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Syndecan-4 is a key determinant of collagen cross-linking and passive myocardial stiffness in the pressure-overloaded heart.

Herum Möller, Kate LU ; Lunde, Ida G; Skrbic, Biljana; Louch, William E; Hasic, Almira; Boye, Sigurd; Unger, Andreas; Brorson, Sverre-Henning; Sjaastad, Ivar and Tønnessen, Theis, et al. (2015) In Cardiovascular Research 106(2). p.217-226
Abstract
Diastolic dysfunction is central to the development of heart failure. To date, there is no effective treatment and only limited understanding of its molecular basis. Recently, we showed that the transmembrane proteoglycan syndecan-4 increases in the left ventricle after pressure overload in mice and man, and that syndecan-4 via calcineurin/nuclear factor of activated T-cells (NFAT) promotes myofibroblast differentiation and collagen production upon mechanical stress. The aim of this study was to investigate whether syndecan-4 affects collagen cross-linking and myocardial stiffening in the pressure-overloaded heart.
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type
Contribution to journal
publication status
published
subject
in
Cardiovascular Research
volume
106
issue
2
pages
217 - 226
publisher
Elsevier
external identifiers
  • pmid:25587045
  • wos:000356182900008
  • scopus:84929087023
ISSN
1755-3245
DOI
10.1093/cvr/cvv002
language
English
LU publication?
yes
id
814203e1-7f20-46ad-ba1a-a3d28d78c834 (old id 5040398)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25587045?dopt=Abstract
date added to LUP
2015-02-03 17:24:39
date last changed
2017-10-29 03:20:11
@article{814203e1-7f20-46ad-ba1a-a3d28d78c834,
  abstract     = {Diastolic dysfunction is central to the development of heart failure. To date, there is no effective treatment and only limited understanding of its molecular basis. Recently, we showed that the transmembrane proteoglycan syndecan-4 increases in the left ventricle after pressure overload in mice and man, and that syndecan-4 via calcineurin/nuclear factor of activated T-cells (NFAT) promotes myofibroblast differentiation and collagen production upon mechanical stress. The aim of this study was to investigate whether syndecan-4 affects collagen cross-linking and myocardial stiffening in the pressure-overloaded heart.},
  author       = {Herum Möller, Kate and Lunde, Ida G and Skrbic, Biljana and Louch, William E and Hasic, Almira and Boye, Sigurd and Unger, Andreas and Brorson, Sverre-Henning and Sjaastad, Ivar and Tønnessen, Theis and Linke, Wolfgang A and Gomez, Maria and Christensen, Geir},
  issn         = {1755-3245},
  language     = {eng},
  number       = {2},
  pages        = {217--226},
  publisher    = {Elsevier},
  series       = {Cardiovascular Research},
  title        = {Syndecan-4 is a key determinant of collagen cross-linking and passive myocardial stiffness in the pressure-overloaded heart.},
  url          = {http://dx.doi.org/10.1093/cvr/cvv002},
  volume       = {106},
  year         = {2015},
}