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Radiolabeled antibodies in prostate cancer: A case study showing the effect of host immunity on antibody bio-distribution.

Vilhelmsson Timmermand, Oskar LU ; Santos, Elmer; Thorek, Daniel L J; Evans Axelsson, Susan LU ; Bjartell, Anders LU ; Lilja, Hans LU ; Larson, Steven M; Strand, Sven-Erik LU ; Tran, Thuy LU and Ulmert, David LU (2015) In Nuclear Medicine and Biology 42(4). p.375-380
Abstract
Human tumors xenografted in immunodeficient mice are crucial models in nuclear medicine to evaluate the effectiveness of candidate diagnostic and therapeutic compounds. However, little attention has been focused on the biological profile of the host model and its potential effects on the bio-distribution and tumor targeting of the tracer compound under study. We specifically investigated the dissimilarity in bio-distribution of (111)In-DTPA-5A10, which targets free prostate specific antigen (fPSA), in two animal models.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Nuclear Medicine and Biology
volume
42
issue
4
pages
375 - 380
publisher
Elsevier
external identifiers
  • pmid:25577038
  • wos:000352182300007
  • scopus:84924853675
ISSN
1872-9614
DOI
10.1016/j.nucmedbio.2014.12.012
language
English
LU publication?
yes
id
7d77cedd-f71c-42a5-a847-29a01bbc09bf (old id 5040843)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25577038?dopt=Abstract
date added to LUP
2015-02-05 17:36:48
date last changed
2017-10-08 03:10:31
@article{7d77cedd-f71c-42a5-a847-29a01bbc09bf,
  abstract     = {Human tumors xenografted in immunodeficient mice are crucial models in nuclear medicine to evaluate the effectiveness of candidate diagnostic and therapeutic compounds. However, little attention has been focused on the biological profile of the host model and its potential effects on the bio-distribution and tumor targeting of the tracer compound under study. We specifically investigated the dissimilarity in bio-distribution of (111)In-DTPA-5A10, which targets free prostate specific antigen (fPSA), in two animal models.},
  author       = {Vilhelmsson Timmermand, Oskar and Santos, Elmer and Thorek, Daniel L J and Evans Axelsson, Susan and Bjartell, Anders and Lilja, Hans and Larson, Steven M and Strand, Sven-Erik and Tran, Thuy and Ulmert, David},
  issn         = {1872-9614},
  language     = {eng},
  number       = {4},
  pages        = {375--380},
  publisher    = {Elsevier},
  series       = {Nuclear Medicine and Biology},
  title        = {Radiolabeled antibodies in prostate cancer: A case study showing the effect of host immunity on antibody bio-distribution.},
  url          = {http://dx.doi.org/10.1016/j.nucmedbio.2014.12.012},
  volume       = {42},
  year         = {2015},
}