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A review of the biology of calcium phosphate sequestration with special reference to milk.

Lenton, Samuel; Nylander, Tommy LU ; Teixeira, Susana C M and Holt, Carl (2015) In Dairy Science & Technology 95(1). p.3-14
Abstract
In milk, a stable fluid is formed in which sequestered nanoclusters of calcium phosphate are substructures in casein micelles. As a result, calcium and phosphate concentrations in milk can be far in excess of their solubility. Variations of calcium, phosphate and casein concentrations in milks, both within and among species, are mainly due to the formation of the nanocluster complexes. Caseins evolved from tooth and bone proteins well before the evolution of lactation. It has therefore been suggested that the role of caseins in milk is an adaptation of an antecedent function in the control of some aspect of biomineralisation. There is new evidence that nanocluster-type complexes are also present in blood serum and, by implication, in many... (More)
In milk, a stable fluid is formed in which sequestered nanoclusters of calcium phosphate are substructures in casein micelles. As a result, calcium and phosphate concentrations in milk can be far in excess of their solubility. Variations of calcium, phosphate and casein concentrations in milks, both within and among species, are mainly due to the formation of the nanocluster complexes. Caseins evolved from tooth and bone proteins well before the evolution of lactation. It has therefore been suggested that the role of caseins in milk is an adaptation of an antecedent function in the control of some aspect of biomineralisation. There is new evidence that nanocluster-type complexes are also present in blood serum and, by implication, in many other closely related biofluids. Because such fluids are stable but nevertheless supersaturated with respect to the bone and tooth mineral hydroxyapatite, they allow soft and mineralised tissues to co-exist in the same organism with relative ease. An appreciable concentration of nanocluster complexes exists in fresh saliva. Such saliva may stabilise tooth mineral and help to repair demineralised lesions. In the extracellular matrix of bone, nanocluster complexes may be involved in directing the amorphous calcium phosphate to intrafibrillar spaces in collagen where they can mature into oriented apatite crystals. Thus, evidence is accumulating that calcium phosphate sequestration by phosphopeptides to form equilibrium complexes, first observed in milk, is more generally important in the control of physiological calcification. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Dairy Science & Technology
volume
95
issue
1
pages
3 - 14
publisher
Springer
external identifiers
  • pmid:25632319
  • wos:000348340400002
  • scopus:84921932504
ISSN
1958-5586
DOI
10.1007/s13594-014-0177-2
language
English
LU publication?
yes
id
d85543d8-2529-46e2-8a5f-807965deaf81 (old id 5039072)
date added to LUP
2015-02-10 19:31:26
date last changed
2017-10-22 04:19:36
@article{d85543d8-2529-46e2-8a5f-807965deaf81,
  abstract     = {In milk, a stable fluid is formed in which sequestered nanoclusters of calcium phosphate are substructures in casein micelles. As a result, calcium and phosphate concentrations in milk can be far in excess of their solubility. Variations of calcium, phosphate and casein concentrations in milks, both within and among species, are mainly due to the formation of the nanocluster complexes. Caseins evolved from tooth and bone proteins well before the evolution of lactation. It has therefore been suggested that the role of caseins in milk is an adaptation of an antecedent function in the control of some aspect of biomineralisation. There is new evidence that nanocluster-type complexes are also present in blood serum and, by implication, in many other closely related biofluids. Because such fluids are stable but nevertheless supersaturated with respect to the bone and tooth mineral hydroxyapatite, they allow soft and mineralised tissues to co-exist in the same organism with relative ease. An appreciable concentration of nanocluster complexes exists in fresh saliva. Such saliva may stabilise tooth mineral and help to repair demineralised lesions. In the extracellular matrix of bone, nanocluster complexes may be involved in directing the amorphous calcium phosphate to intrafibrillar spaces in collagen where they can mature into oriented apatite crystals. Thus, evidence is accumulating that calcium phosphate sequestration by phosphopeptides to form equilibrium complexes, first observed in milk, is more generally important in the control of physiological calcification.},
  author       = {Lenton, Samuel and Nylander, Tommy and Teixeira, Susana C M and Holt, Carl},
  issn         = {1958-5586},
  language     = {eng},
  number       = {1},
  pages        = {3--14},
  publisher    = {Springer},
  series       = {Dairy Science & Technology},
  title        = {A review of the biology of calcium phosphate sequestration with special reference to milk.},
  url          = {http://dx.doi.org/10.1007/s13594-014-0177-2},
  volume       = {95},
  year         = {2015},
}