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Myeloid-related protein 14 promote inflammation and injury in meningitis.

Wache, Christina; Klein, Matthias; Ostergaard, Christian; Angele, Barbara; Häcker, Hans; Pfister, Hans-Walter; Pruenster, Monika; Sperandio, Markus; Leanderson, Tomas LU and Roth, Johannes, et al. (2015) In Journal of Infectious Diseases 212(2). p.247-257
Abstract
Neutrophilic inflammation often persists over days despite efficient antibiotic treatment and contributes to brain damage in bacterial meningitis. We proposed here that MRP14, an abundant cytosolic protein in myeloid cells, acts as an endogenous danger signal, driving inflammation and aggravating tissue injury.
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Contribution to journal
publication status
published
subject
in
Journal of Infectious Diseases
volume
212
issue
2
pages
247 - 257
publisher
Oxford University Press
external identifiers
  • pmid:25605866
  • wos:000357823300010
  • scopus:84936867554
ISSN
1537-6613
DOI
10.1093/infdis/jiv028
language
English
LU publication?
yes
id
bb5ca0c7-3186-4c7a-b19e-4ef194dc5c8e (old id 5040077)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25605866?dopt=Abstract
date added to LUP
2015-02-03 20:09:07
date last changed
2017-11-12 03:02:32
@article{bb5ca0c7-3186-4c7a-b19e-4ef194dc5c8e,
  abstract     = {Neutrophilic inflammation often persists over days despite efficient antibiotic treatment and contributes to brain damage in bacterial meningitis. We proposed here that MRP14, an abundant cytosolic protein in myeloid cells, acts as an endogenous danger signal, driving inflammation and aggravating tissue injury.},
  author       = {Wache, Christina and Klein, Matthias and Ostergaard, Christian and Angele, Barbara and Häcker, Hans and Pfister, Hans-Walter and Pruenster, Monika and Sperandio, Markus and Leanderson, Tomas and Roth, Johannes and Vogl, Thomas and Koedel, Uwe},
  issn         = {1537-6613},
  language     = {eng},
  number       = {2},
  pages        = {247--257},
  publisher    = {Oxford University Press},
  series       = {Journal of Infectious Diseases},
  title        = {Myeloid-related protein 14 promote inflammation and injury in meningitis.},
  url          = {http://dx.doi.org/10.1093/infdis/jiv028},
  volume       = {212},
  year         = {2015},
}