, it is unclear whether the type of factor VIII product administered and switching among products are associated with the development of clinically relevant inhibitory antibodies (inhibitor development). Methods We evaluated 574 consecutive patients with severe hemophilia A (factor VIII activity, &lt;0.01 IU per milliliter) who were born between 2000 and 2010 and collected data on all clotting-factor administration for up to 75 exposure days. The primary outcome was inhibitor development, which was defined as at least two positive inhibitor tests with decreased in vivo recovery of factor VIII levels. Results Inhibitory antibodies developed in 177 of the 574 children (cumulative incidence, 32.4%); 116 patients had a high-titer inhibitory antibody, defined as a peak titer of at least 5 Bethesda units per milliliter (cumulative incidence, 22.4%). Plasma-derived products conferred a risk of inhibitor development that was similar to the risk with recombinant products (adjusted hazard ratio as compared with recombinant products, 0.96; 95% confidence interval [CI], 0.62 to 1.49). As compared with third-generation full-length recombinant products (derived from the full-length complementary DNA sequence of human factor VIII), second-generation full-length products were associated with an increased risk of inhibitor development (adjusted hazard ratio, 1.60; 95% CI, 1.08 to 2.37). The content of von Willebrand factor in the products and switching among products were not associated with the risk of inhibitor development. Conclusions Recombinant and plasma-derived factor VIII products conferred similar risks of inhibitor development, and the content of von Willebrand factor in the products and switching among products were not associated with the risk of inhibitor development. Second-generation full-length recombinant products were associated with an increased risk, as compared with third-generation products. (Funded by Bayer Healthcare and Baxter BioScience.)}},
  author       = {{Gouw, Samantha C. and van der Bom, Johanna G. and Ljung, Rolf and Escuriola, Carmen and Cid, Ana R. and Claeyssens-Donadel, Segolene and van Geet, Christel and Kenet, Gili and Makipernaa, Anne and Molinari, Angelo Claudio and Muntean, Wolfgang and Kobelt, Rainer and Rivard, George and Santagostino, Elena and Thomas, Angela and van den Berg, H. Marijke}},
  issn         = {{0028-4793}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{231--239}},
  publisher    = {{Massachusetts Medical Society}},
  series       = {{New England Journal of Medicine}},
  title        = {{Factor VIII Products and Inhibitor Development in Severe Hemophilia A}},
  url          = {{https://lup.lub.lu.se/search/files/1477598/3799624.pdf}},
  doi          = {{10.1056/NEJMoa1208024}},
  volume       = {{368}},
  year         = {{2013}},
}