Fifteen-year risk of major coronary events predicted by Holter ST-monitoring in asymptomatic middle-aged men.
(2005) In European Journal of Cardiovascular Prevention & Rehabilitation 12(5). p.478-483- Abstract
- Background: Ambulatory electrocardiogram monitoring (Holter) with ST-analysis as a measure of myocardial ichemia has in populations with coronary heart disease been shown to predict major coronary events: death, myocardial infarction or coronary revascularization. There has, however, been conflicting evidence regarding the usefulness of this technique in identification of healthy subjects with increased risk for coronary heart disease. The aim of this study was to assess if Holter monitoring with ST-analysis could be used to predict future major coronary events in asymptomatic middle-aged men with a defined aggregation of traditional risk factors for coronary heart disease.
Methods: One hundred and fifty-five... (More) - Background: Ambulatory electrocardiogram monitoring (Holter) with ST-analysis as a measure of myocardial ichemia has in populations with coronary heart disease been shown to predict major coronary events: death, myocardial infarction or coronary revascularization. There has, however, been conflicting evidence regarding the usefulness of this technique in identification of healthy subjects with increased risk for coronary heart disease. The aim of this study was to assess if Holter monitoring with ST-analysis could be used to predict future major coronary events in asymptomatic middle-aged men with a defined aggregation of traditional risk factors for coronary heart disease.
Methods: One hundred and fifty-five asymptomatic participants from the city of Malmo, Sweden, with known levels of conventional cardiovascular risk factors underwent Holter monitoring for analysis of transient ST-segment depression at the age of 55 years. Fifteen years after the Holter monitoring, hospital records, diagnosis and death registries were revisited for major coronary events.
Results: An ST-segment depression of 1 mm or greater (0.1 mV) was considered significant for myocardial ischemia and was found in 54 of the 155 men. There were no significant differences in risk factors in the two groups at baseline. The 15-year incidence of a first major coronary event was significantly higher in men with ST-segment depression (39%) than in men without ST-segment depression (20%) (P<0.015). A Holter electrocardiogram could predict future major coronary events with a positive and negative predictive value of 35 and 80%, respectively.
Conclusions: Holter monitoring can be used as a complement to conventional risk factor evaluation in deciding whether or not to treat risk factors for CHD in asymptomatic subjects. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/144776
- author
- Stagmo, Martin LU ; Juul-Möller, Steen LU and Israelsson, Bo LU
- organization
- publishing date
- 2005
- type
- Contribution to journal
- publication status
- published
- subject
- in
- European Journal of Cardiovascular Prevention & Rehabilitation
- volume
- 12
- issue
- 5
- pages
- 478 - 483
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- wos:000249264700010
- scopus:33644875583
- ISSN
- 1741-8275
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Emergency medicine/Medicine/Surgery (013240200), Cardiology Research Group (013242120)
- id
- 5086dde7-be1b-49e1-8065-78531f3177c7 (old id 144776)
- alternative location
- http://www.ejcpr.com/pt/re/ejcpr/abstract.00149831-200510000-00010.htm;jsessionid=GtrJ7RHCXg3g0jnZDC2g8KQvQ69Q1Xbv5gKvdpH8NvqwTdyv1xcJ!1683421839!181195628!8091!-1
- date added to LUP
- 2016-04-01 12:23:24
- date last changed
- 2022-04-21 06:48:46
@article{5086dde7-be1b-49e1-8065-78531f3177c7, abstract = {{Background: Ambulatory electrocardiogram monitoring (Holter) with ST-analysis as a measure of myocardial ichemia has in populations with coronary heart disease been shown to predict major coronary events: death, myocardial infarction or coronary revascularization. There has, however, been conflicting evidence regarding the usefulness of this technique in identification of healthy subjects with increased risk for coronary heart disease. The aim of this study was to assess if Holter monitoring with ST-analysis could be used to predict future major coronary events in asymptomatic middle-aged men with a defined aggregation of traditional risk factors for coronary heart disease.<br/><br> <br/><br> Methods: One hundred and fifty-five asymptomatic participants from the city of Malmo, Sweden, with known levels of conventional cardiovascular risk factors underwent Holter monitoring for analysis of transient ST-segment depression at the age of 55 years. Fifteen years after the Holter monitoring, hospital records, diagnosis and death registries were revisited for major coronary events.<br/><br> <br/><br> Results: An ST-segment depression of 1 mm or greater (0.1 mV) was considered significant for myocardial ischemia and was found in 54 of the 155 men. There were no significant differences in risk factors in the two groups at baseline. The 15-year incidence of a first major coronary event was significantly higher in men with ST-segment depression (39%) than in men without ST-segment depression (20%) (P<0.015). A Holter electrocardiogram could predict future major coronary events with a positive and negative predictive value of 35 and 80%, respectively.<br/><br> <br/><br> Conclusions: Holter monitoring can be used as a complement to conventional risk factor evaluation in deciding whether or not to treat risk factors for CHD in asymptomatic subjects.}}, author = {{Stagmo, Martin and Juul-Möller, Steen and Israelsson, Bo}}, issn = {{1741-8275}}, language = {{eng}}, number = {{5}}, pages = {{478--483}}, publisher = {{Lippincott Williams & Wilkins}}, series = {{European Journal of Cardiovascular Prevention & Rehabilitation}}, title = {{Fifteen-year risk of major coronary events predicted by Holter ST-monitoring in asymptomatic middle-aged men.}}, url = {{http://www.ejcpr.com/pt/re/ejcpr/abstract.00149831-200510000-00010.htm;jsessionid=GtrJ7RHCXg3g0jnZDC2g8KQvQ69Q1Xbv5gKvdpH8NvqwTdyv1xcJ!1683421839!181195628!8091!-1}}, volume = {{12}}, year = {{2005}}, }