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The length and number of sedentary bouts predict fibrinogen levels in postmenopausal women

Izzicupo, Pascal ; Di Blasio, Andrea ; Di Credico, Andrea ; Gaggi, Giulia ; Vamvakis, Anastasios ; Napolitano, Giorgio ; Ricci, Fabrizio LU ; Gallina, Sabina ; Ghinassi, Barbara and Di Baldassarre, Angela (2020) In International Journal of Environmental Research and Public Health 17(9).
Abstract

Menopause is associated with adverse changes in coagulation homeostasis. We aimed to investigate the association between objectively measured sedentary behavior (SB) and SB bouts (i.e., number and length of SB bouts) vs. fibrinogen levels in post-menopausal women. Fifty-three post-menopausal women (age 59.8 ± 6.2 years, BMI 27.3 ± 4.4) wore a multisensory device (Sensewear Mini Armband, BodyMedia, Inc., Pittsburgh, PA) for 5 days, to measure SB and physical activity (PA). Blood samples were collected to measure serum fibrinogen. Fibrinogen was directly correlated with SB (r = −0.48, p < 0.01), lying down during awake time (r = −0.50, p < 0.01), and both medium (11–30 mins) and very long bouts (>1 h) of SB (r = −0.59, p <... (More)

Menopause is associated with adverse changes in coagulation homeostasis. We aimed to investigate the association between objectively measured sedentary behavior (SB) and SB bouts (i.e., number and length of SB bouts) vs. fibrinogen levels in post-menopausal women. Fifty-three post-menopausal women (age 59.8 ± 6.2 years, BMI 27.3 ± 4.4) wore a multisensory device (Sensewear Mini Armband, BodyMedia, Inc., Pittsburgh, PA) for 5 days, to measure SB and physical activity (PA). Blood samples were collected to measure serum fibrinogen. Fibrinogen was directly correlated with SB (r = −0.48, p < 0.01), lying down during awake time (r = −0.50, p < 0.01), and both medium (11–30 mins) and very long bouts (>1 h) of SB (r = −0.59, p < 0.01; r = −0.51, p < 0.01, respectively), and inversely correlated with moderate to vigorous-intensity physical activity (r = −0.39, p < 0.01). Furthermore, fibrinogen was also directly correlated with BMI (r = −0.28, p < 0.05). In postmenopausal women without prevalent cardiovascular disease, the number of prolonged and uninterrupted sedentary bouts is directly correlated with increased fibrinogen levels, regardless of PA and BMI. This result suggests the importance of delivering new strategies to counteract the increase of sedentariness and inactivity of the postmenopausal population.

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author
; ; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Cardiovascular disease risk, Hemostasis, Menopause, Physical activity, Sedentary behavior, Women’s health
in
International Journal of Environmental Research and Public Health
volume
17
issue
9
article number
3051
publisher
MDPI AG
external identifiers
  • pmid:32353951
  • scopus:85084816947
ISSN
1661-7827
DOI
10.3390/ijerph17093051
language
English
LU publication?
yes
id
50724043-3ec2-4bed-bcea-d58c9f68608e
date added to LUP
2020-06-17 10:31:04
date last changed
2024-06-26 17:06:11
@article{50724043-3ec2-4bed-bcea-d58c9f68608e,
  abstract     = {{<p>Menopause is associated with adverse changes in coagulation homeostasis. We aimed to investigate the association between objectively measured sedentary behavior (SB) and SB bouts (i.e., number and length of SB bouts) vs. fibrinogen levels in post-menopausal women. Fifty-three post-menopausal women (age 59.8 ± 6.2 years, BMI 27.3 ± 4.4) wore a multisensory device (Sensewear Mini Armband, BodyMedia, Inc., Pittsburgh, PA) for 5 days, to measure SB and physical activity (PA). Blood samples were collected to measure serum fibrinogen. Fibrinogen was directly correlated with SB (r = −0.48, p &lt; 0.01), lying down during awake time (r = −0.50, p &lt; 0.01), and both medium (11–30 mins) and very long bouts (&gt;1 h) of SB (r = −0.59, p &lt; 0.01; r = −0.51, p &lt; 0.01, respectively), and inversely correlated with moderate to vigorous-intensity physical activity (r = −0.39, p &lt; 0.01). Furthermore, fibrinogen was also directly correlated with BMI (r = −0.28, p &lt; 0.05). In postmenopausal women without prevalent cardiovascular disease, the number of prolonged and uninterrupted sedentary bouts is directly correlated with increased fibrinogen levels, regardless of PA and BMI. This result suggests the importance of delivering new strategies to counteract the increase of sedentariness and inactivity of the postmenopausal population.</p>}},
  author       = {{Izzicupo, Pascal and Di Blasio, Andrea and Di Credico, Andrea and Gaggi, Giulia and Vamvakis, Anastasios and Napolitano, Giorgio and Ricci, Fabrizio and Gallina, Sabina and Ghinassi, Barbara and Di Baldassarre, Angela}},
  issn         = {{1661-7827}},
  keywords     = {{Cardiovascular disease risk; Hemostasis; Menopause; Physical activity; Sedentary behavior; Women’s health}},
  language     = {{eng}},
  month        = {{04}},
  number       = {{9}},
  publisher    = {{MDPI AG}},
  series       = {{International Journal of Environmental Research and Public Health}},
  title        = {{The length and number of sedentary bouts predict fibrinogen levels in postmenopausal women}},
  url          = {{http://dx.doi.org/10.3390/ijerph17093051}},
  doi          = {{10.3390/ijerph17093051}},
  volume       = {{17}},
  year         = {{2020}},
}