Syndecan-4 is a key determinant of collagen cross-linking and passive myocardial stiffness in the pressure-overloaded heart.
(2015) In Cardiovascular Research 106(2). p.217-226- Abstract
- Diastolic dysfunction is central to the development of heart failure. To date, there is no effective treatment and only limited understanding of its molecular basis. Recently, we showed that the transmembrane proteoglycan syndecan-4 increases in the left ventricle after pressure overload in mice and man, and that syndecan-4 via calcineurin/nuclear factor of activated T-cells (NFAT) promotes myofibroblast differentiation and collagen production upon mechanical stress. The aim of this study was to investigate whether syndecan-4 affects collagen cross-linking and myocardial stiffening in the pressure-overloaded heart.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/5040398
- author
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Cardiovascular Research
- volume
- 106
- issue
- 2
- pages
- 217 - 226
- publisher
- Oxford University Press
- external identifiers
-
- pmid:25587045
- wos:000356182900008
- scopus:84929087023
- pmid:25587045
- ISSN
- 1755-3245
- DOI
- 10.1093/cvr/cvv002
- language
- English
- LU publication?
- yes
- id
- 814203e1-7f20-46ad-ba1a-a3d28d78c834 (old id 5040398)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/25587045?dopt=Abstract
- date added to LUP
- 2016-04-01 11:02:11
- date last changed
- 2022-04-12 19:53:41
@article{814203e1-7f20-46ad-ba1a-a3d28d78c834, abstract = {{Diastolic dysfunction is central to the development of heart failure. To date, there is no effective treatment and only limited understanding of its molecular basis. Recently, we showed that the transmembrane proteoglycan syndecan-4 increases in the left ventricle after pressure overload in mice and man, and that syndecan-4 via calcineurin/nuclear factor of activated T-cells (NFAT) promotes myofibroblast differentiation and collagen production upon mechanical stress. The aim of this study was to investigate whether syndecan-4 affects collagen cross-linking and myocardial stiffening in the pressure-overloaded heart.}}, author = {{Herum Möller, Kate and Lunde, Ida G and Skrbic, Biljana and Louch, William E and Hasic, Almira and Boye, Sigurd and Unger, Andreas and Brorson, Sverre-Henning and Sjaastad, Ivar and Tønnessen, Theis and Linke, Wolfgang A and Gomez, Maria and Christensen, Geir}}, issn = {{1755-3245}}, language = {{eng}}, number = {{2}}, pages = {{217--226}}, publisher = {{Oxford University Press}}, series = {{Cardiovascular Research}}, title = {{Syndecan-4 is a key determinant of collagen cross-linking and passive myocardial stiffness in the pressure-overloaded heart.}}, url = {{http://dx.doi.org/10.1093/cvr/cvv002}}, doi = {{10.1093/cvr/cvv002}}, volume = {{106}}, year = {{2015}}, }