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Multifaceted role of the ubiquitin ligase Itch in immune regulation.

Venuprasad, K; Zeng, Minghui; Baughan, Scott L and Massoumi, Ramin LU (2015) In Immunology and Cell Biology 93(5). p.452-460
Abstract
The HECT-type E3 ligase Itch is increasingly being shown to have a vital role in immune regulation. Itch deficiency leads to deleterious inflammatory disorders both in mice and humans. By adding ubiquitin to the key signaling intermediates, Itch functions as a critical regulator of lymphocyte-cell activation, differentiation and immune tolerance. Also, Itch cooperates with deubiquitinating enzymes such as A20 and Cyld to terminate NF-κB signaling and prevent chronic inflammation. This review summarizes recent advances that highlight Itch's role in lymphocyte function and explores recent insights regarding its role as a regulator of inflammatory signaling.Immunology and Cell Biology advance online publication, 13 January 2015;... (More)
The HECT-type E3 ligase Itch is increasingly being shown to have a vital role in immune regulation. Itch deficiency leads to deleterious inflammatory disorders both in mice and humans. By adding ubiquitin to the key signaling intermediates, Itch functions as a critical regulator of lymphocyte-cell activation, differentiation and immune tolerance. Also, Itch cooperates with deubiquitinating enzymes such as A20 and Cyld to terminate NF-κB signaling and prevent chronic inflammation. This review summarizes recent advances that highlight Itch's role in lymphocyte function and explores recent insights regarding its role as a regulator of inflammatory signaling.Immunology and Cell Biology advance online publication, 13 January 2015; doi:10.1038/icb.2014.118. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Immunology and Cell Biology
volume
93
issue
5
pages
452 - 460
publisher
Nature Publishing Group
external identifiers
  • pmid:25582340
  • wos:000355190100007
  • scopus:84929961711
ISSN
1440-1711
DOI
10.1038/icb.2014.118
language
English
LU publication?
yes
id
9f0b33ce-bae8-4d7b-995f-73d0ca36c25e (old id 5040488)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25582340?dopt=Abstract
date added to LUP
2015-02-03 16:59:30
date last changed
2017-07-23 03:19:45
@article{9f0b33ce-bae8-4d7b-995f-73d0ca36c25e,
  abstract     = {The HECT-type E3 ligase Itch is increasingly being shown to have a vital role in immune regulation. Itch deficiency leads to deleterious inflammatory disorders both in mice and humans. By adding ubiquitin to the key signaling intermediates, Itch functions as a critical regulator of lymphocyte-cell activation, differentiation and immune tolerance. Also, Itch cooperates with deubiquitinating enzymes such as A20 and Cyld to terminate NF-κB signaling and prevent chronic inflammation. This review summarizes recent advances that highlight Itch's role in lymphocyte function and explores recent insights regarding its role as a regulator of inflammatory signaling.Immunology and Cell Biology advance online publication, 13 January 2015; doi:10.1038/icb.2014.118.},
  author       = {Venuprasad, K and Zeng, Minghui and Baughan, Scott L and Massoumi, Ramin},
  issn         = {1440-1711},
  language     = {eng},
  number       = {5},
  pages        = {452--460},
  publisher    = {Nature Publishing Group},
  series       = {Immunology and Cell Biology},
  title        = {Multifaceted role of the ubiquitin ligase Itch in immune regulation.},
  url          = {http://dx.doi.org/10.1038/icb.2014.118},
  volume       = {93},
  year         = {2015},
}