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Amperometric In Vitro Monitoring of Penetration through Skin Membrane

Gari, Hala LU ; Rembiesa, Jadwiga; Masilionis, Ignas; Vreva, Naida; Svensson, Birgitta; Sund, Torbjorn; Hansson, Henri; Moren, Anna Karin; Sjöö, Malin LU and Wahlgren, Marie LU , et al. (2015) In Electroanalysis 27(1). p.111-117
Abstract
The aim of this study was to demonstrate that penetration of quercetin, hydrogen peroxide and ascorbic acid through skin membranes can be monitored amperometrically. Skin membrane was fixed on the top of chemically modified electrodes and penetration of the appropriate compound was registered as electrode current. The methodology allows the study of penetration from solution as well as from pharmaceutical creams. From real-time measurements of electrode current, fluxes and diffusion coefficients of mentioned compounds in skin membranes have been estimated.
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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Penetration, Transdermal delivery, Amperometry, Quercetin, Hydrogen, peroxide, Ascorbic acid, Skin membrane
in
Electroanalysis
volume
27
issue
1
pages
111 - 117
publisher
John Wiley & Sons
external identifiers
  • wos:000347838300014
  • scopus:84920983473
ISSN
1040-0397
DOI
10.1002/elan.201400426
language
English
LU publication?
yes
id
f8eee49e-9456-407b-9af9-b09c84ad1dd0 (old id 5069961)
date added to LUP
2015-03-02 07:04:15
date last changed
2017-04-09 03:49:48
@article{f8eee49e-9456-407b-9af9-b09c84ad1dd0,
  abstract     = {The aim of this study was to demonstrate that penetration of quercetin, hydrogen peroxide and ascorbic acid through skin membranes can be monitored amperometrically. Skin membrane was fixed on the top of chemically modified electrodes and penetration of the appropriate compound was registered as electrode current. The methodology allows the study of penetration from solution as well as from pharmaceutical creams. From real-time measurements of electrode current, fluxes and diffusion coefficients of mentioned compounds in skin membranes have been estimated.},
  author       = {Gari, Hala and Rembiesa, Jadwiga and Masilionis, Ignas and Vreva, Naida and Svensson, Birgitta and Sund, Torbjorn and Hansson, Henri and Moren, Anna Karin and Sjöö, Malin and Wahlgren, Marie and Engblom, Johan and Ruzgas, Tautgirdas},
  issn         = {1040-0397},
  keyword      = {Penetration,Transdermal delivery,Amperometry,Quercetin,Hydrogen,peroxide,Ascorbic acid,Skin membrane},
  language     = {eng},
  number       = {1},
  pages        = {111--117},
  publisher    = {John Wiley & Sons},
  series       = {Electroanalysis},
  title        = {Amperometric In Vitro Monitoring of Penetration through Skin Membrane},
  url          = {http://dx.doi.org/10.1002/elan.201400426},
  volume       = {27},
  year         = {2015},
}