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Nickel penetration into stratum corneum in FLG null carriers—A human experimental study

Julander, Anneli ; Liljedahl, Emelie Rietz LU ; Korres de Paula, Helena LU ; Assarsson, Eva LU ; Engfeldt, Malin LU ; Littorin, Margareta LU ; Shobana Anto, Christine ; Lidén, Carola and Broberg, Karin LU orcid (2022) In Contact Dermatitis 87(2). p.154-161
Abstract

Background: The filaggrin gene (FLG) plays a role in skin diseases, with the skin barrier function being impaired in FLG null carriers. The role of FLG status in relation to nickel penetration into the skin remains unclear. Objectives: To elucidate the association between FLG status and nickel penetration into stratum corneum (SC) in individuals without self-reported history of nickel allergy. Methods: Forty participants (23 FLG wt and 17 FLG null) were exposed to a nickel solution (80 μg/cm2) which was applied onto 2 × 2 cm on their left forearm. After 4 h, the area was tape-stripped with 10 consecutive tapes. Nickel in each tape was quantified using inductively coupled plasma mass spectrometry. Results: The average... (More)

Background: The filaggrin gene (FLG) plays a role in skin diseases, with the skin barrier function being impaired in FLG null carriers. The role of FLG status in relation to nickel penetration into the skin remains unclear. Objectives: To elucidate the association between FLG status and nickel penetration into stratum corneum (SC) in individuals without self-reported history of nickel allergy. Methods: Forty participants (23 FLG wt and 17 FLG null) were exposed to a nickel solution (80 μg/cm2) which was applied onto 2 × 2 cm on their left forearm. After 4 h, the area was tape-stripped with 10 consecutive tapes. Nickel in each tape was quantified using inductively coupled plasma mass spectrometry. Results: The average recovered nickel dose was 35%–48%. A tendency towards lower recovery was seen in FLG null carriers compared to FLG wt carriers, and lower recovery in those with history of skin and/or respiratory symptoms compared to those without such history. This was however not statistically significant. Conclusion: FLG null carriers had less nickel recovered by tape strips compared with FLG wt carriers and, compared with individuals without a history of skin and/or respiratory symptoms, indicating higher nickel penetration into SC for FLG null carriers, but further studies are needed.

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author
; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
dermal exposure, FLG status, genetic susceptibility, human exposure study, nickel penetration, respiratory symptoms, skin symptoms
in
Contact Dermatitis
volume
87
issue
2
pages
8 pages
publisher
Wiley-Blackwell
external identifiers
  • scopus:85129425966
  • pmid:35474514
ISSN
0105-1873
DOI
10.1111/cod.14137
language
English
LU publication?
yes
id
50aaf857-1f50-4259-8aba-939c4181ca0b
date added to LUP
2022-08-15 11:14:49
date last changed
2024-04-18 13:05:53
@article{50aaf857-1f50-4259-8aba-939c4181ca0b,
  abstract     = {{<p>Background: The filaggrin gene (FLG) plays a role in skin diseases, with the skin barrier function being impaired in FLG null carriers. The role of FLG status in relation to nickel penetration into the skin remains unclear. Objectives: To elucidate the association between FLG status and nickel penetration into stratum corneum (SC) in individuals without self-reported history of nickel allergy. Methods: Forty participants (23 FLG wt and 17 FLG null) were exposed to a nickel solution (80 μg/cm<sup>2</sup>) which was applied onto 2 × 2 cm on their left forearm. After 4 h, the area was tape-stripped with 10 consecutive tapes. Nickel in each tape was quantified using inductively coupled plasma mass spectrometry. Results: The average recovered nickel dose was 35%–48%. A tendency towards lower recovery was seen in FLG null carriers compared to FLG wt carriers, and lower recovery in those with history of skin and/or respiratory symptoms compared to those without such history. This was however not statistically significant. Conclusion: FLG null carriers had less nickel recovered by tape strips compared with FLG wt carriers and, compared with individuals without a history of skin and/or respiratory symptoms, indicating higher nickel penetration into SC for FLG null carriers, but further studies are needed.</p>}},
  author       = {{Julander, Anneli and Liljedahl, Emelie Rietz and Korres de Paula, Helena and Assarsson, Eva and Engfeldt, Malin and Littorin, Margareta and Shobana Anto, Christine and Lidén, Carola and Broberg, Karin}},
  issn         = {{0105-1873}},
  keywords     = {{dermal exposure; FLG status; genetic susceptibility; human exposure study; nickel penetration; respiratory symptoms; skin symptoms}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{154--161}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Contact Dermatitis}},
  title        = {{Nickel penetration into stratum corneum in FLG null carriers—A human experimental study}},
  url          = {{http://dx.doi.org/10.1111/cod.14137}},
  doi          = {{10.1111/cod.14137}},
  volume       = {{87}},
  year         = {{2022}},
}