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Classification of osteoarthritis biomarkers: a proposed approach

Bauer, D. C. ; Hunter, D. J. ; Abramson, S. B. ; Attur, M. ; Corr, M. ; Felson, D. ; Heinegård, Dick LU ; Jordan, J. M. ; Kepler, T. B. and Lane, N. E. , et al. (2006) In Osteoarthritis and Cartilage 14(8). p.723-727
Abstract
Objective: Osteoarthritis (OA) biomarkers are needed by researchers and clinicians to assist in disease diagnosis and assessment of disease severity, risk of onset, and progression. As effective agents for CA are developed and tested in clinical studies, biomarkers; that reliably mirror or predict the progression or amelioration of CA will also be needed. Methods: The NIH-funded CA Biomarkers Network is a multidisciplinary group interested in the development and validation of CA biomarkers. This review summarizes our efforts to characterize and classify CA biomarkers. Results: We propose the "BIPED" biomarker classification (which stands for Burden of Disease, Investigative, Prognostic, Efficacy of Intervention and Diagnostic), and offer... (More)
Objective: Osteoarthritis (OA) biomarkers are needed by researchers and clinicians to assist in disease diagnosis and assessment of disease severity, risk of onset, and progression. As effective agents for CA are developed and tested in clinical studies, biomarkers; that reliably mirror or predict the progression or amelioration of CA will also be needed. Methods: The NIH-funded CA Biomarkers Network is a multidisciplinary group interested in the development and validation of CA biomarkers. This review summarizes our efforts to characterize and classify CA biomarkers. Results: We propose the "BIPED" biomarker classification (which stands for Burden of Disease, Investigative, Prognostic, Efficacy of Intervention and Diagnostic), and offer suggestions on optimal study design and analytic methods for use in CA investigations. Conclusion. The BIPED classification provides specific biomarker definitions with the goal of improving our ability to develop and analyze OA biomarkers, and to communicate these advances within a common framework. (C) 2006 OsteoArthritis Research Society International. Published by Elsevier Ltd. All rights reserved. (Less)
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publication status
published
subject
keywords
osteoarthritis, biomarkers, study design
in
Osteoarthritis and Cartilage
volume
14
issue
8
pages
723 - 727
publisher
Elsevier
external identifiers
  • wos:000239386900001
  • scopus:33745615815
ISSN
1063-4584
DOI
10.1016/j.joca.2006.04.001
language
English
LU publication?
yes
id
502202d7-a36d-4b74-ad0c-a335bbe1c735 (old id 399365)
date added to LUP
2016-04-01 12:25:22
date last changed
2020-01-15 02:44:08
@article{502202d7-a36d-4b74-ad0c-a335bbe1c735,
  abstract     = {Objective: Osteoarthritis (OA) biomarkers are needed by researchers and clinicians to assist in disease diagnosis and assessment of disease severity, risk of onset, and progression. As effective agents for CA are developed and tested in clinical studies, biomarkers; that reliably mirror or predict the progression or amelioration of CA will also be needed. Methods: The NIH-funded CA Biomarkers Network is a multidisciplinary group interested in the development and validation of CA biomarkers. This review summarizes our efforts to characterize and classify CA biomarkers. Results: We propose the "BIPED" biomarker classification (which stands for Burden of Disease, Investigative, Prognostic, Efficacy of Intervention and Diagnostic), and offer suggestions on optimal study design and analytic methods for use in CA investigations. Conclusion. The BIPED classification provides specific biomarker definitions with the goal of improving our ability to develop and analyze OA biomarkers, and to communicate these advances within a common framework. (C) 2006 OsteoArthritis Research Society International. Published by Elsevier Ltd. All rights reserved.},
  author       = {Bauer, D. C. and Hunter, D. J. and Abramson, S. B. and Attur, M. and Corr, M. and Felson, D. and Heinegård, Dick and Jordan, J. M. and Kepler, T. B. and Lane, N. E. and Saxne, Tore and Tyree, B. and Kraus, V. B.},
  issn         = {1063-4584},
  language     = {eng},
  number       = {8},
  pages        = {723--727},
  publisher    = {Elsevier},
  series       = {Osteoarthritis and Cartilage},
  title        = {Classification of osteoarthritis biomarkers: a proposed approach},
  url          = {http://dx.doi.org/10.1016/j.joca.2006.04.001},
  doi          = {10.1016/j.joca.2006.04.001},
  volume       = {14},
  year         = {2006},
}