Associations of Glycemic Control and Diabetes Duration With Dupuytren Disease in Men and Women With Type 1 and 2 Diabetes
Backman, Märta LU ; Nordenskjöld, Jesper LU ; Perez, Raquel LU
and Rydberg, Mattias
LU
(2026)
In Plastic and reconstructive surgery. Global open
14(1).
- Abstract
BACKGROUND: Dupuytren disease (DD) is a benign fibroproliferative disorder affecting the hand. Although diabetes mellitus is a known risk factor, the underlying mechanisms behind this association remain unclear. This study aimed to examine the relationship between glycemic control and DD in type 1 (T1D) and type 2 diabetes (T2D), and to identify other metabolic risk factors influencing DD risk.
METHODS: In this retrospective registry study, data from the Swedish National Diabetes Register and the Skåne Healthcare Register were cross-linked. In total, 96,039 individuals aged 18 years or older with T1D or T2D were included. Sex-stratified, multivariable logistic regression models calculated associations between HbA1c levels and DD... (More)
BACKGROUND: Dupuytren disease (DD) is a benign fibroproliferative disorder affecting the hand. Although diabetes mellitus is a known risk factor, the underlying mechanisms behind this association remain unclear. This study aimed to examine the relationship between glycemic control and DD in type 1 (T1D) and type 2 diabetes (T2D), and to identify other metabolic risk factors influencing DD risk.
METHODS: In this retrospective registry study, data from the Swedish National Diabetes Register and the Skåne Healthcare Register were cross-linked. In total, 96,039 individuals aged 18 years or older with T1D or T2D were included. Sex-stratified, multivariable logistic regression models calculated associations between HbA1c levels and DD risk. Interaction analyses evaluated whether diabetes duration modified the association between HbA1c levels and DD risk.
RESULTS: Longer diabetes duration consistently increased the risk of DD in both T1D and T2D groups. A trend toward increased DD risk with higher HbA1c levels was seen in T1D (P > 0.05). Higher body mass index was inversely associated with DD in men and women with T2D (P < 0.05). No interaction was observed between HbA1c levels and diabetes duration.
CONCLUSIONS: Diabetes duration seems to be a strong and independent risk factor for DD in T1D and T2D. Although a trend toward higher DD risk with elevated HbA1c was observed in T1D, no interaction with diabetes duration was found. A higher body mass index was associated with a lower risk of DD in individuals with T2D.
(Less)
- author
- Backman, Märta
LU
; Nordenskjöld, Jesper
LU
; Perez, Raquel
LU
and Rydberg, Mattias
LU
- organization
- publishing date
- 2026-01
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Plastic and reconstructive surgery. Global open
- volume
- 14
- issue
- 1
- article number
- e7435
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- pmid:41614044
- ISSN
- 2169-7574
- DOI
- 10.1097/GOX.0000000000007435
- language
- English
- LU publication?
- yes
- additional info
- Copyright © 2026 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of The American Society of Plastic Surgeons.
- id
- 4febdcf4-e17f-446d-912c-569258b7d6ba
- date added to LUP
- 2026-02-02 13:47:47
- date last changed
- 2026-02-02 14:43:11
@article{4febdcf4-e17f-446d-912c-569258b7d6ba,
abstract = {{<p>BACKGROUND: Dupuytren disease (DD) is a benign fibroproliferative disorder affecting the hand. Although diabetes mellitus is a known risk factor, the underlying mechanisms behind this association remain unclear. This study aimed to examine the relationship between glycemic control and DD in type 1 (T1D) and type 2 diabetes (T2D), and to identify other metabolic risk factors influencing DD risk.</p><p>METHODS: In this retrospective registry study, data from the Swedish National Diabetes Register and the Skåne Healthcare Register were cross-linked. In total, 96,039 individuals aged 18 years or older with T1D or T2D were included. Sex-stratified, multivariable logistic regression models calculated associations between HbA1c levels and DD risk. Interaction analyses evaluated whether diabetes duration modified the association between HbA1c levels and DD risk.</p><p>RESULTS: Longer diabetes duration consistently increased the risk of DD in both T1D and T2D groups. A trend toward increased DD risk with higher HbA1c levels was seen in T1D (P > 0.05). Higher body mass index was inversely associated with DD in men and women with T2D (P < 0.05). No interaction was observed between HbA1c levels and diabetes duration.</p><p>CONCLUSIONS: Diabetes duration seems to be a strong and independent risk factor for DD in T1D and T2D. Although a trend toward higher DD risk with elevated HbA1c was observed in T1D, no interaction with diabetes duration was found. A higher body mass index was associated with a lower risk of DD in individuals with T2D.</p>}},
author = {{Backman, Märta and Nordenskjöld, Jesper and Perez, Raquel and Rydberg, Mattias}},
issn = {{2169-7574}},
language = {{eng}},
number = {{1}},
publisher = {{Lippincott Williams & Wilkins}},
series = {{Plastic and reconstructive surgery. Global open}},
title = {{Associations of Glycemic Control and Diabetes Duration With Dupuytren Disease in Men and Women With Type 1 and 2 Diabetes}},
url = {{http://dx.doi.org/10.1097/GOX.0000000000007435}},
doi = {{10.1097/GOX.0000000000007435}},
volume = {{14}},
year = {{2026}},
}