Electrocardiographic Findings in Systemic Lupus Erythematosus: Data From an International Inception Cohort
(2015) In Arthritis Care and Research 67(1). p.128-135- Abstract
- Objective. To estimate the early prevalence of various electrocardiographic (EKG) abnormalities in patients with systemic lupus erythematosus (SLE) and to evaluate possible associations between repolarization changes (increased corrected QT [QTc] and QT dispersion [QTd]) and clinical and laboratory variables, including the anti-Ro/SSA level and specificity (52 or 60 kd). Methods. We studied adult SLE patients from 19 centers participating in the Systemic Lupus International Collaborating Clinics (SLICC) Inception Registry. Demographics, disease activity (Systemic Lupus Erythematosus Disease Activity Index 2000 [SLEDAI-2K]), disease damage (SLICC/American College of Rheumatology Damage Index [SDI]), and laboratory data from the baseline or... (More)
- Objective. To estimate the early prevalence of various electrocardiographic (EKG) abnormalities in patients with systemic lupus erythematosus (SLE) and to evaluate possible associations between repolarization changes (increased corrected QT [QTc] and QT dispersion [QTd]) and clinical and laboratory variables, including the anti-Ro/SSA level and specificity (52 or 60 kd). Methods. We studied adult SLE patients from 19 centers participating in the Systemic Lupus International Collaborating Clinics (SLICC) Inception Registry. Demographics, disease activity (Systemic Lupus Erythematosus Disease Activity Index 2000 [SLEDAI-2K]), disease damage (SLICC/American College of Rheumatology Damage Index [SDI]), and laboratory data from the baseline or first followup visit were assessed. Multivariate logistic and linear regression models were used to asses for any cross-sectional associations between anti-Ro/SSA and EKG repolarization abnormalities. Results. For the 779 patients included, mean +/- SD age was 35.2 +/- 13.8 years, 88.4% were women, and mean +/- SD disease duration was 10.5 +/- 14.5 months. Mean +/- SD SLEDAI-2K score was 5.4 +/- 5.6 and mean +/- SD SDI score was 0.5 +/- 1.0. EKG abnormalities were frequent and included nonspecific ST-T changes (30.9%), possible left ventricular hypertrophy (5.4%), and supraventricular arrhythmias (1.3%). A QTc >= 440 msec was found in 15.3%, while a QTc >= 460 msec was found in 5.3%. Mean +/- SD QTd was 34.2 +/- 14.7 msec and QTd >= 40 msec was frequent (38.1%). Neither the specificity nor the level of anti-Ro/SSA was associated with QTc duration or QTd, although confidence intervals were wide. Total SDI was significantly associated with a QTc interval exceeding 440 msec (odds ratio 1.38 [95% confidence interval 1.06, 1.79]). Conclusion. A substantial proportion of patients with recent-onset SLE exhibited repolarization abnormalities, although severe abnormalities were rare. (Less)
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https://lup.lub.lu.se/record/5085067
- author
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Arthritis Care and Research
- volume
- 67
- issue
- 1
- pages
- 128 - 135
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- wos:000346917200018
- scopus:84919966097
- pmid:24838943
- ISSN
- 2151-4658
- DOI
- 10.1002/acr.22370
- language
- English
- LU publication?
- yes
- id
- 16fd1320-0e52-49c6-ac5b-c79cd5f1a6ab (old id 5085067)
- date added to LUP
- 2016-04-01 10:46:18
- date last changed
- 2022-03-04 22:40:21
@article{16fd1320-0e52-49c6-ac5b-c79cd5f1a6ab,
abstract = {{Objective. To estimate the early prevalence of various electrocardiographic (EKG) abnormalities in patients with systemic lupus erythematosus (SLE) and to evaluate possible associations between repolarization changes (increased corrected QT [QTc] and QT dispersion [QTd]) and clinical and laboratory variables, including the anti-Ro/SSA level and specificity (52 or 60 kd). Methods. We studied adult SLE patients from 19 centers participating in the Systemic Lupus International Collaborating Clinics (SLICC) Inception Registry. Demographics, disease activity (Systemic Lupus Erythematosus Disease Activity Index 2000 [SLEDAI-2K]), disease damage (SLICC/American College of Rheumatology Damage Index [SDI]), and laboratory data from the baseline or first followup visit were assessed. Multivariate logistic and linear regression models were used to asses for any cross-sectional associations between anti-Ro/SSA and EKG repolarization abnormalities. Results. For the 779 patients included, mean +/- SD age was 35.2 +/- 13.8 years, 88.4% were women, and mean +/- SD disease duration was 10.5 +/- 14.5 months. Mean +/- SD SLEDAI-2K score was 5.4 +/- 5.6 and mean +/- SD SDI score was 0.5 +/- 1.0. EKG abnormalities were frequent and included nonspecific ST-T changes (30.9%), possible left ventricular hypertrophy (5.4%), and supraventricular arrhythmias (1.3%). A QTc >= 440 msec was found in 15.3%, while a QTc >= 460 msec was found in 5.3%. Mean +/- SD QTd was 34.2 +/- 14.7 msec and QTd >= 40 msec was frequent (38.1%). Neither the specificity nor the level of anti-Ro/SSA was associated with QTc duration or QTd, although confidence intervals were wide. Total SDI was significantly associated with a QTc interval exceeding 440 msec (odds ratio 1.38 [95% confidence interval 1.06, 1.79]). Conclusion. A substantial proportion of patients with recent-onset SLE exhibited repolarization abnormalities, although severe abnormalities were rare.}},
author = {{Bourre-Tessier, Josiane and Urowitz, Murray B. and Clarke, Ann E. and Bernatsky, Sasha and Krantz, Mori J. and Huynh, Thao and Joseph, Lawrence and Belisle, Patrick and Bae, Sang-Cheol and Hanly, John G. and Wallace, Daniel J. and Gordon, Caroline and Isenberg, David and Rahman, Anisur and Gladman, Dafna D. and Fortin, Paul R. and Merrill, Joan T. and Romero-Diaz, Juanita and Sanchez-Guerrero, Jorge and Fessler, Barri and Alarcon, Graciela S. and Steinsson, Kristjan and Bruce, Ian N. and Ginzler, Ellen and Dooley, Mary Anne and Nived, Ola and Sturfelt, Gunnar and Kalunian, Kenneth and Ramos-Casals, Manuel and Petri, Michelle and Zoma, Asad and Pineau, Christian A.}},
issn = {{2151-4658}},
language = {{eng}},
number = {{1}},
pages = {{128--135}},
publisher = {{John Wiley & Sons Inc.}},
series = {{Arthritis Care and Research}},
title = {{Electrocardiographic Findings in Systemic Lupus Erythematosus: Data From an International Inception Cohort}},
url = {{http://dx.doi.org/10.1002/acr.22370}},
doi = {{10.1002/acr.22370}},
volume = {{67}},
year = {{2015}},
}