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Antileishmanial metabolites from Trixis antimenorrhoea

Maldonado, Eliana LU ; Salamanca, Efrain; Gimenez, Alberto; Saavedra, Gloria and Sterner, Olov LU (2014) In Phytochemistry Letters 10. p.281-286
Abstract
An ethanol extract of the aerial parts of Trixis antimenorrhoea was found to possess activity toward Leishmania brasiliensis. Two new metabolites, the nortrixane 1 and the trixanolide 2, and eleven known were isolated and characterized. The antileishmanial activity against the promastigote form of L. amazonensis and L. brasiliensis was assayed in vitro, and 2 exhibited potent activity with IC50 values below 1 mu g/mL toward both strains. The structures of the isolated compounds were elucidated by NMR spectroscopy and high-resolution mass spectrometry, and the absolute configuration of 2 was determined by using Mosher's ester protocol. (C) 2014 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Trixis antimenorrhoea, Nortrixane, Trixanolide, Antileishmanial, activity, Structural elucidation
in
Phytochemistry Letters
volume
10
pages
281 - 286
publisher
Elsevier
external identifiers
  • wos:000347915800074
  • scopus:84908454836
ISSN
1874-3900
DOI
10.1016/j.phytol.2014.10.017
language
English
LU publication?
yes
id
380000cb-dd2a-4772-a702-7d96e0b77145 (old id 5066129)
date added to LUP
2015-02-25 11:07:48
date last changed
2017-03-12 03:01:48
@article{380000cb-dd2a-4772-a702-7d96e0b77145,
  abstract     = {An ethanol extract of the aerial parts of Trixis antimenorrhoea was found to possess activity toward Leishmania brasiliensis. Two new metabolites, the nortrixane 1 and the trixanolide 2, and eleven known were isolated and characterized. The antileishmanial activity against the promastigote form of L. amazonensis and L. brasiliensis was assayed in vitro, and 2 exhibited potent activity with IC50 values below 1 mu g/mL toward both strains. The structures of the isolated compounds were elucidated by NMR spectroscopy and high-resolution mass spectrometry, and the absolute configuration of 2 was determined by using Mosher's ester protocol. (C) 2014 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.},
  author       = {Maldonado, Eliana and Salamanca, Efrain and Gimenez, Alberto and Saavedra, Gloria and Sterner, Olov},
  issn         = {1874-3900},
  keyword      = {Trixis antimenorrhoea,Nortrixane,Trixanolide,Antileishmanial,activity,Structural elucidation},
  language     = {eng},
  pages        = {281--286},
  publisher    = {Elsevier},
  series       = {Phytochemistry Letters},
  title        = {Antileishmanial metabolites from Trixis antimenorrhoea},
  url          = {http://dx.doi.org/10.1016/j.phytol.2014.10.017},
  volume       = {10},
  year         = {2014},
}