Multifaceted role of the ubiquitin ligase Itch in immune regulation.
(2015) In Immunology and Cell Biology 93(5). p.452-460- Abstract
- The HECT-type E3 ligase Itch is increasingly being shown to have a vital role in immune regulation. Itch deficiency leads to deleterious inflammatory disorders both in mice and humans. By adding ubiquitin to the key signaling intermediates, Itch functions as a critical regulator of lymphocyte-cell activation, differentiation and immune tolerance. Also, Itch cooperates with deubiquitinating enzymes such as A20 and Cyld to terminate NF-κB signaling and prevent chronic inflammation. This review summarizes recent advances that highlight Itch's role in lymphocyte function and explores recent insights regarding its role as a regulator of inflammatory signaling.Immunology and Cell Biology advance online publication, 13 January 2015;... (More)
- The HECT-type E3 ligase Itch is increasingly being shown to have a vital role in immune regulation. Itch deficiency leads to deleterious inflammatory disorders both in mice and humans. By adding ubiquitin to the key signaling intermediates, Itch functions as a critical regulator of lymphocyte-cell activation, differentiation and immune tolerance. Also, Itch cooperates with deubiquitinating enzymes such as A20 and Cyld to terminate NF-κB signaling and prevent chronic inflammation. This review summarizes recent advances that highlight Itch's role in lymphocyte function and explores recent insights regarding its role as a regulator of inflammatory signaling.Immunology and Cell Biology advance online publication, 13 January 2015; doi:10.1038/icb.2014.118. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/5040488
- author
- Venuprasad, K ; Zeng, Minghui ; Baughan, Scott L and Massoumi, Ramin LU
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Immunology and Cell Biology
- volume
- 93
- issue
- 5
- pages
- 452 - 460
- publisher
- Nature Publishing Group
- external identifiers
-
- pmid:25582340
- wos:000355190100007
- scopus:84929961711
- pmid:25582340
- ISSN
- 1440-1711
- DOI
- 10.1038/icb.2014.118
- language
- English
- LU publication?
- yes
- id
- 9f0b33ce-bae8-4d7b-995f-73d0ca36c25e (old id 5040488)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/25582340?dopt=Abstract
- date added to LUP
- 2016-04-01 10:37:39
- date last changed
- 2022-04-04 19:54:18
@article{9f0b33ce-bae8-4d7b-995f-73d0ca36c25e, abstract = {{The HECT-type E3 ligase Itch is increasingly being shown to have a vital role in immune regulation. Itch deficiency leads to deleterious inflammatory disorders both in mice and humans. By adding ubiquitin to the key signaling intermediates, Itch functions as a critical regulator of lymphocyte-cell activation, differentiation and immune tolerance. Also, Itch cooperates with deubiquitinating enzymes such as A20 and Cyld to terminate NF-κB signaling and prevent chronic inflammation. This review summarizes recent advances that highlight Itch's role in lymphocyte function and explores recent insights regarding its role as a regulator of inflammatory signaling.Immunology and Cell Biology advance online publication, 13 January 2015; doi:10.1038/icb.2014.118.}}, author = {{Venuprasad, K and Zeng, Minghui and Baughan, Scott L and Massoumi, Ramin}}, issn = {{1440-1711}}, language = {{eng}}, number = {{5}}, pages = {{452--460}}, publisher = {{Nature Publishing Group}}, series = {{Immunology and Cell Biology}}, title = {{Multifaceted role of the ubiquitin ligase Itch in immune regulation.}}, url = {{http://dx.doi.org/10.1038/icb.2014.118}}, doi = {{10.1038/icb.2014.118}}, volume = {{93}}, year = {{2015}}, }