Antileishmanial metabolites from Trixis antimenorrhoea
(2014) In Phytochemistry Letters 10. p.281-286- Abstract
- An ethanol extract of the aerial parts of Trixis antimenorrhoea was found to possess activity toward Leishmania brasiliensis. Two new metabolites, the nortrixane 1 and the trixanolide 2, and eleven known were isolated and characterized. The antileishmanial activity against the promastigote form of L. amazonensis and L. brasiliensis was assayed in vitro, and 2 exhibited potent activity with IC50 values below 1 mu g/mL toward both strains. The structures of the isolated compounds were elucidated by NMR spectroscopy and high-resolution mass spectrometry, and the absolute configuration of 2 was determined by using Mosher's ester protocol. (C) 2014 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/5066129
- author
- Maldonado, Eliana LU ; Salamanca, Efrain ; Gimenez, Alberto ; Saavedra, Gloria and Sterner, Olov LU
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Trixis antimenorrhoea, Nortrixane, Trixanolide, Antileishmanial, activity, Structural elucidation
- in
- Phytochemistry Letters
- volume
- 10
- pages
- 281 - 286
- publisher
- Elsevier
- external identifiers
-
- wos:000347915800074
- scopus:84908454836
- ISSN
- 1874-3900
- DOI
- 10.1016/j.phytol.2014.10.017
- language
- English
- LU publication?
- yes
- id
- 380000cb-dd2a-4772-a702-7d96e0b77145 (old id 5066129)
- date added to LUP
- 2016-04-01 09:54:30
- date last changed
- 2022-02-17 04:43:33
@article{380000cb-dd2a-4772-a702-7d96e0b77145, abstract = {{An ethanol extract of the aerial parts of Trixis antimenorrhoea was found to possess activity toward Leishmania brasiliensis. Two new metabolites, the nortrixane 1 and the trixanolide 2, and eleven known were isolated and characterized. The antileishmanial activity against the promastigote form of L. amazonensis and L. brasiliensis was assayed in vitro, and 2 exhibited potent activity with IC50 values below 1 mu g/mL toward both strains. The structures of the isolated compounds were elucidated by NMR spectroscopy and high-resolution mass spectrometry, and the absolute configuration of 2 was determined by using Mosher's ester protocol. (C) 2014 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.}}, author = {{Maldonado, Eliana and Salamanca, Efrain and Gimenez, Alberto and Saavedra, Gloria and Sterner, Olov}}, issn = {{1874-3900}}, keywords = {{Trixis antimenorrhoea; Nortrixane; Trixanolide; Antileishmanial; activity; Structural elucidation}}, language = {{eng}}, pages = {{281--286}}, publisher = {{Elsevier}}, series = {{Phytochemistry Letters}}, title = {{Antileishmanial metabolites from Trixis antimenorrhoea}}, url = {{http://dx.doi.org/10.1016/j.phytol.2014.10.017}}, doi = {{10.1016/j.phytol.2014.10.017}}, volume = {{10}}, year = {{2014}}, }