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Plasma 25-Hydroxyvitamin D concentration and risk of islet autoimmunity

Norris, Jill M.; Lee, Hye Seung; Frederiksen, Brittni; Erlund, Iris; Uusitalo, Ulla; Yang, Jimin; Lernmark, Åke LU ; Simell, Olli; Toppari, Jorma and Rewers, Marian, et al. (2018) In Diabetes 67(1). p.146-154
Abstract

We examined the association between plasma 25- hydroxyvitamin D [25(OH)D] concentration and islet autoimmunity (IA) and whether vitamin D gene polymorphisms modify the effect of 25(OH)D on IA risk. We followed 8,676 children at increased genetic risk of type 1 diabetes at six sites in the U.S. and Europe. We defined IA as positivity for at least one autoantibody (GADA, IAA, or IA-2A) on two or more visits. We conducted a risk set sampled nested casecontrol study of 376 IA case subjects and up to 3 control subjects per case subject. 25(OH)D concentrationwas measured on all samples prior to, and including, the first IA positive visit. Nine polymorphisms in VDR, CYP24A, CYP27B1, GC, and RXRA were analyzed as effect modifiers of 25(OH)D.... (More)

We examined the association between plasma 25- hydroxyvitamin D [25(OH)D] concentration and islet autoimmunity (IA) and whether vitamin D gene polymorphisms modify the effect of 25(OH)D on IA risk. We followed 8,676 children at increased genetic risk of type 1 diabetes at six sites in the U.S. and Europe. We defined IA as positivity for at least one autoantibody (GADA, IAA, or IA-2A) on two or more visits. We conducted a risk set sampled nested casecontrol study of 376 IA case subjects and up to 3 control subjects per case subject. 25(OH)D concentrationwas measured on all samples prior to, and including, the first IA positive visit. Nine polymorphisms in VDR, CYP24A, CYP27B1, GC, and RXRA were analyzed as effect modifiers of 25(OH)D. Adjusting for HLA-DR-DQ and ancestry, higher childhood 25(OH)D was associated with lower IA risk (odds ratio = 0.93 for a 5 nmol/L difference; 95% CI 0.89, 0.97). Moreover, this association was modified by VDR rs7975232 (interaction P = 0.0072), where increased childhood 25(OH)D was associated with a decreasing IA risk based upon number of minor alleles: 0 (1.00; 0.93, 1.07), 1 (0.92; 0.89, 0.96), and 2 (0.86; 0.80, 0.92). Vitamin D and VDR may have a combined role in IA development in children at increased genetic risk for type 1 diabetes.

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published
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Diabetes
volume
67
issue
1
pages
9 pages
publisher
American Diabetes Association Inc.
external identifiers
  • scopus:85038957886
ISSN
0012-1797
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English
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yes
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5072688e-1ac3-46c5-b317-326f8c2bd1b6
date added to LUP
2018-01-22 11:10:30
date last changed
2018-05-29 09:44:40
@article{5072688e-1ac3-46c5-b317-326f8c2bd1b6,
  abstract     = {<p>We examined the association between plasma 25- hydroxyvitamin D [25(OH)D] concentration and islet autoimmunity (IA) and whether vitamin D gene polymorphisms modify the effect of 25(OH)D on IA risk. We followed 8,676 children at increased genetic risk of type 1 diabetes at six sites in the U.S. and Europe. We defined IA as positivity for at least one autoantibody (GADA, IAA, or IA-2A) on two or more visits. We conducted a risk set sampled nested casecontrol study of 376 IA case subjects and up to 3 control subjects per case subject. 25(OH)D concentrationwas measured on all samples prior to, and including, the first IA positive visit. Nine polymorphisms in VDR, CYP24A, CYP27B1, GC, and RXRA were analyzed as effect modifiers of 25(OH)D. Adjusting for HLA-DR-DQ and ancestry, higher childhood 25(OH)D was associated with lower IA risk (odds ratio = 0.93 for a 5 nmol/L difference; 95% CI 0.89, 0.97). Moreover, this association was modified by VDR rs7975232 (interaction P = 0.0072), where increased childhood 25(OH)D was associated with a decreasing IA risk based upon number of minor alleles: 0 (1.00; 0.93, 1.07), 1 (0.92; 0.89, 0.96), and 2 (0.86; 0.80, 0.92). Vitamin D and VDR may have a combined role in IA development in children at increased genetic risk for type 1 diabetes.</p>},
  author       = {Norris, Jill M. and Lee, Hye Seung and Frederiksen, Brittni and Erlund, Iris and Uusitalo, Ulla and Yang, Jimin and Lernmark, Åke and Simell, Olli and Toppari, Jorma and Rewers, Marian and Ziegler, Anette G. and She, Jin Xiong and Onengut-Gumuscu, Suna and Chen, Wei Min and Rich, Stephen S. and Sundvall, Jouko and Akolkar, Beena and Krischer, Jeffrey and Virtanen, Suvi M. and Hagopian, William},
  issn         = {0012-1797},
  language     = {eng},
  number       = {1},
  pages        = {146--154},
  publisher    = {American Diabetes Association Inc.},
  series       = {Diabetes},
  title        = {Plasma 25-Hydroxyvitamin D concentration and risk of islet autoimmunity},
  url          = {http://dx.doi.org/},
  volume       = {67},
  year         = {2018},
}