Advanced

Analysis of manganese and iron in exhaled endogenous particles

Bredberg, Anna; Ljungkvist, Göran; Taube, Fabian; Ljungström, Evert; Larsson, Per; Mirgorodskaya, Ekaterina; Isaxon, Christina LU ; Gudmundsson, Anders LU ; Forsgard, Niklas and Ohlin, Anna-Carin (2014) In Journal of Analytical Atomic Spectrometry p.730-735
Abstract
Many full-time welders experience some sort of respiratory disorder e.g., asthma, bronchitis and metal fume fever. Thus, welding aerosols are thought to cause airway inflammation. There is a need for markers of welding aerosols in exposure assessments, and as most welding aerosols contain manganese and iron, these metals may possibly be used as an indicator. We have previously developed a novel non-invasive technique to collect endogenous particles in exhaled air (PEx). This study is designed to (i) develop a method for analysis of manganese and iron in PEx and (ii) investigate whether the manganese and/or iron content of PEx changes after exposure to welding aerosols. Methods: nine individuals were experimentally exposed to welding fumes.... (More)
Many full-time welders experience some sort of respiratory disorder e.g., asthma, bronchitis and metal fume fever. Thus, welding aerosols are thought to cause airway inflammation. There is a need for markers of welding aerosols in exposure assessments, and as most welding aerosols contain manganese and iron, these metals may possibly be used as an indicator. We have previously developed a novel non-invasive technique to collect endogenous particles in exhaled air (PEx). This study is designed to (i) develop a method for analysis of manganese and iron in PEx and (ii) investigate whether the manganese and/or iron content of PEx changes after exposure to welding aerosols. Methods: nine individuals were experimentally exposed to welding fumes. PEx was collected at three time points for each individual; before, after and 24 hours after exposure. Analyses of PEx samples were performed using Inductively Coupled Plasma Mass Spectrometry (ICP-MS). Results: four out of nine individuals showed an increase in manganese and iron levels after exposure to welding aerosols. The mean manganese and iron concentration increased from, <LOD to 82–84 pg L−1 (range from 0 to LOD for values <LOD) and 20–86 to 2600 pg L−1 of exhaled air respectively. Conclusions: an ICP-MS method for analysis of manganese and iron in PEx has been developed. The method could easily be expanded to include other trace metals of interest, such as cadmium, nickel or chromium. This first attempt to evaluate PEx as a tool for exposure assessments of airborne metals indicates that the method has potential. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Analytical Atomic Spectrometry
issue
29
pages
730 - 735
publisher
Royal Society of Chemistry
external identifiers
  • scopus:84900672959
ISSN
1364-5544
DOI
10.1039/C3JA50381J
language
English
LU publication?
yes
id
6ed3bef5-f8d4-4104-b4c0-f63771389241 (old id 5051252)
alternative location
http://pubs.rsc.org/en/content/articlehtml/2014/ja/c3ja50381j
date added to LUP
2015-02-24 11:27:42
date last changed
2017-01-01 03:41:41
@article{6ed3bef5-f8d4-4104-b4c0-f63771389241,
  abstract     = {Many full-time welders experience some sort of respiratory disorder e.g., asthma, bronchitis and metal fume fever. Thus, welding aerosols are thought to cause airway inflammation. There is a need for markers of welding aerosols in exposure assessments, and as most welding aerosols contain manganese and iron, these metals may possibly be used as an indicator. We have previously developed a novel non-invasive technique to collect endogenous particles in exhaled air (PEx). This study is designed to (i) develop a method for analysis of manganese and iron in PEx and (ii) investigate whether the manganese and/or iron content of PEx changes after exposure to welding aerosols. Methods: nine individuals were experimentally exposed to welding fumes. PEx was collected at three time points for each individual; before, after and 24 hours after exposure. Analyses of PEx samples were performed using Inductively Coupled Plasma Mass Spectrometry (ICP-MS). Results: four out of nine individuals showed an increase in manganese and iron levels after exposure to welding aerosols. The mean manganese and iron concentration increased from, &lt;LOD to 82–84 pg L−1 (range from 0 to LOD for values &lt;LOD) and 20–86 to 2600 pg L−1 of exhaled air respectively. Conclusions: an ICP-MS method for analysis of manganese and iron in PEx has been developed. The method could easily be expanded to include other trace metals of interest, such as cadmium, nickel or chromium. This first attempt to evaluate PEx as a tool for exposure assessments of airborne metals indicates that the method has potential.},
  author       = {Bredberg, Anna and Ljungkvist, Göran and Taube, Fabian and Ljungström, Evert and Larsson, Per and Mirgorodskaya, Ekaterina and Isaxon, Christina and Gudmundsson, Anders and Forsgard, Niklas and Ohlin, Anna-Carin},
  issn         = {1364-5544},
  language     = {eng},
  number       = {29},
  pages        = {730--735},
  publisher    = {Royal Society of Chemistry},
  series       = {Journal of Analytical Atomic Spectrometry},
  title        = {Analysis of manganese and iron in exhaled endogenous particles},
  url          = {http://dx.doi.org/10.1039/C3JA50381J},
  year         = {2014},
}