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Pituitary adenylate cyclase activating polypeptide and migraine.

Zagami, Alessandro S; Edvinsson, Lars LU and Goadsby, Peter J (2014) In Annals of Clinical and Translational Neurology 1(12). p.1036-1040
Abstract
Pituitary adenylate cyclase activating peptide (PACAP) is found in human trigeminocervical complex and can trigger migraine. PACAP levels were measured using a sensitive radioimmunoassay. Stimulation of the superior sagittal sinus (SSS) in cat elevated PACAP levels in cranial blood. Patients with moderate or severe migraine headache had elevated PACAP in the external jugular vein during headache (n = 15), that was reduced 1 h after treatment with sumatriptan 6 mg (n = 11), and further reduced interictally (n = 9). The data suggest PACAP, or its receptors, are a promising target for migraine therapeutics.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Annals of Clinical and Translational Neurology
volume
1
issue
12
pages
1036 - 1040
publisher
Wiley-Blackwell
external identifiers
  • pmid:25574477
ISSN
2328-9503
DOI
10.1002/acn3.113
language
English
LU publication?
yes
id
1632c028-2dbf-4da7-b8b3-8fd1bc9d3c43 (old id 5040891)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25574477?dopt=Abstract
date added to LUP
2015-02-05 17:26:58
date last changed
2016-09-20 04:12:41
@article{1632c028-2dbf-4da7-b8b3-8fd1bc9d3c43,
  abstract     = {Pituitary adenylate cyclase activating peptide (PACAP) is found in human trigeminocervical complex and can trigger migraine. PACAP levels were measured using a sensitive radioimmunoassay. Stimulation of the superior sagittal sinus (SSS) in cat elevated PACAP levels in cranial blood. Patients with moderate or severe migraine headache had elevated PACAP in the external jugular vein during headache (n = 15), that was reduced 1 h after treatment with sumatriptan 6 mg (n = 11), and further reduced interictally (n = 9). The data suggest PACAP, or its receptors, are a promising target for migraine therapeutics.},
  author       = {Zagami, Alessandro S and Edvinsson, Lars and Goadsby, Peter J},
  issn         = {2328-9503},
  language     = {eng},
  number       = {12},
  pages        = {1036--1040},
  publisher    = {Wiley-Blackwell},
  series       = {Annals of Clinical and Translational Neurology},
  title        = {Pituitary adenylate cyclase activating polypeptide and migraine.},
  url          = {http://dx.doi.org/10.1002/acn3.113},
  volume       = {1},
  year         = {2014},
}