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Electrocardiographic Findings in Systemic Lupus Erythematosus: Data From an International Inception Cohort

Bourre-Tessier, Josiane; Urowitz, Murray B.; Clarke, Ann E.; Bernatsky, Sasha; Krantz, Mori J.; Huynh, Thao; Joseph, Lawrence; Belisle, Patrick; Bae, Sang-Cheol and Hanly, John G., et al. (2015) In Arthritis Care and Research1988-01-01+01:002000-01-01+01:00 67(1). p.128-135
Abstract
Objective. To estimate the early prevalence of various electrocardiographic (EKG) abnormalities in patients with systemic lupus erythematosus (SLE) and to evaluate possible associations between repolarization changes (increased corrected QT [QTc] and QT dispersion [QTd]) and clinical and laboratory variables, including the anti-Ro/SSA level and specificity (52 or 60 kd). Methods. We studied adult SLE patients from 19 centers participating in the Systemic Lupus International Collaborating Clinics (SLICC) Inception Registry. Demographics, disease activity (Systemic Lupus Erythematosus Disease Activity Index 2000 [SLEDAI-2K]), disease damage (SLICC/American College of Rheumatology Damage Index [SDI]), and laboratory data from the baseline or... (More)
Objective. To estimate the early prevalence of various electrocardiographic (EKG) abnormalities in patients with systemic lupus erythematosus (SLE) and to evaluate possible associations between repolarization changes (increased corrected QT [QTc] and QT dispersion [QTd]) and clinical and laboratory variables, including the anti-Ro/SSA level and specificity (52 or 60 kd). Methods. We studied adult SLE patients from 19 centers participating in the Systemic Lupus International Collaborating Clinics (SLICC) Inception Registry. Demographics, disease activity (Systemic Lupus Erythematosus Disease Activity Index 2000 [SLEDAI-2K]), disease damage (SLICC/American College of Rheumatology Damage Index [SDI]), and laboratory data from the baseline or first followup visit were assessed. Multivariate logistic and linear regression models were used to asses for any cross-sectional associations between anti-Ro/SSA and EKG repolarization abnormalities. Results. For the 779 patients included, mean +/- SD age was 35.2 +/- 13.8 years, 88.4% were women, and mean +/- SD disease duration was 10.5 +/- 14.5 months. Mean +/- SD SLEDAI-2K score was 5.4 +/- 5.6 and mean +/- SD SDI score was 0.5 +/- 1.0. EKG abnormalities were frequent and included nonspecific ST-T changes (30.9%), possible left ventricular hypertrophy (5.4%), and supraventricular arrhythmias (1.3%). A QTc >= 440 msec was found in 15.3%, while a QTc >= 460 msec was found in 5.3%. Mean +/- SD QTd was 34.2 +/- 14.7 msec and QTd >= 40 msec was frequent (38.1%). Neither the specificity nor the level of anti-Ro/SSA was associated with QTc duration or QTd, although confidence intervals were wide. Total SDI was significantly associated with a QTc interval exceeding 440 msec (odds ratio 1.38 [95% confidence interval 1.06, 1.79]). Conclusion. A substantial proportion of patients with recent-onset SLE exhibited repolarization abnormalities, although severe abnormalities were rare. (Less)
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Contribution to journal
publication status
published
subject
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Arthritis Care and Research1988-01-01+01:002000-01-01+01:00
volume
67
issue
1
pages
128 - 135
publisher
John Wiley & Sons
external identifiers
  • wos:000346917200018
  • scopus:84919966097
ISSN
2151-4658
DOI
10.1002/acr.22370
language
English
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yes
id
16fd1320-0e52-49c6-ac5b-c79cd5f1a6ab (old id 5085067)
date added to LUP
2015-03-02 07:11:06
date last changed
2017-10-22 03:22:33
@article{16fd1320-0e52-49c6-ac5b-c79cd5f1a6ab,
  abstract     = {Objective. To estimate the early prevalence of various electrocardiographic (EKG) abnormalities in patients with systemic lupus erythematosus (SLE) and to evaluate possible associations between repolarization changes (increased corrected QT [QTc] and QT dispersion [QTd]) and clinical and laboratory variables, including the anti-Ro/SSA level and specificity (52 or 60 kd). Methods. We studied adult SLE patients from 19 centers participating in the Systemic Lupus International Collaborating Clinics (SLICC) Inception Registry. Demographics, disease activity (Systemic Lupus Erythematosus Disease Activity Index 2000 [SLEDAI-2K]), disease damage (SLICC/American College of Rheumatology Damage Index [SDI]), and laboratory data from the baseline or first followup visit were assessed. Multivariate logistic and linear regression models were used to asses for any cross-sectional associations between anti-Ro/SSA and EKG repolarization abnormalities. Results. For the 779 patients included, mean +/- SD age was 35.2 +/- 13.8 years, 88.4% were women, and mean +/- SD disease duration was 10.5 +/- 14.5 months. Mean +/- SD SLEDAI-2K score was 5.4 +/- 5.6 and mean +/- SD SDI score was 0.5 +/- 1.0. EKG abnormalities were frequent and included nonspecific ST-T changes (30.9%), possible left ventricular hypertrophy (5.4%), and supraventricular arrhythmias (1.3%). A QTc >= 440 msec was found in 15.3%, while a QTc >= 460 msec was found in 5.3%. Mean +/- SD QTd was 34.2 +/- 14.7 msec and QTd >= 40 msec was frequent (38.1%). Neither the specificity nor the level of anti-Ro/SSA was associated with QTc duration or QTd, although confidence intervals were wide. Total SDI was significantly associated with a QTc interval exceeding 440 msec (odds ratio 1.38 [95% confidence interval 1.06, 1.79]). Conclusion. A substantial proportion of patients with recent-onset SLE exhibited repolarization abnormalities, although severe abnormalities were rare.},
  author       = {Bourre-Tessier, Josiane and Urowitz, Murray B. and Clarke, Ann E. and Bernatsky, Sasha and Krantz, Mori J. and Huynh, Thao and Joseph, Lawrence and Belisle, Patrick and Bae, Sang-Cheol and Hanly, John G. and Wallace, Daniel J. and Gordon, Caroline and Isenberg, David and Rahman, Anisur and Gladman, Dafna D. and Fortin, Paul R. and Merrill, Joan T. and Romero-Diaz, Juanita and Sanchez-Guerrero, Jorge and Fessler, Barri and Alarcon, Graciela S. and Steinsson, Kristjan and Bruce, Ian N. and Ginzler, Ellen and Dooley, Mary Anne and Nived, Ola and Sturfelt, Gunnar and Kalunian, Kenneth and Ramos-Casals, Manuel and Petri, Michelle and Zoma, Asad and Pineau, Christian A.},
  issn         = {2151-4658},
  language     = {eng},
  number       = {1},
  pages        = {128--135},
  publisher    = {John Wiley & Sons},
  series       = {Arthritis Care and Research1988-01-01+01:002000-01-01+01:00},
  title        = {Electrocardiographic Findings in Systemic Lupus Erythematosus: Data From an International Inception Cohort},
  url          = {http://dx.doi.org/10.1002/acr.22370},
  volume       = {67},
  year         = {2015},
}